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Database: UniProt
Entry: B0E9I9_ENTDS
LinkDB: B0E9I9_ENTDS
Original site: B0E9I9_ENTDS 
ID   B0E9I9_ENTDS            Unreviewed;       687 AA.
AC   B0E9I9;
DT   26-FEB-2008, integrated into UniProtKB/TrEMBL.
DT   26-FEB-2008, sequence version 1.
DT   24-JAN-2024, entry version 79.
DE   SubName: Full=FYVE, RhoGEF and PH domain-containing protein, putative {ECO:0000313|EMBL:EDR28796.1};
DE            EC=2.7.11.1 {ECO:0000313|EMBL:EDR28796.1};
GN   ORFNames=EDI_130730 {ECO:0000313|EMBL:EDR28796.1};
OS   Entamoeba dispar (strain ATCC PRA-260 / SAW760).
OC   Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC   Entamoeba.
OX   NCBI_TaxID=370354 {ECO:0000313|Proteomes:UP000008076};
RN   [1] {ECO:0000313|Proteomes:UP000008076}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC PRA-260 / SAW760 {ECO:0000313|Proteomes:UP000008076};
RA   Lorenzi H., Inman J., Schobel S., Amedeo P., Caler E.;
RT   "Annotation of Entamoeba dispar SAW760.";
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; DS548367; EDR28796.1; -; Genomic_DNA.
DR   RefSeq; XP_001735014.1; XM_001734962.1.
DR   AlphaFoldDB; B0E9I9; -.
DR   EnsemblProtists; EDR28796; EDR28796; EDI_130730.
DR   GeneID; 5879946; -.
DR   KEGG; edi:EDI_130730; -.
DR   VEuPathDB; AmoebaDB:EDI_130730; -.
DR   eggNOG; KOG4424; Eukaryota.
DR   OMA; THNGRSR; -.
DR   OrthoDB; 2916231at2759; -.
DR   Proteomes; UP000008076; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR001331; GDS_CDC24_CS.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR   PANTHER; PTHR12673:SF263; GRFA PROTEIN, PUTATIVE-RELATED; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS00741; DH_1; 1.
DR   PROSITE; PS50010; DH_2; 1.
PE   4: Predicted;
KW   Transferase {ECO:0000313|EMBL:EDR28796.1}.
FT   DOMAIN          52..236
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   REGION          613..647
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        622..637
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   687 AA;  80810 MW;  EBA518EFD19093D0 CRC64;
     MEVPELPPKP IQLIKLEQSK NNLKEIKEIF KENSISNYKV EDSIDNCCSL EKRKMVCKEI
     YETEISYITS LGICENFYYR KMIKETSPFH AEDVKQIFLY YDEILRCNRE FASMVIKSWK
     DKTFEDSIGE LFLNFSPFFI VYRNFLINHN KAFTLLTKLE EDTKLKRYLE NCQYQISTNQ
     NLDLRDYLIM PVQRLPRYNL LLTDLLKNTP TNHCDYQNII KALEVMKEVT TKVNESISTN
     KQQQKLFDLR SKLAKRNGFE VIEPHRILLS EETIIQFTHN GRSRRGLILF NDCILLTKKE
     EKLMKIRFII ELSRCSIVEP NKEKSLQIYS NVKSCEIEFE SYEQKEHWKS ISKDAIIRMK
     KTSDFVFSPL VISPEDVHEC KICQSEIKKR KKYYCKKCLN YICSKCWNSI GKCCLKCHSL
     EKEKVSQKKI EPFKTEKECD FFNLNNNSNQ LSIQIQSSSL TPTKGLPELK KELKKVVGFV
     GVLKEHQPKE NSALTENTSK GCRKEQSLQK GITPTERTFQ TEKDTRPVIR QIGLGKDTIT
     LNENGYCFSP DTTKKEKVKL IEEQQDDRLI EGMDDKIEVV LGLRKKSNSM IQEEINLHER
     FCKKKRRNFI SKSLETNEQK QNSFQKKSKK KDIVPQNSEE DSLSIETIPE GPGRVQFLKK
     LNEKRIQQAK EEIKRYEIKP KLVNDKK
//
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