ID   B0EUK4_ENTDS            Unreviewed;       633 AA.
AC   B0EUK4;
DT   26-FEB-2008, integrated into UniProtKB/TrEMBL.
DT   26-FEB-2008, sequence version 1.
DT   27-MAR-2024, entry version 58.
DE   SubName: Full=Rho/RAC guanine nucleotide exchange factor, putative {ECO:0000313|EMBL:EDR21780.1};
DE            EC=2.7.11.1 {ECO:0000313|EMBL:EDR21780.1};
GN   ORFNames=EDI_334490 {ECO:0000313|EMBL:EDR21780.1};
OS   Entamoeba dispar (strain ATCC PRA-260 / SAW760).
OC   Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC   Entamoeba.
OX   NCBI_TaxID=370354 {ECO:0000313|Proteomes:UP000008076};
RN   [1] {ECO:0000313|Proteomes:UP000008076}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC PRA-260 / SAW760 {ECO:0000313|Proteomes:UP000008076};
RA   Lorenzi H., Inman J., Schobel S., Amedeo P., Caler E.;
RT   "Annotation of Entamoeba dispar SAW760.";
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; DS550903; EDR21780.1; -; Genomic_DNA.
DR   RefSeq; XP_001741742.1; XM_001741690.1.
DR   AlphaFoldDB; B0EUK4; -.
DR   EnsemblProtists; EDR21780; EDR21780; EDI_334490.
DR   GeneID; 5886682; -.
DR   KEGG; edi:EDI_334490; -.
DR   VEuPathDB; AmoebaDB:EDI_334490; -.
DR   eggNOG; KOG4305; Eukaryota.
DR   OMA; IMIMDID; -.
DR   OrthoDB; 20723at2759; -.
DR   Proteomes; UP000008076; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR   PANTHER; PTHR12673:SF263; GRFA PROTEIN, PUTATIVE-RELATED; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   PROSITE; PS50010; DH_2; 1.
PE   4: Predicted;
KW   Transferase {ECO:0000313|EMBL:EDR21780.1}.
FT   DOMAIN          293..486
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
SQ   SEQUENCE   633 AA;  73808 MW;  CBF84FB5B39676AB CRC64;
     MINTFAKRWV TESTSNDIEY ALFSINNHII EVPKEYLYND RARTTIMQTI VKYNETDINN
     GKVISLRGGR TEEKEFRTYL RYLRGSVFCE KKLTVKKMAR TISILLQFGV GINSSVKLLG
     LNEETCEEII AYFLAMLNTK TLNLIMIMDI DRSWKNLLEN AFGTLSFYYG EAMLSNIQVL
     EGLGRFYDNL DLVHAYLSEM SQKEMNPKQL IDIDQVFCPS KENISETKII LGGGRHFDEG
     FERRKSNLAG SIPKKASKIT TFIGDDLKKF IIVQLGIESW LVRSMFVFKK MKTRQMVIEE
     WKTTEFNLCE NMKLLKEYFK DPMQQLIIDK TIDGFGNKEY NTLFSTLNEC IDCSQQMVNE
     MNKVLTPQNM KCDFTFGKYA DQWVVLARYL LPYTTDYNYA KAIFDKIKQT EEGKQFIDDC
     QQNIFIKKNT RPSFEDLLIQ PVQRLMRYPL LLKEIIKNTG PRHPDQPFLK TAFTHFNYFS
     NLVNELGKKR DELKYVSQLL GDENIFVNNR YMYSEAMVTY KKKHCYAFLF SDELVFAKEQ
     AVQENKPLLA ANKATKKVKI EALICINDKT EVMLSSNVLN IKIDDVSCLL SFDSIEKCKE
     WSQTISKNIT YGWWDLNRSD CWVAQMRDAD SVE
//