GenomeNet

Database: UniProt
Entry: ALDH_EMENI
LinkDB: ALDH_EMENI
Original site: ALDH_EMENI 
ID   ALDH_EMENI              Reviewed;         497 AA.
AC   P08157; C8VSL3; Q5BFX6; Q9C1Q6;
DT   01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 2.
DT   28-FEB-2018, entry version 118.
DE   RecName: Full=Aldehyde dehydrogenase;
DE            Short=ALDDH;
DE            Short=ALDH;
DE            EC=1.2.1.3;
GN   Name=aldA; Synonyms=aspA; ORFNames=AN0554;
OS   Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL
OS   194 / M139) (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=227321;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3036652; DOI=10.1016/0378-1119(87)90310-6;
RA   Pickett M., Gwynne D.I., Buxton F.P., Elliott R., Davies R.W.,
RA   Lockington R.A., Scazzocchio C., Sealy-Lewis H.M.;
RT   "Cloning and characterization of the aldA gene of Aspergillus
RT   nidulans.";
RL   Gene 51:217-226(1987).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11102439; DOI=10.1074/jbc.M005769200;
RA   Flipphi M., Mathieu M., Cirpus I., Panozzo C., Felenbok B.;
RT   "Regulation of the aldehyde dehydrogenase gene (aldA) and its role in
RT   the control of the coinducer level necessary for induction of the
RT   ethanol utilization pathway in Aspergillus nidulans.";
RL   J. Biol. Chem. 276:6950-6958(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R.,
RA   Batzoglou S., Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J.,
RA   Kapitonov V., Jurka J., Scazzocchio C., Farman M.L., Butler J.,
RA   Purcell S., Harris S., Braus G.H., Draht O., Busch S., D'Enfert C.,
RA   Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S.,
RA   Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U.,
RA   Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T.,
RA   Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W.,
RA   Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA   Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA   Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA   Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P.,
RA   von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E.,
RA   Fekete E., Flipphi M., Estrada C.G., Geysens S., Goldman G.,
RA   de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K.,
RA   Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S.,
RA   Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E.,
RA   Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A.,
RA   Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P.,
RA   Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R.,
RA   Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I.,
RA   Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B.,
RA   van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N.,
RA   Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J.,
RA   de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W.,
RA   Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.;
RT   "The 2008 update of the Aspergillus nidulans genome annotation: a
RT   community effort.";
RL   Fungal Genet. Biol. 46:S2-13(2009).
CC   -!- CATALYTIC ACTIVITY: An aldehyde + NAD(+) + H(2)O = a carboxylate +
CC       NADH.
CC   -!- PATHWAY: Alcohol metabolism; ethanol degradation; acetate from
CC       ethanol: step 2/2.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000305}.
DR   EMBL; M16197; AAA33293.1; -; Genomic_DNA.
DR   EMBL; AF260123; AAK18072.1; -; Genomic_DNA.
DR   EMBL; AACD01000007; EAA66653.1; -; Genomic_DNA.
DR   EMBL; BN001308; CBF89245.1; -; Genomic_DNA.
DR   PIR; A29055; A29055.
DR   RefSeq; XP_658158.1; XM_653066.1.
DR   ProteinModelPortal; P08157; -.
DR   SMR; P08157; -.
DR   BioGrid; 1957104; 1.
DR   STRING; 162425.CADANIAP00002125; -.
DR   PRIDE; P08157; -.
DR   EnsemblFungi; CADANIAT00002125; CADANIAP00002125; CADANIAG00002125.
DR   EnsemblFungi; EAA66653; EAA66653; AN0554.2.
DR   GeneID; 2876330; -.
DR   KEGG; ani:AN0554.2; -.
DR   HOGENOM; HOG000271505; -.
DR   InParanoid; P08157; -.
DR   KO; K00128; -.
DR   OMA; TFVQEDV; -.
DR   OrthoDB; EOG092C1LLH; -.
DR   UniPathway; UPA00780; UER00768.
DR   Proteomes; UP000000560; Chromosome VIII.
DR   Proteomes; UP000005890; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IDA:AspGD.
DR   GO; GO:0005622; C:intracellular; IDA:AspGD.
DR   GO; GO:0004029; F:aldehyde dehydrogenase (NAD) activity; IMP:AspGD.
DR   GO; GO:0004030; F:aldehyde dehydrogenase [NAD(P)+] activity; IMP:AspGD.
DR   GO; GO:0046187; P:acetaldehyde catabolic process; IMP:AspGD.
DR   GO; GO:0019413; P:acetate biosynthetic process; IMP:AspGD.
DR   GO; GO:0045991; P:carbon catabolite activation of transcription; IMP:AspGD.
DR   GO; GO:0071470; P:cellular response to osmotic stress; IEP:AspGD.
DR   GO; GO:0006068; P:ethanol catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006067; P:ethanol metabolic process; IMP:AspGD.
DR   GO; GO:0006567; P:threonine catabolic process; IMP:AspGD.
DR   Gene3D; 3.40.309.10; -; 1.
DR   Gene3D; 3.40.605.10; -; 2.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; SSF53720; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Complete proteome; NAD; Oxidoreductase; Reference proteome.
FT   CHAIN         1    497       Aldehyde dehydrogenase.
FT                                /FTId=PRO_0000056438.
FT   NP_BIND     241    246       NAD. {ECO:0000250}.
FT   ACT_SITE    264    264       Proton acceptor. {ECO:0000255|PROSITE-
FT                                ProRule:PRU10007, ECO:0000255|PROSITE-
FT                                ProRule:PRU10008}.
FT   ACT_SITE    298    298       Nucleophile. {ECO:0000255|PROSITE-
FT                                ProRule:PRU10007, ECO:0000255|PROSITE-
FT                                ProRule:PRU10008}.
FT   SITE        165    165       Transition state stabilizer.
FT                                {ECO:0000250}.
FT   CONFLICT    191    191       E -> Q (in Ref. 1; AAA33293).
FT                                {ECO:0000305}.
FT   CONFLICT    208    208       G -> P (in Ref. 1; AAA33293).
FT                                {ECO:0000305}.
FT   CONFLICT    247    247       R -> P (in Ref. 1; AAA33293).
FT                                {ECO:0000305}.
FT   CONFLICT    409    409       E -> V (in Ref. 1; AAA33293).
FT                                {ECO:0000305}.
SQ   SEQUENCE   497 AA;  54139 MW;  9C6CFC62731A25BD CRC64;
     MSDLFTTIET PVIKYEQPLG LFINNEFVKG VEGKTFQVIN PSNEKVITSV HEATEKDVDV
     AVAAARAAFE GPWRQVTPSE RGILINKLAD LMERDIDTLA AIESLDNGKA FTMAKVDLAN
     SIGCLRYYAG WADKIHGQTI DTNPETLTYT RHEPVGVCGQ IIPWNFPLLM WSWKIGPAVA
     AGNTVVLKTA EQTPLSALYA AKLIKEAGFP AGVINVISGF GRTAGAAISS HMDIDKVAFT
     GSTLVGRTIL QAAAKSNLKK VTLELGGKSP NIVFDDADID NAISWANFGI FFNHGQCCCA
     GSRILVQEGI YDKFVARFKE RAQKNKVGNP FEQDTFQGPQ VSQLQFDRIM EYINHGKKAG
     ATVATGGDRH GNEGYFIQPT VFTDVTSDMK IAQEEIFGPV VTIQKFKDEA EAIKIGNSTD
     YGLAAAVHTK NVNTAIRVSN ALKAGTVWIN NYNMISYQAP FGGFKQSGLG RELGSYALEN
     YTQIKTVHYR LGDALFA
//
DBGET integrated database retrieval system