GenomeNet

Database: UniProt
Entry: B0UYH2_DANRE
LinkDB: B0UYH2_DANRE
Original site: B0UYH2_DANRE 
ID   B0UYH2_DANRE            Unreviewed;       590 AA.
AC   B0UYH2;
DT   08-APR-2008, integrated into UniProtKB/TrEMBL.
DT   08-APR-2008, sequence version 1.
DT   25-OCT-2017, entry version 64.
DE   SubName: Full=Eukaryotic translation initiation factor 2D {ECO:0000313|Ensembl:ENSDARP00000009582};
GN   Name=eif2d {ECO:0000313|Ensembl:ENSDARP00000009582,
GN   ECO:0000313|ZFIN:ZDB-GENE-040426-1226};
GN   Synonyms=lgtn {ECO:0000313|ZFIN:ZDB-GENE-040426-1226};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000009582, ECO:0000313|Proteomes:UP000000437};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000009582, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000009582,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000009582}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000009582};
RG   Ensembl;
RL   Submitted (AUG-2013) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSDARP00000009582}.
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DR   EMBL; CR450833; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; B0UYH2; -.
DR   STRING; 7955.ENSDARP00000009582; -.
DR   PaxDb; B0UYH2; -.
DR   PeptideAtlas; B0UYH2; -.
DR   Ensembl; ENSDART00000013446; ENSDARP00000009582; ENSDARG00000012929.
DR   ZFIN; ZDB-GENE-040426-1226; eif2d.
DR   eggNOG; KOG2522; Eukaryota.
DR   eggNOG; ENOG410XSAV; LUCA.
DR   GeneTree; ENSGT00550000074865; -.
DR   HOGENOM; HOG000043078; -.
DR   HOVERGEN; HBG006268; -.
DR   InParanoid; B0UYH2; -.
DR   OMA; REQPYHP; -.
DR   OrthoDB; EOG091G0DTH; -.
DR   TreeFam; TF105830; -.
DR   Proteomes; UP000000437; Chromosome 8.
DR   Bgee; ENSDARG00000012929; -.
DR   GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR   GO; GO:0001731; P:formation of translation preinitiation complex; IBA:GO_Central.
DR   GO; GO:0002192; P:IRES-dependent translational initiation of linear mRNA; IBA:GO_Central.
DR   Gene3D; 1.10.245.10; -; 1.
DR   Gene3D; 2.30.130.10; -; 1.
DR   Gene3D; 3.30.780.10; -; 1.
DR   InterPro; IPR002478; PUA.
DR   InterPro; IPR015947; PUA-like_domain.
DR   InterPro; IPR036974; PUA_sf.
DR   InterPro; IPR001950; SUI1.
DR   InterPro; IPR036877; SUI1_dom_sf.
DR   InterPro; IPR036885; SWIB_MDM2_dom_sf.
DR   InterPro; IPR004521; Uncharacterised_CHP00451.
DR   Pfam; PF01472; PUA; 1.
DR   Pfam; PF01253; SUI1; 1.
DR   SMART; SM00359; PUA; 1.
DR   SUPFAM; SSF47592; SSF47592; 1.
DR   SUPFAM; SSF55159; SSF55159; 1.
DR   SUPFAM; SSF88697; SSF88697; 1.
DR   TIGRFAMs; TIGR00451; unchar_dom_2; 1.
DR   PROSITE; PS50890; PUA; 1.
DR   PROSITE; PS50296; SUI1; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:B0UYH2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT   DOMAIN       93    173       PUA. {ECO:0000259|PROSITE:PS50890}.
FT   DOMAIN      497    570       SUI1. {ECO:0000259|PROSITE:PS50296}.
SQ   SEQUENCE   590 AA;  66140 MW;  D30844D15E962D0E CRC64;
     MFAKAFRVKS NTVIKGSDRR KLRADISAAF PSLSVEELNE LVPNKEELNI VKIYAHKGDA
     VTLYVLHKNP IFFQLEKQLF PTVYTLWRCP NMLPAFTTWP PVLQKLSGGA DLMLPGVVLS
     TSGLPEVNRG ECCAVTLVMN RAPVAVGTAA MSSAEMRNSG MKGKGVNVLH TYMDQLWAFG
     DKTHPPVIPV TNSPTQVEGE EEGEECEEEE EEVKDSSENV AVETACQSLQ ELKLAENEVL
     KEESVEDKEG ENIDGEEGDS RSPQEQMDEL LLQCFLHALK TKVKKSELPL LTSTFLRNHM
     VSCCPRGKQL DIKKSSYKKL SKFLQIMQRD HSLLQVKELS KGVESIVDVD WRNPELCSFK
     IPEDCALEKE FEEGDGACEV EYQPPEITPL YGVTARLEPL FQDAHKKKGT SLKATEVRNI
     ITEYVKKNEL VNEINKNYVI INPTLCDCLL EKSEYQEVEM LKWDDLISRT LIRMQACHEV
     LFPGQPPVVK KGQMEPIDIT VASRGSNKKV TVIKNLEAFG LDPAMVAEAL QHQVQASCVL
     HDCPGAKNRV LVQIQGNQVQ HVGKLLLDRY QIPRKYVQGL DKAPKPGKKK
//
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