ID B0VZD0_CULQU Unreviewed; 587 AA.
AC B0VZD0;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 93.
DE RecName: Full=Ceramide transfer protein {ECO:0000256|ARBA:ARBA00021440};
DE AltName: Full=Collagen type IV alpha-3-binding protein {ECO:0000256|ARBA:ARBA00031527};
GN Name=6030881 {ECO:0000313|EnsemblMetazoa:CPIJ000088-PA};
GN ORFNames=CpipJ_CPIJ000088 {ECO:0000313|EMBL:EDS25711.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS25711.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS25711.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ000088-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ000088-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=N-hexadecanoylsphing-4-enine(in) = N-hexadecanoylsphing-4-
CC enine(out); Xref=Rhea:RHEA:45720, ChEBI:CHEBI:72959;
CC Evidence={ECO:0000256|ARBA:ARBA00000074};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00004240}. Golgi apparatus
CC {ECO:0000256|ARBA:ARBA00004555}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS231813; EDS25711.1; -; Genomic_DNA.
DR RefSeq; XP_001841758.1; XM_001841706.1.
DR AlphaFoldDB; B0VZD0; -.
DR STRING; 7176.B0VZD0; -.
DR EnsemblMetazoa; CPIJ000088-RA; CPIJ000088-PA; CPIJ000088.
DR GeneID; 6030881; -.
DR KEGG; cqu:CpipJ_CPIJ000088; -.
DR VEuPathDB; VectorBase:CPIJ000088; -.
DR VEuPathDB; VectorBase:CQUJHB007049; -.
DR eggNOG; KOG1739; Eukaryota.
DR HOGENOM; CLU_017289_0_0_1; -.
DR InParanoid; B0VZD0; -.
DR OMA; SLFWSHM; -.
DR OrthoDB; 5489052at2759; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR CDD; cd13283; PH_GPBP; 1.
DR CDD; cd08872; START_STARD11-like; 1.
DR Gene3D; 3.30.530.20; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR041952; STARD11_START.
DR InterPro; IPR023393; START-like_dom_sf.
DR InterPro; IPR002913; START_lipid-bd_dom.
DR PANTHER; PTHR19308:SF53; CERAMIDE TRANSFER PROTEIN; 1.
DR PANTHER; PTHR19308; PHOSPHATIDYLCHOLINE TRANSFER PROTEIN; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF01852; START; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00234; START; 1.
DR SUPFAM; SSF55961; Bet v1-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50848; START; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320}.
FT DOMAIN 25..119
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 376..572
FT /note="START"
FT /evidence="ECO:0000259|PROSITE:PS50848"
FT REGION 320..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 587 AA; 67739 MW; 5E32E88EAF2402AA CRC64;
MADEYYLQNN ASNSDDSESE LNLSIPELKG YLSKWTNYIH GWQPRFIVLK DGTLSYYKSE
QDSDFGCRGA ISLQKATIKS HEFDECRFDV SIGQNVWYLR AETPEDKRNW IEVLQSYKTD
YPETVSLRRH GSTISLQSNT LSTASGSSMK RVSRGLREKM HEIETYRDIL YGQIETLQRY
FDSLHLKSGE NNPLDLGDGL KPIDFKGEAI TFRETTAGVI TTLQHCLDII SQKEESFKKK
FDREVDRRKK AEDLYRQCKD EVMKNRNTSI PGPDLEEGPH STIPEDEFFD AVETGLDKIE
EDRQLRVRLK FQSQQSQIST TSSVFTANQE TDDDKQQSED FGTGVQARTH KLWPEIDRIC
TEQLDQARQG VGDGGNGWQL FADEGEMKMY RREEEVDGMV IDPLKSCHVV QGVTAREMCH
YFFDPAYRND WETTLEDVQL VDNVAPDTMV FLQTYKRIWP ASQRDALFWS HMRKISDNED
QSAHDTWVVC NHSNQNEEYP PANQGKCVRI YLTVILLCQT YLPPGKDAKT ATRDDLTCKI
TYCSTVNPGG WAPATVLRAI YKKEYPKFLK RFTGYVIEQS KNKPIMY
//
