ID B0S2H4_FINM2 Unreviewed; 1401 AA.
AC B0S2H4;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=2-hydroxyglutaryl-CoA dehydratase {ECO:0008006|Google:ProtNLM};
GN OrderedLocusNames=FMG_1146 {ECO:0000313|EMBL:BAG08564.1};
OS Finegoldia magna (strain ATCC 29328 / DSM 20472 / WAL 2508)
OS (Peptostreptococcus magnus).
OC Bacteria; Bacillota; Tissierellia; Tissierellales; Peptoniphilaceae;
OC Finegoldia.
OX NCBI_TaxID=334413 {ECO:0000313|EMBL:BAG08564.1, ECO:0000313|Proteomes:UP000001319};
RN [1] {ECO:0000313|EMBL:BAG08564.1, ECO:0000313|Proteomes:UP000001319}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29328 / DSM 20472 / WAL 2508
RC {ECO:0000313|Proteomes:UP000001319};
RX PubMed=18263572; DOI=10.1093/dnares/dsm030;
RA Goto T., Yamashita A., Hirakawa H., Matsutani M., Todo K., Ohshima K.,
RA Toh H., Miyamoto K., Kuhara S., Hattori M., Shimizu T., Akimoto S.;
RT "Complete genome sequence of Finegoldia magna, an anaerobic opportunistic
RT pathogen.";
RL DNA Res. 15:39-47(2008).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; AP008971; BAG08564.1; -; Genomic_DNA.
DR RefSeq; WP_012290852.1; NC_010376.1.
DR STRING; 334413.FMG_1146; -.
DR KEGG; fma:FMG_1146; -.
DR eggNOG; COG1924; Bacteria.
DR eggNOG; COG3580; Bacteria.
DR eggNOG; COG3581; Bacteria.
DR HOGENOM; CLU_002393_1_0_9; -.
DR Proteomes; UP000001319; Chromosome.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.420.40; -; 4.
DR InterPro; IPR002731; ATPase_BadF.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR018709; CoA_activase_DUF2229.
DR InterPro; IPR008275; CoA_E_activase_dom.
DR NCBIfam; TIGR00241; CoA_E_activ; 1.
DR PANTHER; PTHR32329:SF4; ACTIVATOR OF 2-HYDROXYACYL-COA DEHYDRATASE-RELATED; 1.
DR PANTHER; PTHR32329; BIFUNCTIONAL PROTEIN [INCLUDES 2-HYDROXYACYL-COA DEHYDRATASE (N-TER) AND ITS ACTIVATOR DOMAIN (C_TERM)-RELATED; 1.
DR Pfam; PF01869; BcrAD_BadFG; 2.
DR Pfam; PF09989; DUF2229; 1.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023014};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00023014};
KW Reference proteome {ECO:0000313|Proteomes:UP000001319}.
FT DOMAIN 6..256
FT /note="ATPase BadF/BadG/BcrA/BcrD type"
FT /evidence="ECO:0000259|Pfam:PF01869"
FT DOMAIN 322..576
FT /note="ATPase BadF/BadG/BcrA/BcrD type"
FT /evidence="ECO:0000259|Pfam:PF01869"
FT DOMAIN 669..886
FT /note="DUF2229"
FT /evidence="ECO:0000259|Pfam:PF09989"
SQ SEQUENCE 1401 AA; 157708 MW; 9DAE7C93D7080E05 CRC64;
MKIHMGLDVG STTVKLVIIN ENYEILFQEY TRHRSDIEET TKNVLRQAYD SHPEFKNSDC
TIMVTGSGGM YVEDNLNIEF IQEVVAGTTA IKKYIPNADV CIELGGEDSK ITYLKGNVEQ
RMNSICAGGT GAFIDQMAAL LKTDATGLNE LAKDYKKIFS IASRCGVYAK TDIQALINQG
ATKEDMAVSV FQSVVNQTIS NLACGRPIEG NIVFLGGPLY FLSELRNRFI TTLDDGVNTF
YSPDNAQVFV ALGAAIASMN EESIKYEDLL NRSYDKKQEI SDDLILEPLF KNEKEKEDFY
ENHKKSNVKF KNIDEVEGNL YLGIDAGSTT SKIVVIDEDC NIVYHFYANN QGNPLDLVKE
QLSVIYSKLN ENQKIASSGI TGYGEDFIKQ ALSVDFGEVE TIAHLTAARY FDPDVDFVLD
IGGQDMKAMH VNDGIIDSIQ LNEACSSGCG SFIETFAHSL NLSVQEFQQK ALESENPVDL
GSRCTVFMNS KVKQAQKEGA SVSDIAAGLC YSVIKNAIQK VIKLRDPSKL GEHIVVQGGT
FYGDAILRAF EKITGKIPTR PNISGLMGAM GMALIAKEKS TGYSTILSED ELEKFEYTQE
QAECKYCSNH CKLTINKFAN GKKFVTGNRC ERGAGISLDK KDKLPNMYDY KNKRLFGYKS
IPKDKARATV GIPRVLNMYE NYPFWHTFFT NLGYRVVLSS KSSREIYEKG ISSITSETCC
YPAKLVHGHI EDLLEKNVDM IFYPSVFFEK QEYDKANNHI NCPVVTGYPE VIKNNVDGLK
NTKFFNPFIS FQDKNKLKTR LIDELKELAL SDKDISNSVD RAWDELEKYR KDVKVEGKKA
LSKIREMGKK AIVLAGRPYH VDSEINHGIP ELITSLGLGV LSEDSIIDYD DDVDSDLRVL
DQWVYHSRLY RAAEIVGNSE DLEMVQLNSF GCGIDAVTTD QVNEILSAKG KIYTVLKIDE
ISNLGAVKIR IRSLIQALEK KNFIPNVKKS YHVEKVEFTK KMKDEYTILA PQMAPDHFEI
MEALFKASGY KVEFLKDVNS KVIDEGLKYV NNDACYPSIT VVGQMMEAIN SGRYDTNKLA
LLMSQTGGAC RASNYVGFIR KALKEAGYEN IPVIAISWQN IEKNEGFNLS PLVLQKMIVA
VLYGDLIMRL SNFTRAYEKD KQTDALKQKW IEECQKRVLK SSSKLFRQTV DEIIEDFSKI
ELLDIQKPKV GIVGEILVKY LPQANNNLQD LLEKEGCEVV MPDLTDFVLY CLRNEYHKGN
FLSKSKFTGF MCNMGVNLIE HYRKYIRNQL IKSKFTHPLK IQELEDYAQE VVSLGNQYGE
GWLLTAEMIE LIHINANNIV CIQPFGCLPN HITGKGVIKR IRQLYPQANI IPIDYDPGAS
EVNQINRIKL MLSQAKEKIN N
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