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Database: UniProt
Entry: AN34C_HUMAN
LinkDB: AN34C_HUMAN
Original site: AN34C_HUMAN 
ID   AN34C_HUMAN             Reviewed;         535 AA.
AC   P0C6C1; H3BNM1;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-JUN-2013, sequence version 2.
DT   27-MAR-2024, entry version 105.
DE   RecName: Full=Ankyrin repeat domain-containing protein 34C;
GN   Name=ANKRD34C;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA   Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA   Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA   Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA   O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA   Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA   Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human chromosome
RT   15.";
RL   Nature 440:671-675(2006).
CC   -!- SIMILARITY: Belongs to the ANKRD34 family. {ECO:0000305}.
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DR   EMBL; AC011797; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS53965.1; -.
DR   RefSeq; NP_001139813.1; NM_001146341.1.
DR   AlphaFoldDB; P0C6C1; -.
DR   SMR; P0C6C1; -.
DR   BioGRID; 133634; 34.
DR   STRING; 9606.ENSP00000401089; -.
DR   GlyCosmos; P0C6C1; 1 site, 1 glycan.
DR   GlyGen; P0C6C1; 2 sites, 1 O-linked glycan (2 sites).
DR   iPTMnet; P0C6C1; -.
DR   PhosphoSitePlus; P0C6C1; -.
DR   BioMuta; ANKRD34C; -.
DR   DMDM; 519668660; -.
DR   MassIVE; P0C6C1; -.
DR   PaxDb; 9606-ENSP00000401089; -.
DR   PeptideAtlas; P0C6C1; -.
DR   ProteomicsDB; 41238; -.
DR   ProteomicsDB; 52326; -.
DR   Antibodypedia; 68063; 65 antibodies from 11 providers.
DR   DNASU; 390616; -.
DR   Ensembl; ENST00000421388.4; ENSP00000401089.2; ENSG00000235711.5.
DR   GeneID; 390616; -.
DR   KEGG; hsa:390616; -.
DR   MANE-Select; ENST00000421388.4; ENSP00000401089.2; NM_001146341.2; NP_001139813.1.
DR   UCSC; uc059mho.1; human.
DR   AGR; HGNC:33888; -.
DR   CTD; 390616; -.
DR   GeneCards; ANKRD34C; -.
DR   HGNC; HGNC:33888; ANKRD34C.
DR   HPA; ENSG00000235711; Tissue enhanced (brain).
DR   neXtProt; NX_P0C6C1; -.
DR   OpenTargets; ENSG00000235711; -.
DR   VEuPathDB; HostDB:ENSG00000235711; -.
DR   eggNOG; ENOG502QW3G; Eukaryota.
DR   GeneTree; ENSGT00880000138051; -.
DR   HOGENOM; CLU_042805_0_0_1; -.
DR   InParanoid; P0C6C1; -.
DR   OMA; VACMSTH; -.
DR   OrthoDB; 5397973at2759; -.
DR   PhylomeDB; P0C6C1; -.
DR   TreeFam; TF331155; -.
DR   PathwayCommons; P0C6C1; -.
DR   BioGRID-ORCS; 390616; 9 hits in 1134 CRISPR screens.
DR   GenomeRNAi; 390616; -.
DR   Pharos; P0C6C1; Tdark.
DR   PRO; PR:P0C6C1; -.
DR   Proteomes; UP000005640; Chromosome 15.
DR   RNAct; P0C6C1; Protein.
DR   Bgee; ENSG00000235711; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 67 other cell types or tissues.
DR   Genevisible; P0C6C1; HS.
DR   GO; GO:0071546; C:pi-body; IBA:GO_Central.
DR   GO; GO:0034587; P:piRNA processing; IBA:GO_Central.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   InterPro; IPR042637; AN34A/B/C.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   PANTHER; PTHR24156; ANK_REP_REGION DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR24156:SF6; ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 34C; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   SMART; SM00248; ANK; 4.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 2.
PE   3: Inferred from homology;
KW   ANK repeat; Phosphoprotein; Reference proteome; Repeat.
FT   CHAIN           1..535
FT                   /note="Ankyrin repeat domain-containing protein 34C"
FT                   /id="PRO_0000319104"
FT   REPEAT          10..39
FT                   /note="ANK 1"
FT   REPEAT          43..80
FT                   /note="ANK 2"
FT   REPEAT          84..114
FT                   /note="ANK 3"
FT   REPEAT          118..147
FT                   /note="ANK 4"
FT   REGION          159..181
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          214..237
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          381..444
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        214..234
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        412..435
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         301
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8BLB8"
FT   MOD_RES         447
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8BLB8"
FT   VARIANT         369
FT                   /note="P -> R (in dbSNP:rs410400)"
FT                   /id="VAR_038953"
FT   VARIANT         427
FT                   /note="P -> H (in dbSNP:rs449340)"
FT                   /id="VAR_038954"
FT   VARIANT         442
FT                   /note="L -> I (in dbSNP:rs422777)"
FT                   /id="VAR_038955"
SQ   SEQUENCE   535 AA;  58256 MW;  8B2757427F9F3686 CRC64;
     MMDDDTELRT DGNSLLKAVW LGRLRLTRLL LEGGAYINES NDKGETALMV ACITKHVDQQ
     SISKSKMVKY LLDNRADPNI QDKSGKTALI HACIRRAGGE VVSLLLENGA DPSLEDRTGA
     SALVYAINAD DKDALKHLLD ACKAKGKEVI IITTDKSSSG TKTTKQYLNV PPSPKVEDRH
     SPPLCASPSD IELKALGLDS PLTEKEDDFF SLQAGHPSSC NTSKAVNEPG SPTRKVSNLK
     RARLPQLKRL QSEPWGLIAP SVLAASTRQD ETHGASTDNE VIKSISDISF PKRGPLSRTN
     SIDSKDPTLF HTVTEQVLKI PVSSAPASWK AAYEKGQAPH PRLARRGTLP VDQEKCGMGP
     SGPSALKEPA SLKWLENDLY DLDIQPGPDP PNSISLESGK GPLDRKKLNS SHLSLFHGSR
     ESLDTVPSTS PSSARRRPPH LLERRGSGTL LLDRISHTRP GFLPPLNVNL NPPIPDIRSS
     SKPSCSLASG LKSMVPVAPS SPKRVDLRSK KKLLRRHSMQ IEQMKQLSDF EEIMT
//
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