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Database: UniProt
Entry: APEB_MYCLE
LinkDB: APEB_MYCLE
Original site: APEB_MYCLE 
ID   APEB_MYCLE              Reviewed;         426 AA.
AC   Q50022; O08111;
DT   24-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT   24-OCT-2001, sequence version 2.
DT   22-NOV-2017, entry version 102.
DE   RecName: Full=Probable M18 family aminopeptidase 2;
DE            EC=3.4.11.-;
GN   Name=apeB; Synonyms=pepC, pepX; OrderedLocusNames=ML2213;
GN   ORFNames=MLCB5.29;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Smith D.R., Robison K.;
RL   Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the peptidase M18 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA62998.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=CAB08404.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=CAC31168.1; Type=Erroneous initiation; Evidence={ECO:0000305};
DR   EMBL; U15182; AAA62998.1; ALT_INIT; Genomic_DNA.
DR   EMBL; Z95151; CAB08404.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AL583924; CAC31168.1; ALT_INIT; Genomic_DNA.
DR   PIR; H87185; H87185.
DR   RefSeq; WP_010908772.1; NC_002677.1.
DR   ProteinModelPortal; Q50022; -.
DR   SMR; Q50022; -.
DR   MEROPS; M18.002; -.
DR   EnsemblBacteria; CAC31168; CAC31168; CAC31168.
DR   Leproma; ML2213; -.
DR   eggNOG; ENOG4105DFM; Bacteria.
DR   eggNOG; COG1362; LUCA.
DR   HOGENOM; HOG000253244; -.
DR   OrthoDB; POG091H01I4; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   HAMAP; MF_00467; Aminopeptidase_M18_2; 1.
DR   InterPro; IPR022984; M18_aminopeptidase_2.
DR   InterPro; IPR001948; Peptidase_M18.
DR   InterPro; IPR023367; Peptidase_M42_dom2.
DR   PANTHER; PTHR28570; PTHR28570; 1.
DR   Pfam; PF02127; Peptidase_M18; 1.
DR   PRINTS; PR00932; AMINO1PTASE.
DR   SUPFAM; SSF101821; SSF101821; 1.
PE   3: Inferred from homology;
KW   Aminopeptidase; Complete proteome; Hydrolase; Metal-binding;
KW   Metalloprotease; Protease; Reference proteome; Zinc.
FT   CHAIN         1    426       Probable M18 family aminopeptidase 2.
FT                                /FTId=PRO_0000173463.
FT   METAL        79     79       Zinc. {ECO:0000255}.
FT   METAL       156    156       Zinc. {ECO:0000255}.
FT   METAL       399    399       Zinc. {ECO:0000255}.
SQ   SEQUENCE   426 AA;  45594 MW;  582ADDD29C3A0A53 CRC64;
     MPASAADLCE FINASPSPFH VCATVAGRLL DAGYAELSEV ERWPDHPGRY FIVRAGSLVA
     WSAGQGVKAH APFRIVGAHT DSPNLRVKQH PDLLVAGWRV VALQPYGGAW LNSWLDRDLG
     VSGRLSVRSA GKGSEITDRL VRIDDPILRV PQLAIHLAED RKSLTLDPQR HVNAVWGVGD
     KAGSLLEYVA ERTGVAVADV LAVDLMTHDL VPSMVIGADA NLLSAPRLDN QVSCYAGMEA
     LLASVPHDCL PVLALFDHEE VGSTSDRGAR SNLLSTVLER IVLAAGGGRD DYLRRLPASL
     LVSADMAHAT HPNYPECHEP SHLIEVNAGP VLKVHPNLRY ATDGRTAAAF EVACQQAGVR
     LQRYEHRADR PCGSTIGPLA SARTGIPTVD VGAAQLAMHS ARELMGAHDV AVYSAALQAF
     FSADLF
//
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