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Database: UniProt
Entry: B0CCR3
LinkDB: B0CCR3
Original site: B0CCR3 
ID   COBQ_ACAM1              Reviewed;         497 AA.
AC   B0CCR3;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 1.
DT   26-NOV-2014, entry version 52.
DE   RecName: Full=Cobyric acid synthase {ECO:0000255|HAMAP-Rule:MF_00028};
GN   Name=cobQ {ECO:0000255|HAMAP-Rule:MF_00028};
GN   OrderedLocusNames=AM1_4245;
OS   Acaryochloris marina (strain MBIC 11017).
OC   Bacteria; Cyanobacteria; Oscillatoriophycideae; Chroococcales;
OC   Acaryochloris.
OX   NCBI_TaxID=329726;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MBIC 11017;
RX   PubMed=18252824; DOI=10.1073/pnas.0709772105;
RA   Swingley W.D., Chen M., Cheung P.C., Conrad A.L., Dejesa L.C., Hao J.,
RA   Honchak B.M., Karbach L.E., Kurdoglu A., Lahiri S., Mastrian S.D.,
RA   Miyashita H., Page L., Ramakrishna P., Satoh S., Sattley W.M.,
RA   Shimada Y., Taylor H.L., Tomo T., Tsuchiya T., Wang Z.T., Raymond J.,
RA   Mimuro M., Blankenship R.E., Touchman J.W.;
RT   "Niche adaptation and genome expansion in the chlorophyll d-producing
RT   cyanobacterium Acaryochloris marina.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:2005-2010(2008).
CC   -!- FUNCTION: Catalyzes amidations at positions B, D, E, and G on
CC       adenosylcobyrinic A,C-diamide. NH(2) groups are provided by
CC       glutamine, and one molecule of ATP is hydrogenolyzed for each
CC       amidation. {ECO:0000255|HAMAP-Rule:MF_00028}.
CC   -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_00028}.
CC   -!- SIMILARITY: Belongs to the CobB/CobQ family. CobQ subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_00028}.
CC   -!- SIMILARITY: Contains 1 GATase cobBQ-type domain.
CC       {ECO:0000255|HAMAP-Rule:MF_00028}.
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DR   EMBL; CP000828; ABW29225.1; -; Genomic_DNA.
DR   RefSeq; YP_001518542.1; NC_009925.1.
DR   ProteinModelPortal; B0CCR3; -.
DR   STRING; 329726.AM1_4245; -.
DR   EnsemblBacteria; ABW29225; ABW29225; AM1_4245.
DR   GeneID; 5683048; -.
DR   KEGG; amr:AM1_4245; -.
DR   PATRIC; 20622594; VBIAcaMar40141_3919.
DR   eggNOG; COG1492; -.
DR   HOGENOM; HOG000224803; -.
DR   KO; K02232; -.
DR   OMA; YPRTSNH; -.
DR   OrthoDB; EOG6M9F07; -.
DR   BioCyc; AMAR329726:GCZJ-4232-MONOMER; -.
DR   UniPathway; UPA00148; -.
DR   GO; GO:0015420; F:cobalamin-transporting ATPase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-HAMAP.
DR   Gene3D; 3.40.50.300; -; 1.
DR   Gene3D; 3.40.50.880; -; 1.
DR   HAMAP; MF_00028; CobQ; 1.
DR   InterPro; IPR029062; Class_I_gatase-like.
DR   InterPro; IPR017929; CobB/CobQ_GATase.
DR   InterPro; IPR002586; CobQ/CobB/MinD/ParA_Nub-bd_dom.
DR   InterPro; IPR004459; CobQ_synth.
DR   InterPro; IPR011698; GATase_3.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF01656; CbiA; 1.
DR   Pfam; PF07685; GATase_3; 1.
DR   SUPFAM; SSF52317; SSF52317; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00313; cobQ; 1.
DR   PROSITE; PS51274; GATASE_COBBQ; 1.
PE   3: Inferred from homology;
KW   Cobalamin biosynthesis; Complete proteome; Glutamine amidotransferase;
KW   Reference proteome.
FT   CHAIN         1    497       Cobyric acid synthase.
FT                                /FTId=PRO_0000332315.
FT   DOMAIN      250    445       GATase cobBQ-type. {ECO:0000255|HAMAP-
FT                                Rule:MF_00028}.
FT   ACT_SITE    331    331       Nucleophile. {ECO:0000255|HAMAP-
FT                                Rule:MF_00028}.
FT   ACT_SITE    437    437       {ECO:0000255|HAMAP-Rule:MF_00028}.
SQ   SEQUENCE   497 AA;  54480 MW;  0AFACCCF3AC2D4AC CRC64;
     MGAIMVVGTT SHAGKSIMAA VICRMLKRKG YQVTPFKGQN MALNAYVTNA GDEIGHAQAV
     QAWAAGLEPR VEMNPILLKP QGDMTSQVIL NGKAVGRTQA ADYYRDYFDR GWQAITTALV
     TLQQEFDWIV CEGAGSPAEI NLKHRDLTNM RVAKHLNAPT LLVADIDRGG VFAHIVGTLE
     LLDPDERALI KGFVINKFRG QRSLLESGIT WLEERTGIPV VGVIPWLEHS LPAEDSLDLF
     ERRRTKPNAE VTIAVIRLPR ISNFTDFDPL EAEPSVRLQF VGPNQPLGQP DAVIVPGSKT
     TISDLQQLQV SSMADQLRAY SQAGGMVLGI CGGLQMLGQT ISDPMGTEGP PGEFAGLGLL
     PLQTTMSGDK ITRQRQAQIT LPSDCSALGE DARTIQGYEI HQGQTQVLQP EAVQAWFDDP
     ALGVVSCNHR ILGTYLHGIF NNGPWRRVWL NQLRAQKNLL PLPLAIPNYK VYRDHMLDQV
     TDAIAPYLNL QPFLGKA
//
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