ID B0EQA4_ENTDS Unreviewed; 389 AA.
AC B0EQA4;
DT 26-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 26-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Phosphatidylinositol 3-kinase catalytic subunit gamma, putative {ECO:0000313|EMBL:EDR23287.1};
DE EC=2.7.1.153 {ECO:0000313|EMBL:EDR23287.1};
GN ORFNames=EDI_352950 {ECO:0000313|EMBL:EDR23287.1};
OS Entamoeba dispar (strain ATCC PRA-260 / SAW760).
OC Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC Entamoeba.
OX NCBI_TaxID=370354 {ECO:0000313|Proteomes:UP000008076};
RN [1] {ECO:0000313|Proteomes:UP000008076}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC PRA-260 / SAW760 {ECO:0000313|Proteomes:UP000008076};
RA Lorenzi H., Inman J., Schobel S., Amedeo P., Caler E.;
RT "Annotation of Entamoeba dispar SAW760.";
RL Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. {ECO:0000256|PROSITE-
CC ProRule:PRU00880}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS550358; EDR23287.1; -; Genomic_DNA.
DR RefSeq; XP_001740300.1; XM_001740248.1.
DR AlphaFoldDB; B0EQA4; -.
DR EnsemblProtists; EDR23287; EDR23287; EDI_352950.
DR GeneID; 5885470; -.
DR KEGG; edi:EDI_352950; -.
DR eggNOG; KOG0904; Eukaryota.
DR OrthoDB; 22619at2759; -.
DR Proteomes; UP000008076; Unassembled WGS sequence.
DR GO; GO:0046934; F:1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR002420; PI3K-type_C2_dom.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF14; LD28067P; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR SMART; SM00145; PI3Ka; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51547; C2_PI3K; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|EMBL:EDR23287.1};
KW Transferase {ECO:0000313|EMBL:EDR23287.1}.
FT DOMAIN 1..85
FT /note="C2 PI3K-type"
FT /evidence="ECO:0000259|PROSITE:PS51547"
FT DOMAIN 96..279
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 342..389
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
SQ SEQUENCE 389 AA; 45055 MW; 2D4967053B92BF04 CRC64;
MFCSCGMDLS PNSISSENNT TTIIGWTDIY LFDYRKLMIS GNYSQAIMLP PVIPIGIPVT
EFGNLNQLNG KIQFKLPTGP TIQFDNSTVD ITKELNEKCE LNEEEQKKIN TLIVTTNLLK
EIEKEDKELI WRGRQFILNE ETLHLHPSSI VLLCQSVPWD KPKEVKVFEQ LIQKWPKVSH
IIALRLLHFS FANSFIRQYA VNCLVECNDE HLSTIMMQLI QSLKFEATPL SDLAIFLIHR
ALNKRSTIGR IFFWLIKSEL HIPETQRRFA LLLEAFLMVC GAQRTVIKNQ LDLCKKLTSL
YTQQNQTWKN DINQLTKELN NIILPQITYV PFKSSLKFTK IVAENCKVLD SLRKPLFLTF
KNEDPEGDPI YIIFKKDDDL RQDMTSCSY
//