ID   KTHY_CHLT2              Reviewed;         203 AA.
AC   B0B9T8;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 1.
DT   01-MAY-2013, entry version 36.
DE   RecName: Full=Thymidylate kinase;
DE            EC=2.7.4.9;
DE   AltName: Full=dTMP kinase;
GN   Name=tmk; OrderedLocusNames=CTL0440;
OS   Chlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=471472;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=434/Bu / ATCC VR-902B;
RX   PubMed=18032721; DOI=10.1101/gr.7020108;
RA   Thomson N.R., Holden M.T.G., Carder C., Lennard N., Lockey S.J.,
RA   Marsh P., Skipp P., O'Connor C.D., Goodhead I., Norbertzcak H.,
RA   Harris B., Ormond D., Rance R., Quail M.A., Parkhill J.,
RA   Stephens R.S., Clarke I.N.;
RT   "Chlamydia trachomatis: genome sequence analysis of lymphogranuloma
RT   venereum isolates.";
RL   Genome Res. 18:161-171(2008).
CC   -!- FUNCTION: Phosphorylation of dTMP to form dTDP in both de novo and
CC       salvage pathways of dTTP synthesis (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + dTMP = ADP + dTDP.
CC   -!- SIMILARITY: Belongs to the thymidylate kinase family.
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DR   EMBL; AM884176; CAP03879.1; -; Genomic_DNA.
DR   RefSeq; YP_001654516.1; NC_010287.1.
DR   ProteinModelPortal; B0B9T8; -.
DR   STRING; 471472.CTL0440; -.
DR   EnsemblBacteria; CAP03879; CAP03879; CTL0440.
DR   GeneID; 5858199; -.
DR   KEGG; ctb:CTL0440; -.
DR   PATRIC; 20376410; VBIChlTra32542_0475.
DR   eggNOG; COG0125; -.
DR   HOGENOM; HOG000229078; -.
DR   KO; K00943; -.
DR   OMA; ITLEGPE; -.
DR   ProtClustDB; PRK00698; -.
DR   BioCyc; CTRA471472:GJ9M-461-MONOMER; -.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0004798; F:thymidylate kinase activity; IEA:HAMAP.
DR   GO; GO:0006233; P:dTDP biosynthetic process; IEA:InterPro.
DR   GO; GO:0006235; P:dTTP biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00165; Thymidylate_kinase; 1; -.
DR   InterPro; IPR018095; Thymidylate_kin_CS.
DR   InterPro; IPR018094; Thymidylate_kinase.
DR   PANTHER; PTHR10344; PTHR10344; 1.
DR   TIGRFAMs; TIGR00041; DTMP_kinase; 1.
DR   PROSITE; PS01331; THYMIDYLATE_KINASE; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Kinase; Nucleotide biosynthesis;
KW   Nucleotide-binding; Transferase.
FT   CHAIN         1    203       Thymidylate kinase.
FT                                /FTId=PRO_1000097386.
FT   NP_BIND       7     14       ATP (Potential).
SQ   SEQUENCE   203 AA;  22457 MW;  3DB40CD0B522027C CRC64;
     MFIVVEGGEG AGKTQFIQAL SKRLIEEGRE IVTTREPGGC SLGDSVRGLL LDPEQKISPY
     AELLLFLAAR AQHIQEKIIP ALKSGKTVIS DRFHDSTIVY QGIAGGLGES FVTNLCYHVV
     GDKPFLPDII FLLDIPAREG LLRKARQKHL DKFEQKPQIF HQSVREGFLA LAEKAPDRYK
     VLDALLPTEA SVDQALLQIR ALI
//