ID B0VZV7_CULQU Unreviewed; 496 AA.
AC B0VZV7;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 24-JAN-2024, entry version 84.
DE RecName: Full=UDP-glucuronosyltransferase {ECO:0000256|RuleBase:RU362059};
DE EC=2.4.1.17 {ECO:0000256|RuleBase:RU362059};
GN Name=6031148 {ECO:0000313|EnsemblMetazoa:CPIJ000226-PA};
GN ORFNames=CpipJ_CPIJ000226 {ECO:0000313|EMBL:EDS35199.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS35199.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS35199.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ000226-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ000226-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor
CC beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223,
CC ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17;
CC Evidence={ECO:0000256|RuleBase:RU362059};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU362059}; Single-
CC pass membrane protein {ECO:0000256|RuleBase:RU362059}.
CC -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC {ECO:0000256|ARBA:ARBA00009995, ECO:0000256|RuleBase:RU003718}.
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DR EMBL; DS231815; EDS35199.1; -; Genomic_DNA.
DR RefSeq; XP_001841991.1; XM_001841939.1.
DR AlphaFoldDB; B0VZV7; -.
DR SMR; B0VZV7; -.
DR EnsemblMetazoa; CPIJ000226-RA; CPIJ000226-PA; CPIJ000226.
DR KEGG; cqu:CpipJ_CPIJ000226; -.
DR VEuPathDB; VectorBase:CPIJ000226; -.
DR VEuPathDB; VectorBase:CQUJHB005363; -.
DR eggNOG; KOG1192; Eukaryota.
DR HOGENOM; CLU_012949_0_2_1; -.
DR InParanoid; B0VZV7; -.
DR OMA; GAMSKND; -.
DR OrthoDB; 382054at2759; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015020; F:glucuronosyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd03784; GT1_Gtf-like; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR InterPro; IPR002213; UDP_glucos_trans.
DR InterPro; IPR035595; UDP_glycos_trans_CS.
DR PANTHER; PTHR48043; EG:EG0003.4 PROTEIN-RELATED; 1.
DR PANTHER; PTHR48043:SF145; EG:EG0003.4 PROTEIN-RELATED; 1.
DR Pfam; PF00201; UDPGT; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
DR PROSITE; PS00375; UDPGT; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW ECO:0000256|RuleBase:RU003718};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW Signal {ECO:0000256|RuleBase:RU362059};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003718}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|RuleBase:RU362059"
FT CHAIN 28..496
FT /note="UDP-glucuronosyltransferase"
FT /evidence="ECO:0000256|RuleBase:RU362059"
FT /id="PRO_5011325914"
SQ SEQUENCE 496 AA; 55499 MW; 0A64F2664CF324EF CRC64;
MGSTTRLLTL LFLVTTTSVI LLNGADSARI LCVFPTASKS HVLGMQALMK NLAKRGHEIT
MVSAFPLSKP VQNYRDVYVP IEGAFGPLMA NFMQGKDRNM LKVMPVIVAA SLEYTNATLN
SPQFRRLVDE ERFDLAVVGW FMNDYVAGIG QLFKCPTVLY FSAGFSSMVN FFGNPTEVAA
VPHMLLGNKN PMGFLDRLQN TMIYGVDAAI GQYLRYKTKP YYDYNFPEER GFLPYDEAKR
HVSLVIFNSY FTQAVPRPYL PNVIEVGGLQ IKPKPDPLPA DIQAWLDGAE HGAIFLSFGS
NLKSSNLRQD KFDAILAALS KLKQRIIWKW DTDVMPGKPA NVMIGQWLPQ DDILAHKNLV
LFVTHCGLGS VTESMYHGVP IVGIPMFGDQ EHNAAQVLKE GWGEVVTFED LTEETLSSAI
RGVLGNEQYR QTVQKMADLY RDRPQTGLDL ATFWLEYVVR HKGAPHLHYQ GADLNFLQRN
LVDVFAAIGA VLSFKR
//
