GenomeNet

Database: UniProt
Entry: B0EVP7_DANRE
LinkDB: B0EVP7_DANRE
Original site: B0EVP7_DANRE 
ID   B0EVP7_DANRE            Unreviewed;       528 AA.
AC   B0EVP7;
DT   26-FEB-2008, integrated into UniProtKB/TrEMBL.
DT   26-FEB-2008, sequence version 1.
DT   08-JUN-2016, entry version 68.
DE   SubName: Full=Suppressor of cytokine signaling 5 {ECO:0000313|EMBL:ABM68036.1};
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSDARP00000137510};
GN   Name=socs5a {ECO:0000313|Ensembl:ENSDARP00000137510,
GN   ECO:0000313|ZFIN:ZDB-GENE-061013-408};
GN   Synonyms=SOCS5 {ECO:0000313|EMBL:ABM68036.1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|EMBL:ABM68036.1};
RN   [1] {ECO:0000313|EMBL:ABM68036.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Jin H., Shao J.;
RT   "Evolution of the suppressor of cytokine signaling (SOCS) family.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000137510, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000137510,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
RN   [3] {ECO:0000313|Ensembl:ENSDARP00000137510}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000137510};
RG   Ensembl;
RL   Submitted (NOV-2015) to UniProtKB.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|SAAS:SAAS00258121}.
CC   -!- SIMILARITY: Contains SOCS box domain.
CC       {ECO:0000256|SAAS:SAAS00517535}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CR385067; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; EF195763; ABM68036.1; -; mRNA.
DR   RefSeq; NP_001107230.1; NM_001113758.1.
DR   UniGene; Dr.117259; -.
DR   ProteinModelPortal; B0EVP7; -.
DR   SMR; B0EVP7; 361-516.
DR   STRING; 7955.ENSDARP00000102564; -.
DR   PaxDb; B0EVP7; -.
DR   Ensembl; ENSDART00000159167; ENSDARP00000137510; ENSDARG00000100717.
DR   GeneID; 768142; -.
DR   CTD; 768142; -.
DR   ZFIN; ZDB-GENE-061013-408; socs5a.
DR   eggNOG; KOG4566; Eukaryota.
DR   eggNOG; ENOG4111V4J; LUCA.
DR   GeneTree; ENSGT00760000119136; -.
DR   HOGENOM; HOG000027791; -.
DR   HOVERGEN; HBG054138; -.
DR   OMA; IQITELM; -.
DR   PhylomeDB; B0EVP7; -.
DR   Proteomes; UP000000437; Chromosome 12.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0007259; P:JAK-STAT cascade; IEA:InterPro.
DR   GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.30.505.10; -; 1.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR022252; SOCS4/SOCS5_dom.
DR   InterPro; IPR028420; SOCS5.
DR   InterPro; IPR001496; SOCS_box.
DR   PANTHER; PTHR24369:SF71; PTHR24369:SF71; 2.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF12610; SOCS; 1.
DR   Pfam; PF07525; SOCS_box; 1.
DR   SMART; SM00252; SH2; 1.
DR   SMART; SM00253; SOCS; 1.
DR   SMART; SM00969; SOCS_box; 1.
DR   SUPFAM; SSF158235; SSF158235; 1.
DR   SUPFAM; SSF55550; SSF55550; 1.
DR   PROSITE; PS50001; SH2; 1.
DR   PROSITE; PS50225; SOCS; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT   DOMAIN      373    468       SH2. {ECO:0000259|PROSITE:PS50001}.
FT   DOMAIN      463    512       SOCS box. {ECO:0000259|PROSITE:PS50225}.
SQ   SEQUENCE   528 AA;  58617 MW;  97AE0573FB70880C CRC64;
     MEKVGKVWSN LKRGCQSLLH TDGGSRVETS PQHQPQTDTV CHSVDGAQGD ITLDANSPSS
     SVAALPLVAW RTSGSVTRRG HNCVADVPQI LEITVEQDAD DARAPLGARR DSYSRHAPWS
     GKKRHSCSTK AQSSLETTDR RSGRSRRRHG TSNSPEELES GTTRSIRQQI HDTVGLCLPL
     RSSSRNTHLP PPKRKIQITE LMLETCPFAP GSDLARKWHL IKQHTAPINV IPLDSSPDAC
     GATCASPEDE EERLRERRRL SIEEGVDPPP DAQIHTVEAI TAPLASLYKL GPKLAPGMGE
     AVGDSRGAAA ANCDSEDDET TTLCLQARKP KQWQASGEGH PSSKQPGPWK VHTQIDYIHC
     LVPDLLQITA LPCYWGVMDR YEAEALLDGR PEGTFLLRDS AQEDYLFSVS FRRYGRSLHA
     RIEQWNHNFS FDAHDPCVFH AATVTALLEH YKDPSACMFF EPLLTVPLHR TFPFGLQSLA
     RAAICHGITY DGIGALPLPP ALQDYLREYH YKQRVRVRWL EREPVKAK
//
DBGET integrated database retrieval system