ID   B0FNB0_MACMU            Unreviewed;      1199 AA.
AC   B0FNB0;
DT   26-FEB-2008, integrated into UniProtKB/TrEMBL.
DT   26-FEB-2008, sequence version 1.
DT   22-FEB-2023, entry version 73.
DE   SubName: Full=NLR family pyrin domain-containing protein 5 {ECO:0000313|EMBL:ABY67443.1};
GN   Name=NLRP5 {ECO:0000313|EMBL:ABY67443.1};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544 {ECO:0000313|EMBL:ABY67443.1};
RN   [1] {ECO:0000313|EMBL:ABY67443.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=18509866; DOI=10.1002/mrd.20937;
RA   McDaniel P., Wu X.;
RT   "Identification of oocyte-selective NLRP genes in rhesus macaque monkeys
RT   (Macaca mulatta).";
RL   Mol. Reprod. Dev. 76:151-159(2009).
CC   -!- SIMILARITY: Belongs to the NLRP family.
CC       {ECO:0000256|ARBA:ARBA00008665}.
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DR   EMBL; EU340329; ABY67443.1; -; mRNA.
DR   RefSeq; NP_001121103.1; NM_001127631.1.
DR   AlphaFoldDB; B0FNB0; -.
DR   GeneID; 704276; -.
DR   KEGG; mcc:704276; -.
DR   CTD; 126206; -.
DR   HOGENOM; CLU_002274_4_6_1; -.
DR   OrthoDB; 55870at2759; -.
DR   CDD; cd08320; Pyrin_NALPs; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   InterPro; IPR004020; DAPIN.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   InterPro; IPR041267; NLRP_HD2.
DR   InterPro; IPR041075; NOD2_WH.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR   PANTHER; PTHR45690:SF7; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 5; 1.
DR   Pfam; PF13516; LRR_6; 5.
DR   Pfam; PF05729; NACHT; 1.
DR   Pfam; PF17776; NLRC4_HD2; 1.
DR   Pfam; PF17779; NOD2_WH; 1.
DR   Pfam; PF02758; PYRIN; 1.
DR   SMART; SM00368; LRR_RI; 10.
DR   SMART; SM01289; PYRIN; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF52047; RNI-like; 1.
DR   PROSITE; PS50824; DAPIN; 1.
DR   PROSITE; PS50837; NACHT; 1.
PE   2: Evidence at transcript level;
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614}.
FT   DOMAIN          69..148
FT                   /note="Pyrin"
FT                   /evidence="ECO:0000259|PROSITE:PS50824"
FT   DOMAIN          279..409
FT                   /note="NACHT"
FT                   /evidence="ECO:0000259|PROSITE:PS50837"
FT   REGION          141..206
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        174..206
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1199 AA;  134183 MW;  D6ECD3ED7CD5B875 CRC64;
     MKVAEGLELG AVALLSASPR ALVTLSTGPT CSMLPKNPLF PQNLSSQPCL KMEGDKSLTF
     SSYGLQWCLH ELDKEEFQTF KELLKKKSSE STTCSIPQFE IENANVECLA LLLHEYYGAS
     LAWATSISIF ESMNLPTLSE KARDDMKRHS PEDLEPTTTG QGPSKEEVPG ISQAKRQESA
     TAAETKEQEI SQAMEQEGAT AAETEAQEIS QAMEQEGATA AETEAQECGG DKWDYKSHVV
     TKFAVKEDVR RGFEKTADWP EMQMLAGAFN SDQWGFRPHT VVLHGKSGIG KSALARRIVL
     CWAQGGLYQG MFSYVFFLPV REMQQQKESS VAEFISREWP DAQAPVTEIM SRPERLLFII
     DGFDDLGSVL NSDTKLCKDW AEKQPPFILI QSLLRKVLLP ESFLMVTVRD VGIEKLKSEV
     VSPRYLFVRG ITAEQRIHLL LERGIGEHQK MQGLRAIMNN RKLFDQCQVP AVGSLICVAL
     QLQDVVGESI APFGQTLTGL YAAFVFHQLT PRGVARRCLN LEERVVLKRF CRMAVEGVWN
     MKSVFDGDDL MVHGLGESEL RTLFHMNILL RDSHCKEFYT FFHLSLQDFC AALYYVLEGL
     EIEPALCPLF VEKTKRSMEL QQAGFHIHLL WMKRFLFGLV SEDVRRPLEV LLGCPVPLGV
     KQKLLHWVSL LGQQPNAAAP GDTLDAFRCL FETQDKEFVR SALNGFQEVW LPINQNLDLI
     ASSFCLQHGP YLRKIRVDVK GIFPRDELAE AWPVVPQWMR GKTLMEDQWE DFCSVLSTHP
     NLRQLDLGSS ILTERAMKTL CAKLRHPTCK IQTLKFRNAQ IASGLQHLWR TLIANRNLRS
     LNLGGTHLKE EDVRMACEAL KHPKCLLESL RLDRCGLTHA CYLKISQILT TSPSLKSLSL
     AGNEVTDQGV TPLSDALRVS QCALQKLTLE DCGIMATGCQ SLASALVSNR SLTHLCLSNN
     DLGNEGVNLL CRSMRLPHCS LRRLMLNRCN LHTAGCGFLA LALMGNAWLT HLSLSVNPVE
     DNGMKLLCEV MREPSCHLQD LELVKCHLTA ACCESLSCVI SRSRHLKSLD LTDNALGDGG
     VAALCEGLKQ KKSVLTRLGL KACGLTSDCC EALSLALSCN RHLTSLNLVQ NNFSPEGMMK
     LCSAFACPTS NLQIIGLWKW QYPVQIKKLL EEVQLLKPQI VIDGSWHSFD EDDRYWWKN
//