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Database: UniProt
Entry: APEB_PSEAE
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Original site: APEB_PSEAE 
ID   APEB_PSEAE              Reviewed;         429 AA.
AC   Q9HYZ3;
DT   24-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   05-JUL-2017, entry version 98.
DE   RecName: Full=Probable M18 family aminopeptidase 2;
DE            EC=3.4.11.-;
GN   Name=apeB; OrderedLocusNames=PA3247;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 /
OS   JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 /
RC   1C / PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T.,
RA   Reizer J., Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an
RT   opportunistic pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the peptidase M18 family. {ECO:0000305}.
DR   EMBL; AE004091; AAG06635.1; -; Genomic_DNA.
DR   PIR; A83240; A83240.
DR   RefSeq; NP_251937.1; NC_002516.2.
DR   RefSeq; WP_003114800.1; NC_002516.2.
DR   PDB; 2IJZ; X-ray; 3.00 A; A/B/C/D/E/F/G/H/I/J/K/L=2-429.
DR   PDB; 3WT4; X-ray; 2.30 A; A/B/C/D=1-429.
DR   PDB; 4NJQ; X-ray; 2.70 A; A/B/C/D=1-429.
DR   PDB; 4NJR; X-ray; 2.30 A; A/B/C/D=1-429.
DR   PDB; 4OID; X-ray; 2.30 A; A/B/C/D=1-429.
DR   PDB; 4OIW; X-ray; 2.44 A; A/B/C/D/E/F=1-429.
DR   PDBsum; 2IJZ; -.
DR   PDBsum; 3WT4; -.
DR   PDBsum; 4NJQ; -.
DR   PDBsum; 4NJR; -.
DR   PDBsum; 4OID; -.
DR   PDBsum; 4OIW; -.
DR   ProteinModelPortal; Q9HYZ3; -.
DR   SMR; Q9HYZ3; -.
DR   STRING; 208964.PA3247; -.
DR   MEROPS; M18.002; -.
DR   PaxDb; Q9HYZ3; -.
DR   EnsemblBacteria; AAG06635; AAG06635; PA3247.
DR   GeneID; 882410; -.
DR   KEGG; pae:PA3247; -.
DR   PATRIC; fig|208964.12.peg.3394; -.
DR   PseudoCAP; PA3247; -.
DR   eggNOG; ENOG4105DFM; Bacteria.
DR   eggNOG; COG1362; LUCA.
DR   HOGENOM; HOG000253244; -.
DR   InParanoid; Q9HYZ3; -.
DR   KO; K01267; -.
DR   OMA; CFDHEEI; -.
DR   PhylomeDB; Q9HYZ3; -.
DR   EvolutionaryTrace; Q9HYZ3; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0070006; F:metalloaminopeptidase activity; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006518; P:peptide metabolic process; IBA:GO_Central.
DR   HAMAP; MF_00467; Aminopeptidase_M18_2; 1.
DR   InterPro; IPR022984; M18_aminopeptidase_2.
DR   InterPro; IPR001948; Peptidase_M18.
DR   Pfam; PF02127; Peptidase_M18; 1.
DR   PRINTS; PR00932; AMINO1PTASE.
PE   1: Evidence at protein level;
KW   3D-structure; Aminopeptidase; Complete proteome; Hydrolase;
KW   Metal-binding; Metalloprotease; Protease; Reference proteome; Zinc.
FT   CHAIN         1    429       Probable M18 family aminopeptidase 2.
FT                                /FTId=PRO_0000173465.
FT   METAL        82     82       Zinc. {ECO:0000255}.
FT   METAL       156    156       Zinc. {ECO:0000255}.
FT   METAL       401    401       Zinc. {ECO:0000255}.
FT   HELIX         3     14       {ECO:0000244|PDB:3WT4}.
FT   HELIX        19     32       {ECO:0000244|PDB:3WT4}.
FT   STRAND       36     38       {ECO:0000244|PDB:4NJQ}.
FT   STRAND       51     56       {ECO:0000244|PDB:3WT4}.
FT   TURN         57     59       {ECO:0000244|PDB:3WT4}.
FT   STRAND       60     65       {ECO:0000244|PDB:3WT4}.
FT   HELIX        71     74       {ECO:0000244|PDB:3WT4}.
FT   STRAND       76     83       {ECO:0000244|PDB:3WT4}.
FT   STRAND       87     98       {ECO:0000244|PDB:3WT4}.
FT   STRAND      101    111       {ECO:0000244|PDB:3WT4}.
FT   HELIX       115    117       {ECO:0000244|PDB:3WT4}.
FT   STRAND      122    132       {ECO:0000244|PDB:3WT4}.
FT   STRAND      135    142       {ECO:0000244|PDB:3WT4}.
FT   HELIX       155    157       {ECO:0000244|PDB:3WT4}.
FT   HELIX       161    163       {ECO:0000244|PDB:3WT4}.
FT   HELIX       169    172       {ECO:0000244|PDB:3WT4}.
FT   STRAND      176    179       {ECO:0000244|PDB:3WT4}.
FT   HELIX       188    200       {ECO:0000244|PDB:3WT4}.
FT   STRAND      205    216       {ECO:0000244|PDB:3WT4}.
FT   STRAND      221    224       {ECO:0000244|PDB:3WT4}.
FT   STRAND      229    232       {ECO:0000244|PDB:3WT4}.
FT   HELIX       235    250       {ECO:0000244|PDB:3WT4}.
FT   STRAND      256    263       {ECO:0000244|PDB:3WT4}.
FT   HELIX       265    267       {ECO:0000244|PDB:3WT4}.
FT   STRAND      274    278       {ECO:0000244|PDB:3WT4}.
FT   HELIX       279    285       {ECO:0000244|PDB:3WT4}.
FT   STRAND      290    292       {ECO:0000244|PDB:4OID}.
FT   HELIX       293    298       {ECO:0000244|PDB:3WT4}.
FT   STRAND      302    306       {ECO:0000244|PDB:3WT4}.
FT   HELIX       317    319       {ECO:0000244|PDB:3WT4}.
FT   HELIX       322    324       {ECO:0000244|PDB:4NJQ}.
FT   STRAND      327    329       {ECO:0000244|PDB:2IJZ}.
FT   STRAND      333    335       {ECO:0000244|PDB:3WT4}.
FT   TURN        338    341       {ECO:0000244|PDB:3WT4}.
FT   HELIX       346    358       {ECO:0000244|PDB:3WT4}.
FT   STRAND      364    366       {ECO:0000244|PDB:3WT4}.
FT   HELIX       379    384       {ECO:0000244|PDB:3WT4}.
FT   TURN        385    387       {ECO:0000244|PDB:3WT4}.
FT   STRAND      390    394       {ECO:0000244|PDB:3WT4}.
FT   STRAND      396    399       {ECO:0000244|PDB:3WT4}.
FT   STRAND      402    408       {ECO:0000244|PDB:3WT4}.
FT   HELIX       411    423       {ECO:0000244|PDB:3WT4}.
SQ   SEQUENCE   429 AA;  46659 MW;  FCBF80A93F67CBE3 CRC64;
     MRAELNQGLI DFLKASPTPF HATASLARRL EAAGYRRLDE RDAWHTETGG RYYVTRNDSS
     LIAIRLGRRS PLESGFRLVG AHTDSPCLRV KPNPEIARNG FLQLGVEVYG GALFAPWFDR
     DLSLAGRVTF RANGKLESRL VDFRKAIAVI PNLAIHLNRA ANEGWPINAQ NELPPIIAQL
     APGEAADFRL LLDEQLLREH GITADVVLDY ELSFYDTQSA AVVGLNDEFI AGARLDNLLS
     CHAGLEALLN AEGDENCILV CTDHEEVGSC SHCGADGPFL EQVLRRLLPE GDAFSRAIQR
     SLLVSADNAH GVHPNYADRH DANHGPALNG GPVIKINSNQ RYATNSETAG FFRHLCQDSE
     VPVQSFVTRS DMGCGSTIGP ITASQVGVRT VDIGLPTFAM HSIRELAGSH DLAHLVKVLG
     AFYASSELP
//
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