ID   B0EM47_ENTDS            Unreviewed;       346 AA.
AC   B0EM47;
DT   26-FEB-2008, integrated into UniProtKB/TrEMBL.
DT   26-FEB-2008, sequence version 1.
DT   22-FEB-2023, entry version 42.
DE   SubName: Full=Rho/RAC guanine nucleotide exchange factor, putative {ECO:0000313|EMBL:EDR24398.1};
DE            EC=2.7.11.1 {ECO:0000313|EMBL:EDR24398.1};
DE   Flags: Fragment;
GN   ORFNames=EDI_286080 {ECO:0000313|EMBL:EDR24398.1};
OS   Entamoeba dispar (strain ATCC PRA-260 / SAW760).
OC   Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC   Entamoeba.
OX   NCBI_TaxID=370354 {ECO:0000313|Proteomes:UP000008076};
RN   [1] {ECO:0000313|Proteomes:UP000008076}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC PRA-260 / SAW760 {ECO:0000313|Proteomes:UP000008076};
RA   Lorenzi H., Inman J., Schobel S., Amedeo P., Caler E.;
RT   "Annotation of Entamoeba dispar SAW760.";
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; DS549961; EDR24398.1; -; Genomic_DNA.
DR   RefSeq; XP_001739227.1; XM_001739175.1.
DR   AlphaFoldDB; B0EM47; -.
DR   EnsemblProtists; EDR24398; EDR24398; EDI_286080.
DR   GeneID; 5884357; -.
DR   KEGG; edi:EDI_286080; -.
DR   VEuPathDB; AmoebaDB:EDI_286080; -.
DR   eggNOG; KOG3522; Eukaryota.
DR   OrthoDB; 2916834at2759; -.
DR   Proteomes; UP000008076; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR   PANTHER; PTHR12673:SF263; GRFA PROTEIN, PUTATIVE-RELATED; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   PROSITE; PS50010; DH_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Transferase {ECO:0000313|EMBL:EDR24398.1}.
FT   DOMAIN          133..313
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   COILED          296..323
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   NON_TER         346
FT                   /evidence="ECO:0000313|EMBL:EDR24398.1"
SQ   SEQUENCE   346 AA;  40613 MW;  EE9205EF6A544FC8 CRC64;
     MKQKEEIQQS TTLSKSASAL DIKMDNANDY LRSRGKTLIN VEQVEPKIQH HRIDGSDQII
     ENTNKLKDNE NQIKTSTLDD SINREEIKGK DNIKLVDLDI SFNIPKFKFI CNGTLCNEDQ
     AKMIADLNLK KAKRKHIIME LLETEKSYVN RMKECLDTFY IPLKKYMKEE DLKIAFNCLP
     NIYKINVKLI QELNERKNNT SDLGVMKVAD ILNSFFTLNE VEQYYGEYII TGDSAVTYPF
     EIHGEEIKTL LSKWVDECKI PSNYLIEPVQ RFPRYILLLE SLIKATPTFT NEYIELQKVN
     EHIKEITKRI DEKKNNYISH QKQNYYKSYL PHPINFGTFI YEGSYY
//