ID B0TH97_HELMI Unreviewed; 260 AA.
AC B0TH97;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 99.
DE RecName: Full=Global transcriptional regulator CodY {ECO:0000256|ARBA:ARBA00034538, ECO:0000256|HAMAP-Rule:MF_00621};
GN Name=codY {ECO:0000256|HAMAP-Rule:MF_00621,
GN ECO:0000313|EMBL:ABZ84772.1};
GN ORFNames=HM1_2216 {ECO:0000313|EMBL:ABZ84772.1};
OS Heliobacterium modesticaldum (strain ATCC 51547 / Ice1).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Heliobacteriaceae;
OC Heliomicrobium.
OX NCBI_TaxID=498761 {ECO:0000313|EMBL:ABZ84772.1, ECO:0000313|Proteomes:UP000008550};
RN [1] {ECO:0000313|EMBL:ABZ84772.1, ECO:0000313|Proteomes:UP000008550}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51547 / Ice1 {ECO:0000313|Proteomes:UP000008550};
RX PubMed=18441057; DOI=10.1128/JB.00299-08;
RA Sattley W.M., Madigan M.T., Swingley W.D., Cheung P.C., Clocksin K.M.,
RA Conrad A.L., Dejesa L.C., Honchak B.M., Jung D.O., Karbach L.E.,
RA Kurdoglu A., Lahiri S., Mastrian S.D., Page L.E., Taylor H.L., Wang Z.T.,
RA Raymond J., Chen M., Blankenship R.E., Touchman J.W.;
RT "The genome of Heliobacterium modesticaldum, a phototrophic representative
RT of the Firmicutes containing the simplest photosynthetic apparatus.";
RL J. Bacteriol. 190:4687-4696(2008).
CC -!- FUNCTION: DNA-binding global transcriptional regulator which is
CC involved in the adaptive response to starvation and acts by directly or
CC indirectly controlling the expression of numerous genes in response to
CC nutrient availability. During rapid exponential growth, CodY is highly
CC active and represses genes whose products allow adaptation to nutrient
CC depletion. {ECO:0000256|HAMAP-Rule:MF_00621}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00621}.
CC -!- SIMILARITY: Belongs to the CodY family. {ECO:0000256|HAMAP-
CC Rule:MF_00621}.
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DR EMBL; CP000930; ABZ84772.1; -; Genomic_DNA.
DR RefSeq; WP_012283272.1; NC_010337.2.
DR AlphaFoldDB; B0TH97; -.
DR STRING; 498761.HM1_2216; -.
DR KEGG; hmo:HM1_2216; -.
DR eggNOG; COG4465; Bacteria.
DR HOGENOM; CLU_089581_0_0_9; -.
DR OrthoDB; 2056at2; -.
DR Proteomes; UP000008550; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR HAMAP; MF_00621; HTH_type_CodY; 1.
DR InterPro; IPR014154; CodY.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR013198; GTP_trans_reg_CodY_C.
DR InterPro; IPR010312; Transc_reg_CodY_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR02787; codY_Gpos; 1.
DR PANTHER; PTHR40062:SF1; GLOBAL TRANSCRIPTIONAL REGULATOR CODY; 1.
DR PANTHER; PTHR40062; GTP-SENSING TRANSCRIPTIONAL PLEIOTROPIC REPRESSOR CODY; 1.
DR Pfam; PF06018; CodY; 1.
DR Pfam; PF08222; HTH_CodY; 1.
DR PIRSF; PIRSF011572; GTP_sensing_CodY; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00621};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00621}; Reference proteome {ECO:0000313|Proteomes:UP000008550};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|HAMAP-Rule:MF_00621};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_00621};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW Rule:MF_00621}.
FT DOMAIN 3..180
FT /note="Global transcriptional regulator CodY N-terminal"
FT /evidence="ECO:0000259|Pfam:PF06018"
FT DOMAIN 200..257
FT /note="Global transcriptional regulator CodY C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08222"
FT DNA_BIND 205..224
FT /note="H-T-H motif"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00621"
FT REGION 1..157
FT /note="GAF domain"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00621"
SQ SEQUENCE 260 AA; 29165 MW; 12094A30E15F7710 CRC64;
MRTLLEKTRT VNRLIQKSAG HPVNFEEMAK ITSELINANC YIIGRRGKIL GFNFMPHFAC
DIMADIVHHT ERFPECYNQD LLRINETQAN FSQVSNACVF NYGETCSHGH KLMTVIPILG
GGQRLGTLVL AKYNEEFTDE DLILAEYAAT VVGMEILRAK AERMEEEARK KAAVQIAIGT
LSYSELEAVE HIFSELEGNE GLLVASKIAD RVGITRSVIV NALRKFESAG VIESKSLGMK
GTYIRILNDN LMEELEKLRH
//
