ID B0S522_DANRE Unreviewed; 467 AA.
AC B0S522; A0A8N7UZ02;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 105.
DE SubName: Full=RNA-binding motif protein 45 {ECO:0000313|Ensembl:ENSDARP00000087847};
DE SubName: Full=RNA-binding protein 45 {ECO:0000313|RefSeq:NP_001120874.1, ECO:0000313|RefSeq:XP_005172566.1};
GN Name=rbm45 {ECO:0000313|Ensembl:ENSDARP00000087847,
GN ECO:0000313|RefSeq:NP_001120874.1, ECO:0000313|RefSeq:XP_005172566.1,
GN ECO:0000313|ZFIN:ZDB-GENE-070122-4};
GN Synonyms=drb1 {ECO:0000313|RefSeq:NP_001120874.1,
GN ECO:0000313|RefSeq:XP_005172566.1}, si:ch211-222f23.2
GN {ECO:0000313|RefSeq:NP_001120874.1,
GN ECO:0000313|RefSeq:XP_005172566.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000087847};
RN [1] {ECO:0000313|RefSeq:NP_001120874.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001120874.1};
RX PubMed=18803835;
RA Sundstrom G., Larsson T.A., Larhammar D.;
RT "Phylogenetic and chromosomal analyses of multiple gene families syntenic
RT with vertebrate Hox clusters.";
RL BMC Evol. Biol. 8:254-254(2008).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000087847, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000087847};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|Ensembl:ENSDARP00000087847}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000087847};
RG Ensembl;
RL Submitted (AUG-2013) to UniProtKB.
RN [4] {ECO:0000313|RefSeq:NP_001120874.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001120874.1};
RX PubMed=27189481;
RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA Bobe J.;
RT "Gene evolution and gene expression after whole genome duplication in fish:
RT the PhyloFish database.";
RL BMC Genomics 17:368-368(2016).
RN [5] {ECO:0000313|RefSeq:NP_001120874.1, ECO:0000313|RefSeq:XP_005172566.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001120874.1,
RC ECO:0000313|RefSeq:XP_005172566.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; BX004991; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001120874.1; NM_001127402.1.
DR RefSeq; XP_005172566.1; XM_005172509.4.
DR STRING; 7955.ENSDARP00000145527; -.
DR PaxDb; 7955-ENSDARP00000087847; -.
DR Ensembl; ENSDART00000093415.7; ENSDARP00000087847.5; ENSDARG00000063731.7.
DR Ensembl; ENSDART00000181215.1; ENSDARP00000145527.1; ENSDARG00000063731.7.
DR GeneID; 568524; -.
DR KEGG; dre:568524; -.
DR AGR; ZFIN:ZDB-GENE-070122-4; -.
DR CTD; 129831; -.
DR ZFIN; ZDB-GENE-070122-4; rbm45.
DR eggNOG; ENOG502QTJ8; Eukaryota.
DR HOGENOM; CLU_035274_1_1_1; -.
DR OMA; MIPKTYT; -.
DR OrthoDB; 312623at2759; -.
DR TreeFam; TF324216; -.
DR Proteomes; UP000000437; Chromosome 9.
DR Bgee; ENSDARG00000063731; Expressed in blastula and 16 other cell types or tissues.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd12366; RRM1_RBM45; 1.
DR CDD; cd12367; RRM2_RBM45; 1.
DR CDD; cd12368; RRM3_RBM45; 1.
DR CDD; cd12369; RRM4_RBM45; 1.
DR Gene3D; 3.30.70.330; -; 4.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR034203; RBM45_RRM1.
DR InterPro; IPR034206; RBM45_RRM2.
DR InterPro; IPR034207; RBM45_RRM3.
DR InterPro; IPR034208; RBM45_RRM4.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR48025; OS02G0815200 PROTEIN; 1.
DR PANTHER; PTHR48025:SF22; OS02G0815200 PROTEIN; 1.
DR Pfam; PF00076; RRM_1; 4.
DR SMART; SM00360; RRM; 4.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 2.
DR PROSITE; PS50102; RRM; 4.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|PeptideAtlas:B0S522};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}.
FT DOMAIN 17..96
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 111..185
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 234..311
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 383..455
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 186..207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 467 AA; 52085 MW; 8D9EFB604ACEC206 CRC64;
MDDSNRPSSY LDEPPNSRLF LVTSKSITED TIRESFASFG EIQDIWVVKD KQTKESKGVA
FIKFAKSSQA CTAMEEMHGR CLAEGTKPIK VFIAQSRSSG SHRDVEDEEL TRIFVMIPKT
FTEDDLKETF KVYGDIEYAI IIRNKTTGDS KGLGYVRFHK PSQAAKAVEN CDKTFRAIIA
EPRTKNSSAD NDYFSNPRTT EHSTSELGSS SYAFAQESSS YSAAESYSSD IITRCLMVSS
RVSVSQEQIY SLFDLIPGLD YCEIQRDQYG FSKGQVVVRY SNLGSAVYAK EKLNGFEYPP
GNRLSVSFVD DGEDRTSPVG KMAMQLVAAQ MMSMVWNGPS GSQLMKTSAG YTAPPVPQKA
RLQTDANLPA PKKLLALDSV VKERLFVIFN PSPLPVEVLE DVFCRFGSLI EVYLVPGRNV
GYIKYADRRS AHDAIDTMHG KVVNGVKMKV MLADPPKEES HKRQRTY
//
