ID B0UXR9_DANRE Unreviewed; 643 AA.
AC B0UXR9; A0A8M1REW3;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 116.
DE SubName: Full=Heat shock 70 kDa protein isoform X1 {ECO:0000313|RefSeq:XP_003198158.1};
DE SubName: Full=Heat shock cognate 70-kd protein, tandem duplicate 2 {ECO:0000313|Ensembl:ENSDARP00000103854};
GN Name=hsp70.1 {ECO:0000313|RefSeq:XP_003198158.1,
GN ECO:0000313|ZFIN:ZDB-GENE-990415-91};
GN Synonyms=hsp70.2 {ECO:0000313|ZFIN:ZDB-GENE-110405-1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000103854};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000103854, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000103854};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000103854}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000103854};
RG Ensembl;
RL Submitted (MAY-2013) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_003198158.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_003198158.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC {ECO:0000256|ARBA:ARBA00007381, ECO:0000256|RuleBase:RU003322}.
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DR EMBL; FP016243; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003198158.1; XM_003198110.5.
DR STRING; 7955.ENSDARP00000103854; -.
DR PaxDb; 7955-ENSDARP00000103854; -.
DR Ensembl; ENSDART00000111042; ENSDARP00000103854; ENSDARG00000092362.
DR Ensembl; ENSDART00000111042.5; ENSDARP00000103854.3; ENSDARG00000092362.4.
DR GeneID; 100126123; -.
DR AGR; ZFIN:ZDB-GENE-110405-1; -.
DR AGR; ZFIN:ZDB-GENE-990415-91; -.
DR CTD; 100126123; -.
DR ZFIN; ZDB-GENE-990415-91; hsp70.1.
DR ZFIN; ZDB-GENE-110405-1; hsp70.2.
DR eggNOG; KOG0101; Eukaryota.
DR HOGENOM; CLU_005965_3_0_1; -.
DR OMA; IDYYSTI; -.
DR OrthoDB; 143at2759; -.
DR PhylomeDB; B0UXR9; -.
DR TreeFam; TF105042; -.
DR Reactome; R-DRE-3371453; Regulation of HSF1-mediated heat shock response.
DR Reactome; R-DRE-3371497; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand.
DR Reactome; R-DRE-3371568; Attenuation phase.
DR Reactome; R-DRE-3371571; HSF1-dependent transactivation.
DR Reactome; R-DRE-450408; AUF1 (hnRNP D0) binds and destabilizes mRNA.
DR Reactome; R-DRE-6798695; Neutrophil degranulation.
DR Reactome; R-DRE-9833482; PKR-mediated signaling.
DR Proteomes; UP000000437; Chromosome 3.
DR Bgee; ENSDARG00000092362; Expressed in spleen and 20 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; ISS:AgBase.
DR GO; GO:0005634; C:nucleus; ISS:AgBase.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR GO; GO:0031072; F:heat shock protein binding; IBA:GO_Central.
DR GO; GO:0044183; F:protein folding chaperone; IBA:GO_Central.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IBA:GO_Central.
DR GO; GO:0048593; P:camera-type eye morphogenesis; IMP:ZFIN.
DR GO; GO:0051085; P:chaperone cofactor-dependent protein refolding; IBA:GO_Central.
DR GO; GO:0042026; P:protein refolding; IBA:GO_Central.
DR GO; GO:0046686; P:response to cadmium ion; IEP:ZFIN.
DR GO; GO:0009408; P:response to heat; IDA:ZFIN.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IDA:ZFIN.
DR CDD; cd10233; HSPA1-2_6-8-like_NBD; 1.
DR Gene3D; 1.20.1270.10; -; 1.
DR Gene3D; 3.30.30.30; -; 1.
DR Gene3D; 3.30.420.40; -; 2.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR018181; Heat_shock_70_CS.
DR InterPro; IPR029048; HSP70_C_sf.
DR InterPro; IPR029047; HSP70_peptide-bd_sf.
DR InterPro; IPR013126; Hsp_70_fam.
DR PANTHER; PTHR19375:SF547; HEAT SHOCK COGNATE 70-KD PROTEIN, TANDEM DUPLICATE 3-RELATED; 1.
DR PANTHER; PTHR19375; HEAT SHOCK PROTEIN 70KDA; 1.
DR Pfam; PF00012; HSP70; 1.
DR PRINTS; PR00301; HEATSHOCK70.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR SUPFAM; SSF100934; Heat shock protein 70kD (HSP70), C-terminal subdomain; 1.
DR SUPFAM; SSF100920; Heat shock protein 70kD (HSP70), peptide-binding domain; 1.
DR PROSITE; PS00297; HSP70_1; 1.
DR PROSITE; PS00329; HSP70_2; 1.
DR PROSITE; PS01036; HSP70_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU003322};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003322};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Stress response {ECO:0000313|RefSeq:XP_003198158.1}.
FT REGION 620..643
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 643 AA; 70442 MW; CBB52EE9DF379F2D CRC64;
MSSPKGIAIG IDLGTTYSCV GVFQHGKVEI IANDQGNRTT PSYVAFTDTE RLIGDAAKNQ
VAMNPNNTVF DAKRLIGRRF DDPVVQSDMK HWSFKVVSDG GKPKVAVEHK GENKTFNPEE
ISSMVLVKMK EIAEAYLGQK VTNAVITVPA YFNDSQRQAT KDAGVIAGLN VLRIINEPTA
AAIAYGLDKG KSSERNVLIF DLGGGTFDVS ILTIEDGIFE VKATAGDTHL GGEDFDNRMV
NHFVEEFKRK HKKDISQNKR ALRRLRTACE RAKRTLSSSS QASIEIDSLY EGIDFYTSIT
RARFEELCSD LFRGTLDPVE KALRDAKMDK AQIHDIVLVG GSTRIPKIQK LLQDFFNGRE
LNKSINPDEA VAYGAAVQAA ILMGDTSGNV QDLLLLDVAP LSLGIETAGG VMTALIKRNT
TIPTKQTQTF STYSDNQPGV LIQVFEGERA MTKDNNLLGK FELTGIPPAP RGVPQIEVTF
DIDANGILNV SAADKSTGKQ NKITITNDKG RLSKEEIERM VQEADNYKAE DDLQREKISA
KNSLESYAFN MKNSVEDDNL KGKISEEDKK RVIEKCNEAV SWLENNQLAD KEEYEHQLKE
LEKVCNPVIS KLYQGGMPAG GCGAQARGAS GASAQGPTIE EVD
//
