ID ABCA8_DICDI Reviewed; 837 AA.
AC Q55BC0; Q8T6I9;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 27-MAR-2024, entry version 116.
DE RecName: Full=ABC transporter A family member 8;
DE AltName: Full=ABC transporter ABCA.8;
GN Name=abcA8; ORFNames=DDB_G0271138;
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND NOMENCLATURE.
RC STRAIN=AX4;
RX PubMed=12456012; DOI=10.1128/ec.1.4.643-652.2002;
RA Anjard C., Loomis W.F.;
RT "Evolutionary analyses of ABC transporters of Dictyostelium discoideum.";
RL Eukaryot. Cell 1:643-652(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCA family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL85301.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AF465310; AAL85301.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AAFI02000006; EAL71699.1; -; Genomic_DNA.
DR RefSeq; XP_645692.1; XM_640600.1.
DR AlphaFoldDB; Q55BC0; -.
DR SMR; Q55BC0; -.
DR STRING; 44689.Q55BC0; -.
DR PaxDb; 44689-DDB0216250; -.
DR EnsemblProtists; EAL71699; EAL71699; DDB_G0271138.
DR GeneID; 8617885; -.
DR KEGG; ddi:DDB_G0271138; -.
DR dictyBase; DDB_G0271138; abcA8.
DR eggNOG; KOG0059; Eukaryota.
DR HOGENOM; CLU_000604_19_5_1; -.
DR InParanoid; Q55BC0; -.
DR OMA; TWENLND; -.
DR PhylomeDB; Q55BC0; -.
DR Reactome; R-DDI-1369062; ABC transporters in lipid homeostasis.
DR Reactome; R-DDI-2453902; The canonical retinoid cycle in rods (twilight vision).
DR Reactome; R-DDI-382556; ABC-family proteins mediated transport.
DR Reactome; R-DDI-5683826; Surfactant metabolism.
DR Reactome; R-DDI-6798695; Neutrophil degranulation.
DR Reactome; R-DDI-8963896; HDL assembly.
DR PRO; PR:Q55BC0; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005319; F:lipid transporter activity; IBA:GO_Central.
DR GO; GO:0006869; P:lipid transport; IBA:GO_Central.
DR GO; GO:0031288; P:sorocarp morphogenesis; IBA:GO_Central.
DR CDD; cd03263; ABC_subfamily_A; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229:SF205; ABC TRANSPORTER A FAMILY MEMBER 1-RELATED; 1.
DR PANTHER; PTHR19229; ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA; 1.
DR Pfam; PF12698; ABC2_membrane_3; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Membrane; Nucleotide-binding; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..837
FT /note="ABC transporter A family member 8"
FT /id="PRO_0000363840"
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 303..323
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 326..346
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 356..376
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 393..413
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 455..475
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 516..750
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 553..560
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 837 AA; 93818 MW; F99D6D0FEBA8523D CRC64;
MSIGETIHRE FIHLKLLLKK NFLVSIRSYF STIIELLSPI VFVLIFYIIY SYGSAVDYSN
VSYEQNLPNC IVSVENRCIN LMFSPMNSTC TVEIMKILAK NNNMEIYNYP TDTGPLPNLE
NTIGFHGGII AMDSLNSTEQ FILAHPNVTL AVVDFENFPL NFTINGVKPN DSLIGFNDFY
DLSFNVLLNL STSGGFIEPV DYSIPVTTSI QKAIYDFYAI NNQKQIPTIN FDSTQFIEYS
SVNVVSLFGG LFYYCAIMIS FIFLLYKVAF EKEKNLKQGM VMMGLSRSMY WLSWVITSFT
IDLIICLLLI AIGAICKLPF FLGTNFLVLL LNFFLFAISS SSMAFFMLTF IGKTKVAIGI
GMAFFIVGSG LQLTFNSLGS LIFQIIYQTD SNGAAFVRVI LFILPMFHFS KVLTDINDKV
QSYPTSQFKI SDLNDNLDGS QYGMDYLVPT TGQSLAYMFI LVIVYLSLSA IIEYALSGGF
SFKTVKHINV PHFDDQDVAN ATNRSLDPSN KSPFIIRGLS KTFNKFLRPS KSVHALKYLS
LDIQEGTVLG LLGSNGAGKS TTIGILTGIH SPTSGDAIIY GHSVVKDIHS VRKITSVVPQ
DDILWLELTA MEHLHLFAEL KGIPVRERDF QIAKVLEQVK LTKVANDQCS TFSGGMKRRL
SVAIGCIGDP KIIFMDEPTT GLDPRSKRRI YTLVKEIKKD KVIILTSHDM HEIEILAQNL
VILNDGIMVC NGNALQLKTK YGEGYSVQVI AKSLEVIPEI INFVTSSLPY CRFLKQSALQ
LNFGFPINTD PKIIVNFFKR LESITKDENN NLMRDWSISH SNMDDVFIKV SNKPKLQ
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