ID B0VXV5_SISCA Unreviewed; 241 AA.
AC B0VXV5;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 24-JAN-2024, entry version 49.
DE SubName: Full=Nerve growth factor {ECO:0000313|EMBL:ABG26990.1};
OS Sistrurus catenatus edwardsii (Desert massasauga) (Crotalophorus
OS edwardsii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Viperidae; Crotalinae; Sistrurus.
OX NCBI_TaxID=8762 {ECO:0000313|EMBL:ABG26990.1};
RN [1] {ECO:0000313|EMBL:ABG26990.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Venom gland {ECO:0000313|EMBL:ABG26990.1};
RA Kini R.M., Mackessy S.P., Pahari S.;
RT "cDNA clones from a library of Sistrurus catenatus edwardsii venom gland.";
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ABG26990.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Venom gland {ECO:0000313|EMBL:ABG26990.1};
RX PubMed=18096037; DOI=10.1186/1471-2199-8-115;
RA Pahari S., Mackessy S.P., Kini R.M.;
RT "The venom gland transcriptome of the Desert Massasauga rattlesnake
RT (Sistrurus catenatus edwardsii): towards an understanding of venom
RT composition among advanced snakes (Superfamily Colubroidea).";
RL BMC Mol. Biol. 8:115-115(2007).
CC -!- SUBUNIT: Homodimer; non-covalently linked.
CC {ECO:0000256|ARBA:ARBA00011804}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the NGF-beta family.
CC {ECO:0000256|ARBA:ARBA00010783}.
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DR EMBL; DQ464261; ABG26990.1; -; mRNA.
DR AlphaFoldDB; B0VXV5; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0008191; F:metalloendopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR020425; Nerve_growth_factor_bsu.
DR InterPro; IPR045815; NTF3_N.
DR InterPro; IPR020433; Venom_nerve_growth_factor.
DR PANTHER; PTHR11589:SF10; BETA-NERVE GROWTH FACTOR; 1.
DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR Pfam; PF00243; NGF; 1.
DR Pfam; PF19338; NTF3_N; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR00268; NGF.
DR PRINTS; PR01913; NGFBETA.
DR PRINTS; PR01917; VENOMNGF.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR001789-1};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Metalloenzyme inhibitor {ECO:0000256|ARBA:ARBA00023215};
KW Metalloprotease inhibitor {ECO:0000256|ARBA:ARBA00022608};
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..241
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002755442"
FT DOMAIN 128..232
FT /note="Nerve growth factor-related"
FT /evidence="ECO:0000259|SMART:SM00140"
FT DISULFID 136..201
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT DISULFID 179..229
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT DISULFID 189..231
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
SQ SEQUENCE 241 AA; 26777 MW; 05C5818127E1A464 CRC64;
MSMLCYTLII AFLIGIWAAP KSEDNVPLGS PATSDLSDTS CAKTHEALKT SRNTDQHYPA
PKKAEDQEFV SAANIIVDPK LFQKRRFQSP RVLFSTQPPP LSRDEQSVDN ANSLNRNIRA
KREDHPVHNR GEYSVCDSVN VWVANKTTAT DIRGNLVTGM GNVNINNNVY KQYFFETKCK
NPTQYQLGCG ALNARHGNSY CTTTNTFARA LTMGGNQASW RFIRIDSACV CVISRKNGNH
G
//
