ID B0W3L8_CULQU Unreviewed; 1768 AA.
AC B0W3L8;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 97.
DE SubName: Full=Voltage-gated ion channel {ECO:0000313|EMBL:EDS31804.1, ECO:0000313|EnsemblMetazoa:CPIJ001404-PA};
GN Name=6032761 {ECO:0000313|EnsemblMetazoa:CPIJ001404-PA};
GN ORFNames=CpipJ_CPIJ001404 {ECO:0000313|EMBL:EDS31804.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS31804.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS31804.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ001404-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ001404-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EMBL; DS231832; EDS31804.1; -; Genomic_DNA.
DR RefSeq; XP_001843302.1; XM_001843250.1.
DR STRING; 7176.B0W3L8; -.
DR EnsemblMetazoa; CPIJ001404-RA; CPIJ001404-PA; CPIJ001404.
DR KEGG; cqu:CpipJ_CPIJ001404; -.
DR VEuPathDB; VectorBase:CPIJ001404; -.
DR VEuPathDB; VectorBase:CQUJHB006450; -.
DR eggNOG; KOG2301; Eukaryota.
DR HOGENOM; CLU_000984_0_0_1; -.
DR InParanoid; B0W3L8; -.
DR OMA; TLFIAWN; -.
DR OrthoDB; 1110761at2759; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005261; F:monoatomic cation channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR028823; NALCN.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR46141:SF1; SODIUM LEAK CHANNEL NALCN; 1.
DR PANTHER; PTHR46141; SODIUM LEAK CHANNEL NON-SELECTIVE PROTEIN; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 68..91
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 111..131
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 177..199
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 295..318
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 384..404
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 416..439
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 451..475
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 507..530
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 574..597
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 891..915
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 935..954
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 966..984
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1027..1046
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1143..1166
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1224..1241
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1247..1266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1309..1325
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1345..1366
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1432..1454
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 38..328
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 380..601
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 897..1172
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1220..1465
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 1638..1706
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1638..1658
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1659..1675
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1768 AA; 204317 MW; 8E10D95132081ED9 CRC64;
MLGRKQSIKG ESVLADYGPE ESLNESADIE WVNKLWVRRL MRLCALVSLT SVSLNTPKTF
ERYPMLQYIT LCSDIVVTLL FTSEMIAKIH IRGLIKGEAP YLKDHWCQFD ASMVSFLWVS
VVLHIFEMLA IVPKFHYFTI LRAPRPLIMI RFLRVFLKFS MPKSRINQIF KRSSQQIYNV
TLFFLFFMSL YGLLGVQFFG ELKNHCVLNT TDPEGLTINS LAIPDTFCSM DPDSGYQCPT
GMKCMKMHFL TNYVQGFTGF EDIATSIFTV YQAASQEGWV FIMYRAIDSL PAWRAAFYFS
TMIFFLAWLV KNVFIAVITE TFNEIRVQFQ QMWGVRGHIQ NSAASQVITG DDSGWKLITI
DENKHGGLAN ETCHLILKSP YFRLLVMSTI LANGIVTATM HFKHDGRPRQ VFYERYYYIE
MAFTVLLDLE TLFKIYCLGW RGYFKHSIHK FELLLAIGTS LHIIPGLYLS GFTYFQVLRV
VRLIKASPML EGFVYKIFGP GKKLGSLIIF TMCLLIISSS ISMQLFCFLC DYTKFESFPD
AFMSMFQILT QEAWVEVMDE TMIRTSKTLT PLVAVYFILY HLFVTLIVLS LFVAVILDNL
ELDEDIKKLK QLKFREQSAE IKETLPFRLR IFEKFPDSPQ MTILHKIPND FTLPKVRESF
MKQFVIDMEP EDPSYCEGYK RPMSECWESK VVYRKQKPVN VMNKTAKVRC VGSSLRKLAI
THIINDSNNQ RLMLGDSAMI PVAGVKSGIK QQGTITQTKP WRMDQKKFGS RSIRRSVRSG
SIKLKQTYEH LMENGDIGAA SRVTSSRARP HDLDIKILQA KRQQAEMRRN QREEDLRENH
PFFDTPLFAV PRESKFRKIC QRIVHGRYDA RLKDPLTGKE RKVQYKSMHN FLGLVTYLDW
VMIFVTTLSC NSMIFETPQY RVMEHVTLQI AEYTFVIFMS LELALKILAD GLFFTPKAYI
KDVASVLDVF IYVVSLTFLV WMPRQVPSNS SAQLLMILRC LRPLRIFTLV PHMRKVVYEL
CRGFKEILLV STLLILLMFV FASYGVQLYG GRLARCNDPT ILKREDCVGV FMRRVFVTKM
KLTPGVNESY PAMLVPRVWA NPRRFNFDNI GDAMLALFEV LSYKGWIDVR DVLIKALGPV
HAIYIHVYIF LGCMIGLTLF VGVVIANYSE NKGTALLTVD QRRWCDLKKR LKIAQPLHLP
PRPDGRKFRA FVYDITQHIA FKRCIAVVVL VNSMLLSITW QKDEVHTARL VIVSTLLTFV
FVIEVVMKNI AFTPRGYWQS RRNRYDLLVT VAGVVWIFLQ TTLRSDLSLF IGFMVVILRF
FTITGKHTTL KMLMLTVGVS VCKSFFIIFG MFLLVFFYAL AGTILFGTVK YGEGIGRRAN
FGSPVTGVAM LFRIVTGEDW NKIMHDCMVQ PPYCTLAANY WETDCGNFTA SLIYFCTFYV
IITYIVLNLL VAIIMENFSL FYSNEEDALL SYADIRNFQN TWNIVDIHQR GVIPVRRVKF
ILRLLKGRLE CDPQKDRLLF KYMCYELDKL HNGEDVTFHD VINMLSYRSV DIRKALQLEE
LLAREEFEYI IEEEVAKQTI RTWLEGCLKK IRANNVTRQQ NSLIAGLRAE NIQRQQQQQQ
EAADELALNK EVSLEPDTVE LPVKEVEHNA KGRKKSQNLN RSDSTGSSSG RKFLAPTLSD
PQAKNEKDRY ISKKKSQRQS GTNTKNITQI NELNHGHTLH QHYHHIAHGS EMQQTSNSKV
GHPHISMVYE VHDWWQEQVT CPHSEDEE
//
