ID B0SR82_LEPBP Unreviewed; 558 AA.
AC B0SR82;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 100.
DE RecName: Full=protein-secreting ATPase {ECO:0000256|ARBA:ARBA00024382};
DE EC=7.4.2.8 {ECO:0000256|ARBA:ARBA00024382};
GN Name=gspE {ECO:0000313|EMBL:ABZ97783.1};
GN OrderedLocusNames=LEPBI_I1676 {ECO:0000313|EMBL:ABZ97783.1};
OS Leptospira biflexa serovar Patoc (strain Patoc 1 / ATCC 23582 / Paris).
OC Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC Leptospira.
OX NCBI_TaxID=456481 {ECO:0000313|EMBL:ABZ97783.1, ECO:0000313|Proteomes:UP000001847};
RN [1] {ECO:0000313|EMBL:ABZ97783.1, ECO:0000313|Proteomes:UP000001847}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Patoc 1 / ATCC 23582 / Paris
RC {ECO:0000313|Proteomes:UP000001847};
RX PubMed=18270594; DOI=10.1371/journal.pone.0001607;
RA Picardeau M., Bulach D.M., Bouchier C., Zuerner R.L., Zidane N.,
RA Wilson P.J., Creno S., Kuczek E.S., Bommezzadri S., Davis J.C., McGrath A.,
RA Johnson M.J., Boursaux-Eude C., Seemann T., Rouy Z., Coppel R.L.,
RA Rood J.I., Lajus A., Davies J.K., Medigue C., Adler B.;
RT "Genome sequence of the saprophyte Leptospira biflexa provides insights
RT into the evolution of Leptospira and the pathogenesis of leptospirosis.";
RL PLoS ONE 3:E1607-E1607(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O + cellular proteinSide 1 = ADP + phosphate +
CC cellular proteinSide 2.; EC=7.4.2.8;
CC Evidence={ECO:0000256|ARBA:ARBA00034006};
CC -!- SIMILARITY: Belongs to the GSP E family.
CC {ECO:0000256|ARBA:ARBA00006611}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000786; ABZ97783.1; -; Genomic_DNA.
DR RefSeq; WP_012388661.1; NC_010602.1.
DR AlphaFoldDB; B0SR82; -.
DR STRING; 456481.LEPBI_I1676; -.
DR KEGG; lbi:LEPBI_I1676; -.
DR HOGENOM; CLU_013446_2_2_12; -.
DR OrthoDB; 9808272at2; -.
DR BioCyc; LBIF456481:LEPBI_RS08280-MONOMER; -.
DR Proteomes; UP000001847; Chromosome I.
DR GO; GO:0015627; C:type II protein secretion system complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0015628; P:protein secretion by the type II secretion system; IEA:InterPro.
DR CDD; cd01129; PulE-GspE-like; 1.
DR Gene3D; 3.30.450.90; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.30.300.160; Type II secretion system, protein E, N-terminal domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001482; T2SS/T4SS_dom.
DR InterPro; IPR037257; T2SS_E_N_sf.
DR InterPro; IPR013369; T2SS_GspE.
DR InterPro; IPR007831; T2SS_GspE_N.
DR NCBIfam; TIGR02533; type_II_gspE; 1.
DR PANTHER; PTHR30258:SF2; BACTERIOPHAGE ADSORPTION PROTEIN B; 1.
DR PANTHER; PTHR30258; TYPE II SECRETION SYSTEM PROTEIN GSPE-RELATED; 1.
DR Pfam; PF05157; MshEN; 1.
DR Pfam; PF00437; T2SSE; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF160246; EspE N-terminal domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00662; T2SP_E; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001847};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 378..392
FT /note="Bacterial type II secretion system protein E"
FT /evidence="ECO:0000259|PROSITE:PS00662"
SQ SEQUENCE 558 AA; 62417 MW; 140E0F4BB2FADAD3 CRC64;
MRKSLGQILL EDGILTIKDL EDISKQQEKT NLPLTHIIQK KGLASETDIL KALAKLHRME
FYDKLEFVAS DEIFSKIPLK LVQRSKIVPF LVKGKKVFVA TSDPTDLHPM DDMRSFLKGY
EIQFVLATEN EIMRIVHSQF DKTTAEAKEM MDEMDGSFGD LSDAFESDAL DLSNEAPIIK
MVNVILSQAV SERASDIHIE PFEKSVIVRY RVDGVLQKVL NPPKSYLAGI STRIKIMSNL
NIAENRLPQD GRIKLRLAGK DVDVRVSIIP CQFGERIVMR ILNKTDQKYS IDTMGFNPQI
LKEFKELIYK PYGIILVTGP TGSGKSTTLY SALSEINTEE RNIITCEDPV EYQMDGISQM
QMNDKIGLTF AAGLRSILRQ DPDVVMVGEI RDEETARIAI QASLTGHLVF STLHTNDASS
AVTRLVDMGI EPYLITSSVL GFMAQRLVRV ICKDCKTSYK PTDKDLAGLG IQRKELKNGV
LYRGKGCSSC LNSGYKGRTG LYELLTMNDE IKRAILQGAD ANRIKELAVK NGLSVLQEYG
KYKVIEGVTT PEEVLRVS
//
