ID B0ENT2_ENTDS Unreviewed; 1189 AA.
AC B0ENT2;
DT 26-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 26-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=ATP-dependent RNA helicase, putative {ECO:0000313|EMBL:EDR23819.1};
DE EC=3.4.22.44 {ECO:0000313|EMBL:EDR23819.1};
GN ORFNames=EDI_058380 {ECO:0000313|EMBL:EDR23819.1};
OS Entamoeba dispar (strain ATCC PRA-260 / SAW760).
OC Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC Entamoeba.
OX NCBI_TaxID=370354 {ECO:0000313|Proteomes:UP000008076};
RN [1] {ECO:0000313|Proteomes:UP000008076}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC PRA-260 / SAW760 {ECO:0000313|Proteomes:UP000008076};
RA Lorenzi H., Inman J., Schobel S., Amedeo P., Caler E.;
RT "Annotation of Entamoeba dispar SAW760.";
RL Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; DS550136; EDR23819.1; -; Genomic_DNA.
DR RefSeq; XP_001739796.1; XM_001739744.1.
DR AlphaFoldDB; B0ENT2; -.
DR EnsemblProtists; EDR23819; EDR23819; EDI_058380.
DR GeneID; 5884936; -.
DR KEGG; edi:EDI_058380; -.
DR VEuPathDB; AmoebaDB:EDI_058380; -.
DR eggNOG; KOG0920; Eukaryota.
DR OMA; GIWKIVL; -.
DR OrthoDB; 53793at2759; -.
DR Proteomes; UP000008076; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd17917; DEXHc_RHA-like; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF145; ATP-DEPENDENT RNA HELICASE DHX29; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Helicase {ECO:0000313|EMBL:EDR23819.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:EDR23819.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 448..611
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 688..859
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 131..174
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 209..236
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1151..1178
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 14..29
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1189 AA; 136845 MW; 7A12F9B52EE2E5AF CRC64;
MAKALERQRL EKIQRLQQNQ STPSTQPKIE ISKPKIEPKL VIQQKKEKKE QKIIEKKEIE
KQQSDVQNVQ RLKVLYDSLI NDFSLTPELI KKGMVGATLE NSDDITVDMV IEWLCLNIPS
RLLPNSLGGT LNKVKSEKQE IKQEIKQEIK KEIIKTQEIQ EKQKEQEIEE EEDIDALLDR
KAFKEAMDST TKKKKKTPEE MRAEGLKRKA EIARLREEAE KRKKEEVQED EEENELNFNF
DGEIKEEENE RWNIISAAED TKWTGKFPSV IICDYCRRQK YDNPKYKDEK CKEGYLMSAS
VQLNDKSKTV LHARIPEENT AFLEKATAKN YIALRLLFEM KVQRNFINNF SPRYQEVFDN
WTNNSPEEIT KNSIILLVNQ TPKGEKKKEK EIEQPSINKF TSEIQAKDKF SDDYYFNEMN
KEINSSHYQD MLEGRKQLPI YSNKDHFINL LNNNQIVVVS GTTGSGKSTQ LPQFVLESEL
LNKRGSQTKI YVTQPRRISA VGLSSRVIDE RGSNKFVGHQ IRFEKTGDEK LVYCTVGVML
RKVLGNPDLE GISHLFIDEV HERDINTDFL LLLIKKLITR NKTIKIIIMS ATLAVELFEQ
YFGSASCLRI ESKIHPVQTF YLDDVISFTN YSIDSSSEYY NYKYDDLQKK LIGDQLITVD
MNKVNNKSSK TVSDMINQST VNYELIMDLL HYLITNKPIG CILVFLPGIY EITSLQKEII
STPPFNNLNK FKIHILHSSV PLQQQKEAFS IAPNGIWKIV LSTNIAETSI TIPDAKYLID
TGLVRIMSYD RSTKMQRLIL TKISKANAQQ RTGRVGRVSA GECYKMYSQK RENSFETYPQ
PEIKRLPLES LCLQILLFGE KNPVQFLADA LDAPSQTQIE KSLLQLVTIK AAKRISHLDI
SGAVKEFEYS ATPLGSALAA LPVEVSIGKM LLLGCAFGIA QEATLLAACM SVQPLVNGEN
GSIIKRRYCS DASDHIATMK IVEHYIELER KGNGIQFCKN NNINIIIVKE ILDTRKQFIE
LLKNYNYPIQ SIQSSYKKEL LLFILTYVFY PNIIIPQQII GKTSIEYEYY TKKHQVFMGV
SSINSMPRID FKENVFIYTN MVKSNKIMVW ECSLIKKVFI ALIATSVVVN YKQKTITLDG
WITINSTPLF IAQLVQMRKE LKDALDDVIN QKTQLSKEFM NHLIETKLN
//
