ID B0KWJ2_CALJA Unreviewed; 420 AA.
AC B0KWJ2; F6T3R0;
DT 18-MAR-2008, integrated into UniProtKB/TrEMBL.
DT 18-MAR-2008, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=Mannose-1-phosphate guanyltransferase alpha {ECO:0000256|ARBA:ARBA00040222};
DE AltName: Full=GDP-mannose pyrophosphorylase A {ECO:0000256|ARBA:ARBA00042915};
DE AltName: Full=GTP-mannose-1-phosphate guanylyltransferase alpha {ECO:0000256|ARBA:ARBA00041992};
GN Name=GMPPA {ECO:0000313|EMBL:ABY89807.1};
GN Synonyms=ASIC4 {ECO:0000313|Ensembl:ENSCJAP00000021771.3};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|EMBL:ABY89807.1};
RN [1] {ECO:0000313|EMBL:ABY89807.1}
RP NUCLEOTIDE SEQUENCE.
RA Antonellis A., Benjamin B., Blakesley R.W., Bouffard G.G., Brinkley C.,
RA Brooks S., Chu G., Chub I., Coleman H., Fuksenko T., Gestole M.,
RA Gregory M., Guan X., Gupta J., Gurson N., Han E., Han J., Hansen N.,
RA Hargrove A., Hines-Harris K., Ho S.-L., Hu P., Hunter G., Hurle B.,
RA Idol J.R., Johnson T., Knight E., Kwong P., Lee-Lin S.-Q., Legaspi R.,
RA Madden M., Maduro Q.L., Maduro V.B., Margulies E.H., Masiello C.,
RA Maskeri B., McDowell J., Merkulov G., Montemayor C., Mullikin J.C.,
RA Park M., Prasad A., Ramsahoye C., Reddix-Dugue N., Riebow N., Schandler K.,
RA Schueler M.G., Sison C., Smith L., Stantripop S., Thomas J.W., Thomas P.J.,
RA Tsipouri V., Young A., Green E.D.;
RT "NISC Comparative Sequencing Initiative.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000021771.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:JAB09082.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Bladder {ECO:0000313|EMBL:JAB09082.1}, Cerebellum
RC {ECO:0000313|EMBL:JAB42566.1}, Cerebral cortex
RC {ECO:0000313|EMBL:JAB32025.1}, and Hippocampus
RC {ECO:0000313|EMBL:JAB17659.1};
RX PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT "De novo assembly of the common marmoset transcriptome from NextGen mRNA
RT sequences.";
RL Gigascience 3:14-14(2014).
RN [4] {ECO:0000313|Ensembl:ENSCJAP00000021771.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May serve as a regulatory subunit and allow allosteric
CC feedback inhibition of GMPPB by GDP-mannose.
CC {ECO:0000256|ARBA:ARBA00037787}.
CC -!- SIMILARITY: Belongs to the transferase hexapeptide repeat family.
CC {ECO:0000256|ARBA:ARBA00007274}.
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DR EMBL; DP000580; ABY89807.1; -; Genomic_DNA.
DR EMBL; GAMT01002779; JAB09082.1; -; mRNA.
DR EMBL; GAMS01005477; JAB17659.1; -; mRNA.
DR EMBL; GAMR01001907; JAB32025.1; -; mRNA.
DR EMBL; GAMP01010189; JAB42566.1; -; mRNA.
DR RefSeq; XP_002749862.1; XM_002749816.3.
DR RefSeq; XP_008997800.1; XM_008999552.2.
DR RefSeq; XP_008997801.1; XM_008999553.2.
DR Ensembl; ENSCJAT00000023012.5; ENSCJAP00000021771.3; ENSCJAG00000011864.5.
DR GeneID; 100402358; -.
DR KEGG; cjc:100402358; -.
DR CTD; 29926; -.
DR eggNOG; KOG1460; Eukaryota.
DR GeneTree; ENSGT00940000159052; -.
DR HOGENOM; CLU_029499_3_0_1; -.
DR OrthoDB; 5486038at2759; -.
DR TreeFam; TF300832; -.
DR Proteomes; UP000008225; Chromosome 6.
DR Bgee; ENSCJAG00000011849; Expressed in ovary and 6 other cell types or tissues.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR CDD; cd06428; M1P_guanylylT_A_like_N; 1.
DR Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 1.
DR InterPro; IPR001451; Hexapep.
DR InterPro; IPR018357; Hexapep_transf_CS.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR22572:SF104; MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE ALPHA; 1.
DR PANTHER; PTHR22572; SUGAR-1-PHOSPHATE GUANYL TRANSFERASE; 1.
DR Pfam; PF00132; Hexapep; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR PROSITE; PS00101; HEXAPEP_TRANSFERASES; 1.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Transferase {ECO:0000313|EMBL:JAB09082.1}.
FT DOMAIN 3..195
FT /note="Nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF00483"
SQ SEQUENCE 420 AA; 46292 MW; 69DC64F2F756BF21 CRC64;
MLKAVILIGG PQKGTRFRPL SFEVPKPLFP VAGVPMIQHH IEACAQVPGM QEILLIGFYQ
PDEPLTQFLE AAQQEFHLPV RYLQEFAPLG TGGGLYHFRD QILAGGPEAF FVLNADVCSD
FPLSAMLEAH RRQRHPFLLL GTTANRTQSL NYGCIVENPQ THEVLHYVEK PSTFISDIIN
CGIYLFSPEA LKPLRDVFQR NQQDGQLEDS PGLWPGAGTI RLEQDVFSAL AGQGQIYVHL
TDGIWSQIKS AGSALYASRL YLSRYQNTHP ERLAKHIPGG PRIRGNVYIH PTAKVAPSAV
LGPNVSIGKG VTVGEGVRLR ESIVLHGATL QEHTCVLHSI VGWGSTVGRW ARVEGTPNDP
NPNDPRARMD SESLFKDGKL LPAITILGCR VRIPAEVLIL NSIVLPHKEL SRSFTNQIIL
//
