ID   B0A6Z0_9FIRM            Unreviewed;       702 AA.
AC   B0A6Z0;
DT   26-FEB-2008, integrated into UniProtKB/TrEMBL.
DT   26-FEB-2008, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   RecName: Full=Membrane transport protein MMPL domain-containing protein {ECO:0000259|Pfam:PF03176};
GN   ORFNames=SAMN02745147_1598 {ECO:0000313|EMBL:SKA55354.1};
OS   Intestinibacter bartlettii DSM 16795.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Peptostreptococcaceae;
OC   Intestinibacter.
OX   NCBI_TaxID=445973 {ECO:0000313|EMBL:SKA55354.1, ECO:0000313|Proteomes:UP000190760};
RN   [1] {ECO:0000313|EMBL:SKA55354.1, ECO:0000313|Proteomes:UP000190760}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 16795 {ECO:0000313|EMBL:SKA55354.1,
RC   ECO:0000313|Proteomes:UP000190760};
RA   Peterson S.W.;
RL   Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FUXV01000002; SKA55354.1; -; Genomic_DNA.
DR   RefSeq; WP_007285656.1; NZ_FUXV01000002.1.
DR   AlphaFoldDB; B0A6Z0; -.
DR   STRING; 261299.ERS852493_01593; -.
DR   eggNOG; COG1033; Bacteria.
DR   OrthoDB; 9782006at2; -.
DR   Proteomes; UP000190760; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR004869; MMPL_dom.
DR   PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR   PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR   Pfam; PF03176; MMPL; 2.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        15..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        176..209
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        215..244
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        265..288
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        300..324
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        345..362
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        519..535
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        568..589
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        610..634
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        646..668
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          42..322
FT                   /note="Membrane transport protein MMPL"
FT                   /evidence="ECO:0000259|Pfam:PF03176"
FT   DOMAIN          419..668
FT                   /note="Membrane transport protein MMPL"
FT                   /evidence="ECO:0000259|Pfam:PF03176"
SQ   SEQUENCE   702 AA;  77539 MW;  6C1704D198E54F97 CRC64;
     MRKFYEAIVD HKKTVIVFFT IAMIISALCS TMVNVNYDIN DYLPDGTAST VALDKMNEEY
     DMSIPNARVM VSNLTVAEAL KMKEKLSEID GVDDVTWLDD AIDTDIPLET ADKDTVKNYY
     KDNNALYTVT IDESKRIETV HAIRDLIGEE NSMSGAAVNT AVAAEATTKE VKNIIFLVIP
     ICLAVLFLTS GSWIEPILLL GSIGIAILIN KGSNLMFGTI SFVTNAAGGV LQLAVSMDYS
     IFLLHRFQEM REEGQAPKEA MINALCKSTG SILSSGLTTV IGFAALILMR FKIGPDMGLA
     MAKAIFISLV TVFVLFPVIL LYCYPLIDKT AHKSLLPNFE KFGRFVTKLM VPAVLVFVLF
     IIPCNLGQKE NFFSYGSSQI FSTDTQIGSD TKKIEDIFGK SNNLVLMVPK GDLQKESQLS
     KDLHNMPEVS SILSYVDNAG AEVPMDYVDN DTLSKLISDN YSRLVLTVDA DFEGEKTFAL
     IEEIRALAKT YYGDEYLLAG ESASTYDLMD TITKDNDRVN LIAIGAVFLV LLLSMKSLSI
     PVILVLAIET AIWINLSVPY FTNDFVFYIA YLIISSVQLG ATVDYAILLT SRYMEVRETA
     SRKDTVVETL RSTTVSIMTS ASILTIAGIL LWKVSTHGVL SQLGHLLARG TALSTVIVLF
     VIPGMLYIGD KLVQKTTVGS KFYNEKEVSS YKKKKYEDWE LN
//