ID   B0T0E4_CAUSK            Unreviewed;       804 AA.
AC   B0T0E4;
DT   08-APR-2008, integrated into UniProtKB/TrEMBL.
DT   08-APR-2008, sequence version 1.
DT   27-MAR-2024, entry version 87.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE   AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN   OrderedLocusNames=Caul_1460 {ECO:0000313|EMBL:ABZ70590.1};
OS   Caulobacter sp. (strain K31).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter.
OX   NCBI_TaxID=366602 {ECO:0000313|EMBL:ABZ70590.1};
RN   [1] {ECO:0000313|EMBL:ABZ70590.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K31 {ECO:0000313|EMBL:ABZ70590.1};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Bruce D., Goodwin L., Thompson L.S., Brettin T.,
RA   Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Kim E., Stephens C., Richardson P.;
RT   "Complete sequence of chromosome of Caulobacter sp. K31.";
RL   Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC         translocating in the 3'-5' direction.; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034617};
CC   -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC       {ECO:0000256|ARBA:ARBA00009922}.
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DR   EMBL; CP000927; ABZ70590.1; -; Genomic_DNA.
DR   AlphaFoldDB; B0T0E4; -.
DR   STRING; 366602.Caul_1460; -.
DR   KEGG; cak:Caul_1460; -.
DR   eggNOG; COG0210; Bacteria.
DR   HOGENOM; CLU_004585_5_2_5; -.
DR   OrthoDB; 9806690at2; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   CDD; cd17932; DEXQc_UvrD; 1.
DR   CDD; cd18807; SF1_C_UvrD; 1.
DR   Gene3D; 1.10.10.160; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}.
FT   DOMAIN          45..326
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   DOMAIN          327..594
FT                   /note="UvrD-like helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51217"
FT   REGION          1..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          718..737
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         66..73
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   804 AA;  89286 MW;  D77BC0E5BC979625 CRC64;
     MSSVFDSTPP VPTPADDFPG DLPAPRISDL ARPRGPDRPL PNYLEGLNPE QRAAVEATEG
     PVLVLAGAGT GKTRVLTTRL AHILATGRAR PWELLVVTFT NKAAREMRER ITHIIGDEAE
     GLRWLGTFHS VAAQILRRHA ELVGLKSSYT IIDTDDQERL MKQLIEADNI DSKRWTPRIL
     AGLIDTWKNR GWTPDRVPAS EAGEFANGKG IALYRQYQER LRILNACDFG DLLLHNITIF
     TGNPDVLADF QRRFQYVMVD EYQDTNVAQY LWLRLLAQGR QNVCCVGDDD QSIYGWRGAE
     VDNILRFERD FPGAKVIKLE RNYRSTEHIL AAASGLIDAN KSRLGKTLWT EETGGEKVKV
     SGVWDGEAES RMVADAIETA KKAGRKYSHM AILVRASFQM RAFEERFVML QIPYKVVGGP
     RFFERAEIRD AHAYLRLIQS PDDDLAFERI VNTPKRGIGD TSVTKLLQIA RSQGISTVDA
     ARVIIGGDDL PARTRTALSN FLRDLDRWRA LAANTPHQRV MEAVLEESGY TDALRLDKGP
     TSQTRLENLK ELVQSMSAFD TLEAYLEHVS LVMDLDKGAG DDAVWIMTLH SAKGLEFPLV
     FLPGWEEGVF PSQRSMDDKG EKGLEEERRL AYVGITRARE EARISFVANR QVYGRWTSQL
     PSRFVDELPL AHVDAASETG YYGGGPGMQQ TVASRWDEPA NTFTAGSYDS PGWKRAQDRA
     SGFGEKGSTW RAGGSAARSA PIEGEGRLVA VSASSAASDY TRGDRVFHVK FGYGKVTGVE
     GNKLSVAFDK AGDKKVIDSF VEKA
//