ID   B0E746_ENTDS            Unreviewed;       793 AA.
AC   B0E746;
DT   26-FEB-2008, integrated into UniProtKB/TrEMBL.
DT   26-FEB-2008, sequence version 1.
DT   27-MAR-2024, entry version 49.
DE   SubName: Full=DNA replication helicase DNA2, putative {ECO:0000313|EMBL:EDR29657.1};
GN   ORFNames=EDI_060630 {ECO:0000313|EMBL:EDR29657.1};
OS   Entamoeba dispar (strain ATCC PRA-260 / SAW760).
OC   Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC   Entamoeba.
OX   NCBI_TaxID=370354 {ECO:0000313|Proteomes:UP000008076};
RN   [1] {ECO:0000313|Proteomes:UP000008076}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC PRA-260 / SAW760 {ECO:0000313|Proteomes:UP000008076};
RA   Lorenzi H., Inman J., Schobel S., Amedeo P., Caler E.;
RT   "Annotation of Entamoeba dispar SAW760.";
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DS547940; EDR29657.1; -; Genomic_DNA.
DR   RefSeq; XP_001734206.1; XM_001734154.1.
DR   AlphaFoldDB; B0E746; -.
DR   EnsemblProtists; EDR29657; EDR29657; EDI_060630.
DR   GeneID; 5879103; -.
DR   KEGG; edi:EDI_060630; -.
DR   VEuPathDB; AmoebaDB:EDI_060630; -.
DR   eggNOG; KOG1805; Eukaryota.
DR   OMA; DDLWYDT; -.
DR   OrthoDB; 22664at2759; -.
DR   Proteomes; UP000008076; Unassembled WGS sequence.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.90.320.10; -; 1.
DR   InterPro; IPR014808; DNA_replication_fac_Dna2_N.
DR   InterPro; IPR011604; PDDEXK-like_dom_sf.
DR   PANTHER; PTHR36531; CRISPR-ASSOCIATED EXONUCLEASE CAS4; 1.
DR   PANTHER; PTHR36531:SF6; DNA REPLICATION ATP-DEPENDENT HELICASE_NUCLEASE; 1.
DR   Pfam; PF08696; Dna2; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000313|EMBL:EDR29657.1};
KW   Helicase {ECO:0000313|EMBL:EDR29657.1};
KW   Hydrolase {ECO:0000313|EMBL:EDR29657.1};
KW   Nucleotide-binding {ECO:0000313|EMBL:EDR29657.1}.
FT   DOMAIN          38..236
FT                   /note="DNA replication factor Dna2 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08696"
SQ   SEQUENCE   793 AA;  92369 MW;  9EA0A92E6DF90770 CRC64;
     MLVRKKVSQK TWNLYIRCEV VALLDDEKKL KRYKVEEQQE KKQFILYLDD LWYDTSLKVG
     DFIHLIFLEE RTKNSLPNPF ILNNRTPILL IQNPDYLINT TSTVSSTWCN RQTVIKNYLF
     LDDYYEATTL GTIIHGTIQH ILITNPPEFN KIIFKSMIEE LSEEVLTKIY VLGITRKEFI
     DHAMEFYDTV NDWYQCWKTK TIKTNLNREI HFTEFIASEP QIQSQIFGFK GAIDILLNGS
     EGEIIVEMKT GKQKEENFGQ IAYYFLLLSG FLQKPHHQFR GLLNYVHRQN NDFVQVVPTI
     PQLVAITQLR NSLALYSKNM TIPNEEECIR KEVSCKYCQV TEHCSLICEN DGINYNKSVI
     QHLNSLEKAF YFKYLNDVRL EMKHIETENQ KRWLFPNEVK SIGRRMKLIK SEYTMKFPDY
     YIYTFEGECV YDESLICVST EDGKINIIKG YMLPFEDDDI ITKEKIIDCD QQKTNQSIIS
     EEQGIEQLQE VLLKRVKIKT PQRIISTLSL FRLDKFSGTN ALQVIMTTVG KLMRNDNDMK
     RIRDFVINSK PCPVINFNLD LSQTQNIDDI HNEEEDGDDL DWILDKLNIS EQTLIQKQIS
     EKDDFLLNSL SSSQEITPIT GLCSNMILST IATFCSKTQQ RVFVTASNQI LLNKLYDVLP
     KEKTLKLSAI DDLLHINPVI ETIINEHPIV LGSFRESSKK ITQTMPFDIA IIADAINVNV
     VQSLNVFYLT KTVWLFEGEK ISHLNETSQI ENQSIFSLMS RTSQYSMSTL LDKEYQLKQI
     IDIEDLGDID DFL
//