ID B0R9J1_HALS3 Unreviewed; 308 AA.
AC B0R9J1;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 2.
DT 24-JAN-2024, entry version 93.
DE RecName: Full=Transcription initiation factor IIB {ECO:0000256|HAMAP-Rule:MF_00383};
DE Short=TFIIB {ECO:0000256|HAMAP-Rule:MF_00383};
GN Name=tfbH {ECO:0000313|EMBL:CAP15279.2};
GN Synonyms=tfb {ECO:0000256|HAMAP-Rule:MF_00383};
GN OrderedLocusNames=OE_6140R {ECO:0000313|EMBL:CAP15279.2};
OS Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1).
OG Plasmid PHS2 {ECO:0000313|EMBL:CAP15279.2,
OG ECO:0000313|Proteomes:UP000001321}.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Halobacteriaceae; Halobacterium; Halobacterium salinarum NRC-34001.
OX NCBI_TaxID=478009 {ECO:0000313|EMBL:CAP15279.2, ECO:0000313|Proteomes:UP000001321};
RN [1] {ECO:0000313|EMBL:CAP15279.2, ECO:0000313|Proteomes:UP000001321}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29341 / DSM 671 / R1 {ECO:0000313|Proteomes:UP000001321};
RC PLASMID=Plasmid PHS2 {ECO:0000313|Proteomes:UP000001321};
RX PubMed=18313895; DOI=.1016/j.ygeno.2008.01.001;
RA Pfeiffer F., Schuster S.C., Broicher A., Falb M., Palm P., Rodewald K.,
RA Ruepp A., Soppa J., Tittor J., Oesterhelt D.;
RT "Evolution in the laboratory: the genome of Halobacterium salinarum strain
RT R1 compared to that of strain NRC-1.";
RL Genomics 91:335-346(2008).
CC -!- FUNCTION: Stabilizes TBP binding to an archaeal box-A promoter. Also
CC responsible for recruiting RNA polymerase II to the pre-initiation
CC complex (DNA-TBP-TFIIB). {ECO:0000256|HAMAP-Rule:MF_00383}.
CC -!- SIMILARITY: Belongs to the TFIIB family. {ECO:0000256|HAMAP-
CC Rule:MF_00383}.
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DR EMBL; AM774417; CAP15279.2; -; Genomic_DNA.
DR RefSeq; WP_049892660.1; NC_010369.1.
DR AlphaFoldDB; B0R9J1; -.
DR EnsemblBacteria; CAP15279; CAP15279; OE_6140R.
DR GeneID; 5955078; -.
DR KEGG; hsl:OE_6140R; -.
DR HOGENOM; CLU_043736_0_0_2; -.
DR PhylomeDB; B0R9J1; -.
DR Proteomes; UP000001321; Plasmid PHS2.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0017025; F:TBP-class protein binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0070897; P:transcription preinitiation complex assembly; IEA:InterPro.
DR Gene3D; 1.10.472.170; -; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 1.
DR HAMAP; MF_00383; TF2B_arch; 1.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR000812; TFIIB.
DR InterPro; IPR023484; TFIIB_arc.
DR InterPro; IPR013150; TFIIB_cyclin.
DR InterPro; IPR013137; Znf_TFIIB.
DR PANTHER; PTHR11618:SF13; TRANSCRIPTION INITIATION FACTOR IIB; 1.
DR PANTHER; PTHR11618; TRANSCRIPTION INITIATION FACTOR IIB-RELATED; 1.
DR Pfam; PF08271; TF_Zn_Ribbon; 1.
DR Pfam; PF00382; TFIIB; 2.
DR PRINTS; PR00685; TIFACTORIIB.
DR SUPFAM; SSF47954; Cyclin-like; 2.
DR SUPFAM; SSF57783; Zinc beta-ribbon; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|HAMAP-Rule:MF_00383};
KW Plasmid {ECO:0000313|EMBL:CAP15279.2};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|HAMAP-Rule:MF_00383};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_00383};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW Rule:MF_00383}; Zinc {ECO:0000256|HAMAP-Rule:MF_00383};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 23..61
FT /note="TFIIB-type"
FT /evidence="ECO:0000259|Pfam:PF08271"
FT DOMAIN 123..210
FT /note="Transcription factor TFIIB cyclin-like"
FT /evidence="ECO:0000259|Pfam:PF00382"
FT REPEAT 130..213
FT /note="1"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00383"
FT DOMAIN 219..298
FT /note="Transcription factor TFIIB cyclin-like"
FT /evidence="ECO:0000259|Pfam:PF00382"
FT REPEAT 224..305
FT /note="2"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00383"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 62..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 24
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00383"
FT BINDING 27
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00383"
FT BINDING 40
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00383"
FT BINDING 43
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00383"
SQ SEQUENCE 308 AA; 33951 MW; D6E88443ACDB4926 CRC64;
MATSEIYETT FDEDVQTDSS AKQCPECDGR VTTNTVETVC EDCGLVVDEQ RIDHGPEWRA
FDEDERERTG APLTATRHDR GLSTEIGRGT DANGNRLSGR KRRQVARMRR EQSRGRFQSK
AERNLAHGLG EVRRIVSALE LSEMIRDQAC QLFRSAQNED LLQGRSIEAM ATASVYGACR
CDGLSRTLED VTDPARVEQS RVTNAYKTLN TELGLPAQPV TPSAFVPRLA SELDVSDQIR
QRARQLAEAS ESTGATTGVQ PSGFAAACLY KAGREDGRWL TQSDIAEVAN VSVVTVRTHR
DTLDELAV
//
