ID B0BMH1_XENTR Unreviewed; 450 AA.
AC B0BMH1;
DT 26-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 26-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=Keratin 12, gene 5 {ECO:0000313|RefSeq:NP_001116496.1};
DE SubName: Full=Krt12 protein {ECO:0000313|EMBL:AAI58427.1};
GN Name=krt12.5 {ECO:0000313|RefSeq:NP_001116496.1,
GN ECO:0000313|Xenbase:XB-GENE-1219321};
GN Synonyms=k12 {ECO:0000313|RefSeq:NP_001116496.1}, krt12
GN {ECO:0000313|EMBL:AAI58427.1, ECO:0000313|RefSeq:NP_001116496.1},
GN krt12.1 {ECO:0000313|RefSeq:NP_001116496.1}, Krt12.5.S
GN {ECO:0000313|RefSeq:NP_001116496.1}, xk81b2
GN {ECO:0000313|RefSeq:NP_001116496.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:AAI58427.1};
RN [1] {ECO:0000313|RefSeq:NP_001116496.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAI58427.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000313|EMBL:AAI58427.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001116496.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR EMBL; BC158426; AAI58427.1; -; mRNA.
DR RefSeq; NP_001116496.1; NM_001123024.1.
DR GeneID; 100144436; -.
DR KEGG; xtr:100144436; -.
DR AGR; Xenbase:XB-GENE-1219321; -.
DR CTD; 100144436; -.
DR Xenbase; XB-GENE-1219321; krt12.5.
DR OMA; HEEXLAG; -.
DR OrthoDB; 4640531at2759; -.
DR Proteomes; UP000008143; Chromosome 10.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; INTERMEDIATE FILAMENT; 1.
DR PANTHER; PTHR23239:SF369; KERATIN, TYPE I CYTOSKELETAL 12; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Keratin {ECO:0000313|RefSeq:NP_001116496.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143}.
FT DOMAIN 85..400
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 403..425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 89..123
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 185..226
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 298..392
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 450 AA; 48986 MW; 1E771B53CE62FAB4 CRC64;
MSLRSSSSYS VQSKSVSGGG GFGSGYGASF GGGSFSGGSY GGSSFGGGFG AGFGGGAASG
FSASSAGGFG AASASSSFSS FGGSDKQTMQ NLNDRLAAYL EKVRALEAAN ADLELKIREW
YEKQRTSGIG AGAKDFSKYF DIITDLRSKI LFATIDNSRV VLQIDNAKLA ADDFRLKFEN
ELALRQSVEA DINGLRRVLD ELTLARGDLE MQIESLTEEL AYLKKNHEEE MSIAKSSAAG
QVTVEMDAAP GTDLTNILNN MRADYETLAE KNRRDAELWF NQKSGELKKE ILTGVELVQS
SKSEISDLRR SLQSLEIELQ SQLAMKKSLE DSLAETDGRY GAQLQNIQLS IRSLEEQLLQ
IRSDMERQNM EYKQLLDIKT RLEMEIETYR RLLEGELSSS SSSVQVITSQ SSSSSKKDPS
KTRKVKTIVE EVVDGKVVSS RVEEVEENVK
//
