ID B0E9I9_ENTDS Unreviewed; 687 AA.
AC B0E9I9;
DT 26-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 26-FEB-2008, sequence version 1.
DT 24-JAN-2024, entry version 79.
DE SubName: Full=FYVE, RhoGEF and PH domain-containing protein, putative {ECO:0000313|EMBL:EDR28796.1};
DE EC=2.7.11.1 {ECO:0000313|EMBL:EDR28796.1};
GN ORFNames=EDI_130730 {ECO:0000313|EMBL:EDR28796.1};
OS Entamoeba dispar (strain ATCC PRA-260 / SAW760).
OC Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC Entamoeba.
OX NCBI_TaxID=370354 {ECO:0000313|Proteomes:UP000008076};
RN [1] {ECO:0000313|Proteomes:UP000008076}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC PRA-260 / SAW760 {ECO:0000313|Proteomes:UP000008076};
RA Lorenzi H., Inman J., Schobel S., Amedeo P., Caler E.;
RT "Annotation of Entamoeba dispar SAW760.";
RL Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; DS548367; EDR28796.1; -; Genomic_DNA.
DR RefSeq; XP_001735014.1; XM_001734962.1.
DR AlphaFoldDB; B0E9I9; -.
DR EnsemblProtists; EDR28796; EDR28796; EDI_130730.
DR GeneID; 5879946; -.
DR KEGG; edi:EDI_130730; -.
DR VEuPathDB; AmoebaDB:EDI_130730; -.
DR eggNOG; KOG4424; Eukaryota.
DR OMA; THNGRSR; -.
DR OrthoDB; 2916231at2759; -.
DR Proteomes; UP000008076; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR PANTHER; PTHR12673:SF263; GRFA PROTEIN, PUTATIVE-RELATED; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Transferase {ECO:0000313|EMBL:EDR28796.1}.
FT DOMAIN 52..236
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 613..647
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 622..637
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 687 AA; 80810 MW; EBA518EFD19093D0 CRC64;
MEVPELPPKP IQLIKLEQSK NNLKEIKEIF KENSISNYKV EDSIDNCCSL EKRKMVCKEI
YETEISYITS LGICENFYYR KMIKETSPFH AEDVKQIFLY YDEILRCNRE FASMVIKSWK
DKTFEDSIGE LFLNFSPFFI VYRNFLINHN KAFTLLTKLE EDTKLKRYLE NCQYQISTNQ
NLDLRDYLIM PVQRLPRYNL LLTDLLKNTP TNHCDYQNII KALEVMKEVT TKVNESISTN
KQQQKLFDLR SKLAKRNGFE VIEPHRILLS EETIIQFTHN GRSRRGLILF NDCILLTKKE
EKLMKIRFII ELSRCSIVEP NKEKSLQIYS NVKSCEIEFE SYEQKEHWKS ISKDAIIRMK
KTSDFVFSPL VISPEDVHEC KICQSEIKKR KKYYCKKCLN YICSKCWNSI GKCCLKCHSL
EKEKVSQKKI EPFKTEKECD FFNLNNNSNQ LSIQIQSSSL TPTKGLPELK KELKKVVGFV
GVLKEHQPKE NSALTENTSK GCRKEQSLQK GITPTERTFQ TEKDTRPVIR QIGLGKDTIT
LNENGYCFSP DTTKKEKVKL IEEQQDDRLI EGMDDKIEVV LGLRKKSNSM IQEEINLHER
FCKKKRRNFI SKSLETNEQK QNSFQKKSKK KDIVPQNSEE DSLSIETIPE GPGRVQFLKK
LNEKRIQQAK EEIKRYEIKP KLVNDKK
//