ID B0EC51_ENTDS Unreviewed; 819 AA.
AC B0EC51;
DT 26-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 26-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=GPI ethanolamine phosphate transferase 3 {ECO:0000256|ARBA:ARBA00020841};
GN ORFNames=EDI_125350 {ECO:0000313|EMBL:EDR27899.1};
OS Entamoeba dispar (strain ATCC PRA-260 / SAW760).
OC Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC Entamoeba.
OX NCBI_TaxID=370354 {ECO:0000313|Proteomes:UP000008076};
RN [1] {ECO:0000313|Proteomes:UP000008076}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC PRA-260 / SAW760 {ECO:0000313|Proteomes:UP000008076};
RA Lorenzi H., Inman J., Schobel S., Amedeo P., Caler E.;
RT "Annotation of Entamoeba dispar SAW760.";
RL Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC biosynthesis. {ECO:0000256|ARBA:ARBA00004687}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.
CC {ECO:0000256|ARBA:ARBA00008695}.
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DR EMBL; DS548673; EDR27899.1; -; Genomic_DNA.
DR RefSeq; XP_001733314.1; XM_001733262.1.
DR EnsemblProtists; EDR27899; EDR27899; EDI_125350.
DR GeneID; 5880858; -.
DR KEGG; edi:EDI_125350; -.
DR eggNOG; KOG2126; Eukaryota.
DR OrthoDB; 5479199at2759; -.
DR UniPathway; UPA00196; -.
DR Proteomes; UP000008076; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0051377; F:mannose-ethanolamine phosphotransferase activity; IEA:InterPro.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd16023; GPI_EPT_3; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR002591; Phosphodiest/P_Trfase.
DR InterPro; IPR037675; PIG-O_N.
DR InterPro; IPR039524; PIGO/GPI13.
DR PANTHER; PTHR23071:SF1; GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3; 1.
DR PANTHER; PTHR23071; PHOSPHATIDYLINOSITOL GLYCAN; 1.
DR Pfam; PF01663; Phosphodiest; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW GPI-anchor biosynthesis {ECO:0000256|ARBA:ARBA00022502};
KW Isomerase {ECO:0000313|EMBL:EDR27899.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EDR27899.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 396..418
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 430..448
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 460..476
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 488..509
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 521..539
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 551..572
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 578..602
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 609..630
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 650..669
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 681..700
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 720..743
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 755..775
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 795..812
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 819 AA; 94037 MW; 7F92AC97E7AE1687 CRC64;
MISLRKEYIY FIVFVIVLKL SAIYLYGSGF XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
XXXXFHSLEN QYPSRSSKYH FIPDPPTTTA QRVKAMTTGG VPAFIEISNM FNNPVILEDS
LIHQFKENGL RTVFEGDSLW VDLYPNQFNN VSTGPSLDIA DLDSVDNICD KALQQHQNAS
DYDIMISHFL GIDHTGHYYV TNHPSMKKKL IEINNILNRS LYSLPEDTLA LVFGDHGLTE
EGNHGGSTLE EIDAGLFVYD NRKNRKGGRK EVEKITQVDI VPTIAIGMGI PIPYSNIGTP
IRDIILGREE EIEDIQRYVN ALNITTNQII RYLKEKEGIR REEWIKEIEK EIKKIQEEEI
KYFEQKEKLI EVMNEHERIS HEIHKKYVKH KSTFKFNYML AGIILMILSL LCGLFFVFGY
PQFHFTTLKI IHGFVLGMVP ALFLRRIYDI GMSKFDQYVF FTSLLGGLSF ISNFASQFNT
FILSGTRITT TVTFDIVFNL VLCFIYGFGQ YTDSYIKEEE YTSFYVAEWL SIVMFFFALS
QRKQGSTKIL CLHFLLIILS SCIKLFSFHV ISLLVLPIVL YIFTHSINIS ISSICAFVYH
LIRPYPTSLL GIILPDTIYL LTLISLIICY KQRLSVIHYL YSLIPMATVI LPYSSSTILL
LFIGFVYVFK EYEFSESITT FFLFIGIHFF FLSGHAFQFS DIQFNAGFIG IPFYSFFGNG
FLVILNTFFF PSIAVLAIAG IIQSKVNGTL LYTRSSILVM LFFGYQLLSI MIFTYFVSGH
LEIFRLFTPK VCFDAAITVV VDVVVFVVYF IIRESKNNH
//
