ID B0W1R4_CULQU Unreviewed; 321 AA.
AC B0W1R4;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE SubName: Full=Transforming protein Ski {ECO:0000313|EMBL:EDS26615.1, ECO:0000313|EnsemblMetazoa:CPIJ000978-PA};
GN Name=6031975 {ECO:0000313|EnsemblMetazoa:CPIJ000978-PA};
GN ORFNames=CpipJ_CPIJ000978 {ECO:0000313|EMBL:EDS26615.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS26615.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS26615.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ000978-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ000978-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SKI family. {ECO:0000256|ARBA:ARBA00009513}.
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DR EMBL; DS231823; EDS26615.1; -; Genomic_DNA.
DR RefSeq; XP_001842648.1; XM_001842596.1.
DR AlphaFoldDB; B0W1R4; -.
DR STRING; 7176.B0W1R4; -.
DR EnsemblMetazoa; CPIJ000978-RA; CPIJ000978-PA; CPIJ000978.
DR KEGG; cqu:CpipJ_CPIJ000978; -.
DR VEuPathDB; VectorBase:CPIJ000978; -.
DR VEuPathDB; VectorBase:CQUJHB015905; -.
DR eggNOG; ENOG502QTF6; Eukaryota.
DR HOGENOM; CLU_030459_0_0_1; -.
DR InParanoid; B0W1R4; -.
DR OMA; DLHHECS; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0046332; F:SMAD binding; IEA:InterPro.
DR CDD; cd21079; DHD_Ski_Sno; 1.
DR Gene3D; 3.10.390.10; SAND domain-like; 1.
DR Gene3D; 3.10.260.20; Ski; 1.
DR InterPro; IPR014890; c-SKI_SMAD4-bd_dom.
DR InterPro; IPR009061; DNA-bd_dom_put_sf.
DR InterPro; IPR010919; SAND-like_dom_sf.
DR InterPro; IPR003380; SKI/SNO/DAC.
DR InterPro; IPR037000; Ski_DNA-bd_sf.
DR InterPro; IPR023216; Tscrpt_reg_SKI_SnoN.
DR PANTHER; PTHR10005; SKI ONCOGENE-RELATED; 1.
DR PANTHER; PTHR10005:SF25; SNO ONCOGENE, ISOFORM B; 1.
DR Pfam; PF08782; c-SKI_SMAD_bind; 1.
DR Pfam; PF02437; Ski_Sno; 1.
DR SMART; SM01046; c-SKI_SMAD_bind; 1.
DR SUPFAM; SSF46955; Putative DNA-binding domain; 1.
DR SUPFAM; SSF63763; SAND domain-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002320}.
FT DOMAIN 199..291
FT /note="c-SKI SMAD4-binding"
FT /evidence="ECO:0000259|SMART:SM01046"
FT REGION 24..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 321 AA; 36180 MW; 4461A016FAA2766E CRC64;
MTEYVPPQLI TVLKTYQDNA PKGLHGPGLS LVHPSKSGGA GPPRPETPES HHVGSGAGLV
TTENGLIVQP ITGPLPMPSH PIMTTPDPDC GVVQLTTLEG KKIGCFLLGG EMRLCLPQIF
NNILMEFSVE QINRSIQELM IYLYNCTDQQ LQEFKRANII PDTAKTCGLI TRTNAERLCS
YMLHQADQIR PRKGTTLTSF RVYHKCFGKC EGIFTVELYS YKEPACIECC ECQGMFSPQK
FVCHQHDRQE NRTCHWGFNS SNWCAYIHVA LDEDNREAFA KILEEIWSGE RETETEQEYW
IAKQKVGLIF ARNSIYCPGF I
//
