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Database: UniProt
Entry: B0I425_9HIV1
LinkDB: B0I425_9HIV1
Original site: B0I425_9HIV1 
ID   B0I425_9HIV1            Unreviewed;       335 AA.
AC   B0I425;
DT   18-MAR-2008, integrated into UniProtKB/TrEMBL.
DT   18-MAR-2008, sequence version 1.
DT   24-JAN-2024, entry version 85.
DE   SubName: Full=Pol protein {ECO:0000313|EMBL:BAF99394.1};
DE   Flags: Fragment;
GN   Name=pol {ECO:0000313|EMBL:BAF99394.1};
OS   Human immunodeficiency virus 1.
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11676 {ECO:0000313|EMBL:BAF99394.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1] {ECO:0000313|EMBL:BAF99394.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=18275342; DOI=10.1089/aid.2007.0129;
RA   Ibe S., Hattori J., Fujisaki S., Shigemi U., Fujisaki S., Shimizu K.,
RA   Nakamura K., Kazumi T., Yokomaku Y., Mamiya N., Hamaguchi M., Kaneda T.;
RT   "Trend of drug-resistant HIV type 1 emergence among therapy-naive patients
RT   in Nagoya, Japan: an 8-year surveillance from 1999 to 2006.";
RL   AIDS Res. Hum. Retroviruses 24:7-14(2008).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00000077};
CC   -!- SIMILARITY: Belongs to the retroviral Pol polyprotein family.
CC       {ECO:0000256|RuleBase:RU004064}.
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DR   EMBL; AB356234; BAF99394.1; -; Genomic_RNA.
DR   MEROPS; A02.001; -.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW.
DR   CDD; cd05482; HIV_retropepsin_like; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 2.40.70.10; Acid Proteases; 1.
DR   Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR   InterPro; IPR001969; Aspartic_peptidase_AS.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR001995; Peptidase_A2_cat.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   InterPro; IPR034170; Retropepsin-like_cat_dom.
DR   InterPro; IPR018061; Retropepsins.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR000477; RT_dom.
DR   PANTHER; PTHR33064; POL PROTEIN; 1.
DR   PANTHER; PTHR33064:SF35; RIBONUCLEASE H; 1.
DR   Pfam; PF00077; RVP; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF50630; Acid proteases; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   PROSITE; PS50175; ASP_PROT_RETROV; 1.
DR   PROSITE; PS00141; ASP_PROTEASE; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   3: Inferred from homology;
KW   Aspartyl protease {ECO:0000256|ARBA:ARBA00022750,
KW   ECO:0000256|RuleBase:RU004064};
KW   DNA integration {ECO:0000256|ARBA:ARBA00023195};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU004064};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022771};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   Protease {ECO:0000256|RuleBase:RU004064};
KW   RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Viral genome integration {ECO:0000256|ARBA:ARBA00023195};
KW   Virus entry into host cell {ECO:0000256|ARBA:ARBA00023195};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          20..89
FT                   /note="Peptidase A2"
FT                   /evidence="ECO:0000259|PROSITE:PS50175"
FT   DOMAIN          143..333
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:BAF99394.1"
FT   NON_TER         335
FT                   /evidence="ECO:0000313|EMBL:BAF99394.1"
SQ   SEQUENCE   335 AA;  38170 MW;  DDBEFEE74157E72C CRC64;
     PQITLWQRPL VTIRVGGQLK EALLDTGADD TVLEEMNLPG KWKPKMIGGI GGFIKVRQYD
     QITIEICGHK AIGTVLVGPT PVNIIGRNLL TQIGCTLNFP ISPIETVPVX LKPGMDGPKV
     KQWPLTEEKI KALIEICTEM EKEGKISKIG PENPYNTPIF AIKKKDSTKW RKLVDFRELN
     KRTQDFWEVQ LGIPHPAGLK KKKSVTVLDV GDAYFSVPLX XXFRKYTAFT IPSLNNETPG
     IRYQYNVLPQ GWKGSPAIFQ CSMTKILEPF RKQNPDIVIY QYMDDLYVGS DLEIEQHRAX
     IEELRQHLLX WGFTTPDKKH QKEPPFLWMG YELHP
//
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