ID   B0EDI1_ENTDS            Unreviewed;       292 AA.
AC   B0EDI1;
DT   26-FEB-2008, integrated into UniProtKB/TrEMBL.
DT   26-FEB-2008, sequence version 1.
DT   27-MAR-2024, entry version 63.
DE   SubName: Full=DNA-damage inducible protein ddi1, putative {ECO:0000313|EMBL:EDR27407.1};
DE            EC=3.4.23.16 {ECO:0000313|EMBL:EDR27407.1};
GN   ORFNames=EDI_337130 {ECO:0000313|EMBL:EDR27407.1};
OS   Entamoeba dispar (strain ATCC PRA-260 / SAW760).
OC   Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC   Entamoeba.
OX   NCBI_TaxID=370354 {ECO:0000313|Proteomes:UP000008076};
RN   [1] {ECO:0000313|Proteomes:UP000008076}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC PRA-260 / SAW760 {ECO:0000313|Proteomes:UP000008076};
RA   Lorenzi H., Inman J., Schobel S., Amedeo P., Caler E.;
RT   "Annotation of Entamoeba dispar SAW760.";
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the DDI1 family.
CC       {ECO:0000256|ARBA:ARBA00009136}.
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DR   EMBL; DS548801; EDR27407.1; -; Genomic_DNA.
DR   RefSeq; XP_001736344.1; XM_001736292.1.
DR   AlphaFoldDB; B0EDI1; -.
DR   EnsemblProtists; EDR27407; EDR27407; EDI_337130.
DR   GeneID; 5881341; -.
DR   KEGG; edi:EDI_337130; -.
DR   eggNOG; KOG0012; Eukaryota.
DR   OMA; QTIGVIH; -.
DR   OrthoDB; 25667at2759; -.
DR   Proteomes; UP000008076; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 2.40.70.10; Acid Proteases; 1.
DR   InterPro; IPR019103; Peptidase_aspartic_DDI1-type.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   PANTHER; PTHR12917; ASPARTYL PROTEASE DDI-RELATED; 1.
DR   PANTHER; PTHR12917:SF1; AT13091P; 1.
DR   Pfam; PF09668; Asp_protease; 1.
DR   SUPFAM; SSF50630; Acid proteases; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000313|EMBL:EDR27407.1};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        7..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        34..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          75..193
FT                   /note="Aspartic peptidase DDI1-type"
FT                   /evidence="ECO:0000259|Pfam:PF09668"
SQ   SEQUENCE   292 AA;  33624 MW;  FEBFF6BEF4F77A87 CRC64;
     MFFISYLCYL YYLSVHSILY SYSYSLLIPF SIPFLLYILL LLYHLFICSL ISIYYKKQRM
     DIVKEQQKIE ERIRQEEIDR QIKVLENEHP ELLVKGDLVF VKVKINGVVK EAMIDCGAQE
     TVISIKACKD YYRVKKMYQG VGRTQTIGVI HLVPIIIGNT YCITTLNVLG DDSPLDHLLI
     GTNTLKSIGA VIDFSESVLR IKDDKIKFMS NTDVDYILQK PFHIRQIHGD SSFKKTNPIF
     KPTLPNFENA CLPRYPIPLI EQVMVGGKSE EEASEILDKS GGDITFNQIK LY
//