ID B0D3R4_LACBS Unreviewed; 1313 AA.
AC B0D3R4;
DT 26-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 26-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE RecName: Full=Vacuolar import and degradation protein 21 {ECO:0000256|ARBA:ARBA00029670};
GN ORFNames=LACBIDRAFT_316023 {ECO:0000313|EMBL:EDR10974.1};
OS Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686) (Bicoloured deceiver)
OS (Laccaria laccata var. bicolor).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Hydnangiaceae; Laccaria.
OX NCBI_TaxID=486041 {ECO:0000313|Proteomes:UP000001194};
RN [1] {ECO:0000313|EMBL:EDR10974.1, ECO:0000313|Proteomes:UP000001194}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 / ATCC MYA-4686 {ECO:0000313|Proteomes:UP000001194};
RX PubMed=18322534; DOI=10.1038/nature06556;
RA Martin F., Aerts A., Ahren D., Brun A., Danchin E.G.J., Duchaussoy F.,
RA Gibon J., Kohler A., Lindquist E., Pereda V., Salamov A., Shapiro H.J.,
RA Wuyts J., Blaudez D., Buee M., Brokstein P., Canbaeck B., Cohen D.,
RA Courty P.E., Coutinho P.M., Delaruelle C., Detter J.C., Deveau A.,
RA DiFazio S., Duplessis S., Fraissinet-Tachet L., Lucic E., Frey-Klett P.,
RA Fourrey C., Feussner I., Gay G., Grimwood J., Hoegger P.J., Jain P.,
RA Kilaru S., Labbe J., Lin Y.C., Legue V., Le Tacon F., Marmeisse R.,
RA Melayah D., Montanini B., Muratet M., Nehls U., Niculita-Hirzel H.,
RA Oudot-Le Secq M.P., Peter M., Quesneville H., Rajashekar B., Reich M.,
RA Rouhier N., Schmutz J., Yin T., Chalot M., Henrissat B., Kuees U.,
RA Lucas S., Van de Peer Y., Podila G.K., Polle A., Pukkila P.J.,
RA Richardson P.M., Rouze P., Sanders I.R., Stajich J.E., Tunlid A.,
RA Tuskan G., Grigoriev I.V.;
RT "The genome of Laccaria bicolor provides insights into mycorrhizal
RT symbiosis.";
RL Nature 452:88-92(2008).
CC -!- FUNCTION: Component of the NuA4 histone acetyltransferase complex which
CC is involved in transcriptional activation of selected genes principally
CC by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is
CC also involved in DNA repair. {ECO:0000256|ARBA:ARBA00025178}.
CC -!- SIMILARITY: Belongs to the EAF1 family.
CC {ECO:0000256|ARBA:ARBA00008913}.
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DR EMBL; DS547096; EDR10974.1; -; Genomic_DNA.
DR RefSeq; XP_001878275.1; XM_001878240.1.
DR STRING; 486041.B0D3R4; -.
DR GeneID; 6073658; -.
DR KEGG; lbc:LACBIDRAFT_316023; -.
DR HOGENOM; CLU_006074_0_0_1; -.
DR InParanoid; B0D3R4; -.
DR OrthoDB; 1334563at2759; -.
DR Proteomes; UP000001194; Unassembled WGS sequence.
DR GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IEA:UniProt.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd00167; SANT; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR014012; HSA_dom.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR PANTHER; PTHR46459:SF1; E1A-BINDING PROTEIN P400; 1.
DR PANTHER; PTHR46459; E1A-BINDING PROTEIN P400-RELATED; 1.
DR Pfam; PF07529; HSA; 1.
DR Pfam; PF13921; Myb_DNA-bind_6; 1.
DR SMART; SM00573; HSA; 1.
DR SMART; SM00717; SANT; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS51204; HSA; 1.
DR PROSITE; PS51294; HTH_MYB; 1.
DR PROSITE; PS50090; MYB_LIKE; 1.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Reference proteome {ECO:0000313|Proteomes:UP000001194}.
FT DOMAIN 495..593
FT /note="HSA"
FT /evidence="ECO:0000259|PROSITE:PS51204"
FT DOMAIN 893..948
FT /note="HTH myb-type"
FT /evidence="ECO:0000259|PROSITE:PS51294"
FT DOMAIN 893..944
FT /note="Myb-like"
FT /evidence="ECO:0000259|PROSITE:PS50090"
FT REGION 135..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 408..427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 576..610
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 656..712
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 980..1002
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1028..1050
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1084..1121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1148..1172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1207..1261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1290..1313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..156
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 157..171
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 656..709
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 980..995
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1100..1121
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1207..1222
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1235..1261
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1313 AA; 145399 MW; E0048D9C857D6C7A CRC64;
MTESSRAVLI KERVAQLHAI SARRNELLRQ MYHLIQQRNN VGALLPTEAQ EEDEPGLHKF
LQRFDLTRNG NASIANLTED EWSPIPLVVD QDSKAAIFIL PDLTSLTPQC ETTYDQFQTF
SPNLASYSVP PLGASPESKL PLSLESTLQV SSSKPQLAEE SEEDHDKSSI PILDESLGAP
TSVSPSSTSP AEIDAHKEKL PPVSPVTFKS TKEEAADIQD VTMEEDGVPV QLPSATSITQ
LSTTIQEPVE SMDVDEDHRD FHAAMNPEGN REDIREDEIT VVSGVRHSQA LELDATSEEV
LINSLSDSNY SEGNEDPELL STAVTHSLST LRPISLAPVL TRPPQRPIII ATPSAPPIND
QLFQLDMATL PELSMGQTSP PHPHYQSSTR YTLPPINVLP PEFVRKAKTL KQRKRDKERE
KTEGKKEKED LLPLGLNRWA ATLSANPVWK KVSRASKCLN SRDWAVAMTE LRLIRTLDRV
EFLKDGGRWS FRQPKKQRGV GGLAKTHWDY LMDEMKWMRI DFREERKWKM ALAYALSTAV
LEWHAMDSWE ERILCGVCVK WKSSYSSTEA FEDDGEAMDI DDTQPQKKSL VSVNYGSDDD
DDDEQDKDAQ SVVDPLEPAA MIEDALDTAS HLIDGVGENT VQPKMEDFDD LSALQNESET
TNESIQGMPT PSQSNVSTDV ATGLKSTSHN PVLGSKSSSQ SSSGDSDPVG SSVKAIKPIK
YGLLRENIAY ADDEKLFLNS NDVTQSSNEM PNYESAHSLD LDALFPDLQP LCLLDVTPAT
VGIEGKKKLG KNSDRDDPNK RIEETTYTKL YPTDKFMFAK PTLIGPLLPS KRWKDSTWLP
MEEMPVVPDS DGPMKIPDDS GNDLFDVRSS NGPAILAFQV AKDKGKRGVD HIWSASDDTL
LRSLSDKYPN NWALIAECFN GSRLTTPTDR RSASDCLERW KEKWGPEMRQ RPLEIVQAPL
EETVVPSTPS QMTTRGVKRL ASSSVSSQNA PIINSGSEPK KRRRHLLLQD SMRKAAKKRV
ELAQKMVAGQ RKTPAIHETH GQYSKMPKLT PAELSRMKAE KDARDVQDLA LARRRQEELA
RQNLLREQSQ RIGVPPVPAT QAPLSQQQPQ PQPQQQQQQQ QQLSQIQQSQ IQHLQQLQLM
HQATQAQRVN SAGSLSNARP GVGGSSRIST PSLATNNRLG LTAQQVMQLQ AIGGGSAILS
GHLPTNHQFT KRDATNSPSQ ASPPHGPVVP PSGVNSPRPE QTNHVQGPQV PGSGIARPTS
SLGNQYYPAT AAYIPDQVTV ALRLQMLQQQ QLLQQQQQAQ QQHQQAQGFP NSS
//
