ID ATG17_ASPFU Reviewed; 551 AA.
AC Q4X0B0;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE RecName: Full=Autophagy-related protein 17;
GN Name=atg17; ORFNames=AFUA_2G14100;
OS Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 /
OS Af293) (Neosartorya fumigata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- FUNCTION: Autophagy-specific protein that functions in response to
CC autophagy-inducing signals as a scaffold to recruit other ATG proteins
CC to organize pre-autophagosomal structure (PAS) formation. Modulates the
CC timing and magnitude of the autophagy response, such as the size of the
CC sequestering vesicles. Plays particularly a role in pexophagy and
CC nucleophagy (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Preautophagosomal
CC structure membrane {ECO:0000250}; Peripheral membrane protein
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ATG17 family. {ECO:0000305}.
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DR EMBL; AAHF01000001; EAL93705.1; -; Genomic_DNA.
DR RefSeq; XP_755743.1; XM_750650.1.
DR AlphaFoldDB; Q4X0B0; -.
DR SMR; Q4X0B0; -.
DR STRING; 330879.Q4X0B0; -.
DR EnsemblFungi; EAL93705; EAL93705; AFUA_2G14100.
DR GeneID; 3513148; -.
DR KEGG; afm:AFUA_2G14100; -.
DR VEuPathDB; FungiDB:Afu2g14100; -.
DR eggNOG; ENOG502RYHP; Eukaryota.
DR HOGENOM; CLU_028356_0_0_1; -.
DR InParanoid; Q4X0B0; -.
DR OMA; THVWRAN; -.
DR OrthoDB; 1940609at2759; -.
DR Proteomes; UP000002530; Chromosome 2.
DR GO; GO:1990316; C:Atg1/ULK1 kinase complex; IBA:GO_Central.
DR GO; GO:0000407; C:phagophore assembly site; IBA:GO_Central.
DR GO; GO:0034045; C:phagophore assembly site membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0060090; F:molecular adaptor activity; IBA:GO_Central.
DR GO; GO:0030295; F:protein kinase activator activity; IBA:GO_Central.
DR GO; GO:0000045; P:autophagosome assembly; IBA:GO_Central.
DR GO; GO:0044804; P:nucleophagy; IBA:GO_Central.
DR GO; GO:0034727; P:piecemeal microautophagy of the nucleus; IBA:GO_Central.
DR InterPro; IPR007240; Atg17.
DR InterPro; IPR045326; ATG17-like_dom.
DR PANTHER; PTHR28005; AUTOPHAGY-RELATED PROTEIN 17; 1.
DR PANTHER; PTHR28005:SF1; AUTOPHAGY-RELATED PROTEIN 17; 1.
DR Pfam; PF04108; ATG17_like; 1.
PE 3: Inferred from homology;
KW Autophagy; Cytoplasm; Membrane; Reference proteome.
FT CHAIN 1..551
FT /note="Autophagy-related protein 17"
FT /id="PRO_0000124556"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 204..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 502..524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 551 AA; 60950 MW; 2FF58BAF901C3FDF CRC64;
MSSSESSSVS GGGRPDAGRL PGEEQAMPRL DTLISHLVAA KRSLSSINHV WRANEIVTAA
RAALEECVVV SARTAFLRRG LNNQLRLLYS VRTEVEEISL RGRSEFAAVL KDLDDADTRL
RRTLELLRET IVHPAFRPEG EDPKSLHDFV DERGVEELHA ALKSSIDRTT AAQAQLDSSN
HAFDDELLSI KEALGTYRTA AKLASSRSSS SASSSSTSNS SLPSISTMPS MLHSLEMHAQ
EMANLLESLV RHFDLCVTAV KHTEGGGAAA KSITGDMPVG VPVSGRMGSN IEEEINNNLN
APLDPLSNSE YQEMVNVLFK DAAEAEDVVM EIQDRIGEME SVLENVLAQR DALRSIYNAT
TDIYQHLSSL GSTRLPGYIA QAHNFTQVWH EENDRISGGL ADLSDLNSLY NGFLDAYDGL
IVEVARRKHV RQRVEKVLRD TRHKLDQLYE EDVTARETFR VEKGDYLPSD IWPEIGREPM
RIEFRRISGA KVQAVNLQSP NEQEAITDEQ KTANRLAPVE SKDGDEIIPD LPRELVEQAF
ARLKARAKDA T
//
