GenomeNet

Database: UniProt
Entry: B0S7L9_DANRE
LinkDB: B0S7L9_DANRE
Original site: B0S7L9_DANRE 
ID   B0S7L9_DANRE            Unreviewed;      1785 AA.
AC   B0S7L9;
DT   08-APR-2008, integrated into UniProtKB/TrEMBL.
DT   08-APR-2008, sequence version 1.
DT   20-DEC-2017, entry version 91.
DE   SubName: Full=Kinesin family member 1Ab {ECO:0000313|Ensembl:ENSDARP00000119750};
GN   Name=kif1ab {ECO:0000313|Ensembl:ENSDARP00000119750,
GN   ECO:0000313|ZFIN:ZDB-GENE-070912-480};
GN   Synonyms=si:dkey-261l2.2 {ECO:0000313|ZFIN:ZDB-GENE-070912-480};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000119750, ECO:0000313|Proteomes:UP000000437};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000119750, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000119750,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000119750}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000119750};
RG   Ensembl;
RL   Submitted (AUG-2013) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC       superfamily. Kinesin family. {ECO:0000256|PROSITE-
CC       ProRule:PRU00283, ECO:0000256|SAAS:SAAS00583243}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSDARP00000119750}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; BX649390; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BX897733; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; B0S7L9; -.
DR   STRING; 7955.ENSDARP00000119750; -.
DR   PaxDb; B0S7L9; -.
DR   PeptideAtlas; B0S7L9; -.
DR   Ensembl; ENSDART00000139196; ENSDARP00000119750; ENSDARG00000062024.
DR   ZFIN; ZDB-GENE-070912-480; kif1ab.
DR   eggNOG; KOG0245; Eukaryota.
DR   eggNOG; COG5059; LUCA.
DR   GeneTree; ENSGT00890000139327; -.
DR   HOGENOM; HOG000165968; -.
DR   HOVERGEN; HBG052251; -.
DR   InParanoid; B0S7L9; -.
DR   OMA; HCVFRSD; -.
DR   OrthoDB; EOG091G009V; -.
DR   PhylomeDB; B0S7L9; -.
DR   TreeFam; TF105221; -.
DR   Proteomes; UP000000437; Chromosome 2.
DR   Bgee; ENSDARG00000062024; -.
DR   ExpressionAtlas; B0S7L9; baseline.
DR   GO; GO:0005871; C:kinesin complex; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATPase activity; IBA:GO_Central.
DR   GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR   GO; GO:0003777; F:microtubule motor activity; IBA:GO_Central.
DR   GO; GO:0030705; P:cytoskeleton-dependent intracellular transport; IBA:GO_Central.
DR   GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR   CDD; cd00060; FHA; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   Gene3D; 3.40.850.10; -; 1.
DR   InterPro; IPR000253; FHA_dom.
DR   InterPro; IPR022164; Kinesin-like.
DR   InterPro; IPR027640; Kinesin-like_fam.
DR   InterPro; IPR022140; Kinesin-like_KIF1-typ.
DR   InterPro; IPR032405; Kinesin_assoc.
DR   InterPro; IPR019821; Kinesin_motor_CS.
DR   InterPro; IPR001752; Kinesin_motor_dom.
DR   InterPro; IPR036961; Kinesin_motor_dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR008984; SMAD_FHA_dom_sf.
DR   PANTHER; PTHR24115; PTHR24115; 1.
DR   Pfam; PF12473; DUF3694; 1.
DR   Pfam; PF00498; FHA; 1.
DR   Pfam; PF12423; KIF1B; 1.
DR   Pfam; PF00225; Kinesin; 1.
DR   Pfam; PF16183; Kinesin_assoc; 1.
DR   Pfam; PF00169; PH; 1.
DR   PRINTS; PR00380; KINESINHEAVY.
DR   SMART; SM00240; FHA; 1.
DR   SMART; SM00129; KISc; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF49879; SSF49879; 1.
DR   SUPFAM; SSF50729; SSF50729; 2.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS50006; FHA_DOMAIN; 1.
DR   PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR   PROSITE; PS50067; KINESIN_MOTOR_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00283,
KW   ECO:0000256|SAAS:SAAS00875240}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00283,
KW   ECO:0000256|SAAS:SAAS00874078};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT   DOMAIN        5    348       Kinesin motor. {ECO:0000259|PROSITE:
FT                                PS50067}.
FT   DOMAIN      533    589       FHA. {ECO:0000259|PROSITE:PS50006}.
FT   DOMAIN     1670   1768       PH. {ECO:0000259|PROSITE:PS50003}.
FT   NP_BIND      96    103       ATP. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00283}.
FT   COILED      447    474       {ECO:0000256|SAM:Coils}.
FT   COILED      645    694       {ECO:0000256|SAM:Coils}.
FT   COILED      819    839       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1785 AA;  202332 MW;  D32BFD33E72EEF5E CRC64;
     MAGASVKVAV RVRPFNSREI GKDSKCIIQM SGNTTTILNP KQPKENKSFN FDYSYWSHTT
     PEDVNYACQK QVYRDIGEEM LLHAFEGYNV CIFAYGQTGA GKSYTMMGKQ EKDQEGIIPL
     LCEDLFTKIN DNNDNNMSYS VEVSYMEIYC ERVRDLLNPK NKGNLRVREH PLMGPYVEDL
     SKLAVTSYND IQDLMDSGNK ARTVAATNMN ETSSRSHAVF NIIFTQKQHD NDSENTTEKV
     SKISLVDLAG SERADSTGAK GTRLKEGANI NKSLTTLGKV ISALAEMNKK KKKVESFIPY
     RDSVLTWLLR ENLGGNSRTA MVAALSPADI NYDETLSTLR YADRAKQIRC NAVINEDPNN
     RLVRELKEEV ARLKDLLYAQ GLGDIIENLS NYKANISSIQ AVNQRGDFST VTNAMTGMSP
     SPSLSALTSR VGSISSLHDR IMFSPGSEEA IERLKETEKI IAELNETWEE KLRRTEAIRM
     EREALLAEMG VAMREDGGTV GVFSPKKTPH LVNLNEDPLM SECLLYYIKD GITKVGREDA
     SSRQDIVLSG HFIKDEHCIF TSTTNAIGEG TVVLEPCEGA ETYVNGKRVT EPTVLKSGNR
     IIMGKSHVFR FNDPEQARQD RERTPCADTP VEPVDWAFAQ RELLEKQGID MKQEMDQRLQ
     ELEDQYRKER EEASNLLEQQ RLDYESKLEA LQKQVNSRYY PETTEEEEEL EDEVPWTKRE
     TELALWAFRK WRFYQFTSLR DLLWGNAIFL KEANAISVEL KKKVQFQFVL LTDTLYSPLP
     PDLLPPSIAK DREKRLFPRT IVAVEVQDQK NGATHYWTLD KLRQRLDLMR EMYDRAAEVP
     STAVEDCDHI MSGGDPFYDR FPWFRLVGRT PILNTCMSER MSGLTLSPTL SDPDSDITEL
     ADERHYGKVE VEEEELEDLD DEIFVEDNGS ELGREEEEDD DDGVGERCPG VSDGQDPFYD
     RWPLFSLVGR AFVYLSNLLY PVPLVHRVAI VSEKGEVKGF LRVAVQAISA DEEAPDYGSG
     VRQSGTAKIS FEDQAFEKFQ TEACTSGMSQ THTSEEELRI VEGEGQNSEL GLSADEVNNN
     TCLVSPDISD SPLKGVLECP LDVTQDKSLQ HLKIGSNFTF RVTVLQASSI SAEYADIFCQ
     FNFIHRHDEA FSTEPLKNTG RGPPLGFYHV QNITVEVTKS FVEYIKSQPI VFEVFGHYQK
     QPFPPLCKDL ISSLRPMRRQ FPRVMPLSKP VPATKLSTLA RSTAGPCHCK YDLMAFFEIC
     ELEANGDYIP AVVDHRGGMP CHGTFLLHQG IQRRITVTIA HETGNDIEWK EVKELVIGRI
     RNTPEADETI IDPNILSLNI LSSNYIRPTY DDRTFYRFEA AWDSSMHNSL LLNRVTPYGE
     KIYITLSAYL EMENCTQPTV VTKDFCMVFY SRDAKLPASR SIRNLFSTGA FRPLESNCVT
     GVYELSLCHL ADIGSPGMQR RRRRVLDTSV AYVRGEENLA GWRPRSDSLI LDHQWELEKL
     SLLQEVEKTR HYLLLREKLE ASLLLGQDSF YGKDLLDSPK ANSPMISPVM SLGLDSPNER
     QRELAAKCVR LLMHTFNRQY SQVSSSLSES KLSEISASLL RDSVTSPLSS LTPSSTCPSL
     LDGHYSTDLR GAEANSGASS PDLDPFSPIE RKPRTCTFIP NIQEIRVSPI VSKKGYLHFL
     EPHTSGWVKR YIVVRRPYVY LYRSERDYVE RAIINLSSAQ VEYSEDHHTL MRAPNTFTVC
     TEHRNILLQA TNDKEMHDWL YAFNPLLAGT IRSKLSRRKS GQMRM
//
DBGET integrated database retrieval system