ID APOA4_PAPAN Reviewed; 401 AA.
AC Q28758;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 22-FEB-2023, entry version 86.
DE RecName: Full=Apolipoprotein A-IV;
DE Short=Apo-AIV;
DE Short=ApoA-IV;
DE AltName: Full=Apolipoprotein A4;
DE Flags: Precursor; Fragment;
GN Name=APOA4;
OS Papio anubis (Olive baboon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Papio.
OX NCBI_TaxID=9555;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND POLYMORPHISM.
RC TISSUE=Intestine;
RX PubMed=8101842; DOI=10.1016/s0021-9258(18)82308-0;
RA Hixson J.E., Kammerer C.M., Mott G.E., Britten M.L., Birnbaum S.,
RA Powers P.K., Vandeberg J.L.;
RT "Baboon apolipoprotein A-IV. Identification of Lys-76-->Glu that
RT distinguishes two common isoforms and detection of length polymorphisms at
RT the carboxyl terminus.";
RL J. Biol. Chem. 268:15667-15673(1993).
CC -!- FUNCTION: May have a role in chylomicrons and VLDL secretion and
CC catabolism. Required for efficient activation of lipoprotein lipase by
CC ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL
CC and chylomicrons.
CC -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:P06727}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Synthesized primarily in the intestine and secreted
CC in plasma.
CC -!- DOMAIN: Nine of the thirteen 22-amino acid tandem repeats (each 22-mer
CC is actually a tandem array of two, A and B, related 11-mers) occurring
CC in this sequence are predicted to be highly alpha-helical, and many of
CC these helices are amphipathic. They may therefore serve as lipid-
CC binding domains with lecithin:cholesterol acyltransferase (LCAT)
CC activating abilities.
CC -!- PTM: Phosphorylation sites are present in the extracellular medium.
CC {ECO:0000250}.
CC -!- POLYMORPHISM: There are two common APOA-IV isoforms, I (shown here) and
CC E. The I isoform is associated with higher levels of high density
CC lipoprotein-C on a high cholesterol, saturated fat diet.
CC {ECO:0000269|PubMed:8101842}.
CC -!- SIMILARITY: Belongs to the apolipoprotein A1/A4/E family.
CC {ECO:0000305}.
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DR EMBL; L13174; AAA35379.1; -; mRNA.
DR AlphaFoldDB; Q28758; -.
DR SMR; Q28758; -.
DR STRING; 9555.ENSPANP00000011089; -.
DR Proteomes; UP000028761; Unplaced.
DR GO; GO:0042627; C:chylomicron; IEA:UniProtKB-KW.
DR GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
DR Gene3D; 1.20.120.20; Apolipoprotein; 2.
DR InterPro; IPR000074; ApoA_E.
DR PANTHER; PTHR18976; APOLIPOPROTEIN; 1.
DR PANTHER; PTHR18976:SF1; APOLIPOPROTEIN A-IV; 1.
DR Pfam; PF01442; Apolipoprotein; 2.
DR SUPFAM; SSF58113; Apolipoprotein A-I; 2.
PE 2: Evidence at transcript level;
KW Chylomicron; HDL; Lipid transport; Phosphoprotein; Reference proteome;
KW Repeat; Secreted; Signal; Transport.
FT SIGNAL <1..4
FT /evidence="ECO:0000255"
FT CHAIN 5..401
FT /note="Apolipoprotein A-IV"
FT /id="PRO_0000001978"
FT REPEAT 17..38
FT /note="1"
FT REPEAT 44..65
FT /note="2"
FT REPEAT 66..87
FT /note="3"
FT REPEAT 99..120
FT /note="4"
FT REPEAT 121..142
FT /note="5"
FT REPEAT 143..164
FT /note="6"
FT REPEAT 165..186
FT /note="7"
FT REPEAT 187..208
FT /note="8"
FT REPEAT 209..230
FT /note="9"
FT REPEAT 231..252
FT /note="10"
FT REPEAT 253..270
FT /note="11"
FT REPEAT 271..292
FT /note="12"
FT REPEAT 293..314
FT /note="13"
FT REGION 17..314
FT /note="13 X 22 AA approximate tandem repeats"
FT REGION 343..401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 80
FT /note="K -> E (in isoform E)"
FT NON_TER 1
SQ SEQUENCE 401 AA; 46538 MW; 0A76D1284AA9837F CRC64;
GARAEVSADQ VATVMWDYFS QLSSNAKEAV EHLQKSELTQ QLNALFQDKL GEVNTYAGDL
QKKLVPFATE LHERLAKDSK KLKEEIRKEL EEVRARLLPH ANEVSQKIGE NVRELQQRLE
PYTDQLRTQV NTQTEQLRRQ LTPYAQRMER VLRENADSLQ TSLRPHADQL KAKIDQNVEE
LKGRLTPYAD EFKVKIDQTV EELRRSLAPY AQDAQEKLNH QLEGLAFQMK KNAEELKARI
SASAEELRQR LAPLAEDMRG NLRGNTEGLQ KSLAELGGHL DRHVEEFRLR VEPYGENFNK
ALVQQMEQLR QKLGPHAGDV EGHLSFLEKD LRDKVNSFFS TFKEKESQDN TLSLPEPEQQ
QEQQQEQEQQ QEQQEEQQQQ EQQQEQEQQQ EQVQMLAPLE S
//
