ID   B0W6G4_CULQU            Unreviewed;       386 AA.
AC   B0W6G4;
DT   08-APR-2008, integrated into UniProtKB/TrEMBL.
DT   08-APR-2008, sequence version 1.
DT   27-MAR-2024, entry version 78.
DE   RecName: Full=Lipase {ECO:0000256|PIRNR:PIRNR000862};
GN   Name=6033909 {ECO:0000313|EnsemblMetazoa:CPIJ002715-PA};
GN   ORFNames=CpipJ_CPIJ002715 {ECO:0000313|EMBL:EDS36638.1};
OS   Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Culicini; Culex; Culex.
OX   NCBI_TaxID=7176;
RN   [1] {ECO:0000313|EMBL:EDS36638.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHB {ECO:0000313|EMBL:EDS36638.1};
RG   The Broad Institute Genome Sequencing Platform;
RA   Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA   Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA   Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA   Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA   Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA   Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA   Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA   Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT   "Annotation of Culex pipiens quinquefasciatus.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:CPIJ002715-PA}
RP   IDENTIFICATION.
RC   STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ002715-PA};
RG   EnsemblMetazoa;
RL   Submitted (FEB-2021) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC       {ECO:0000256|ARBA:ARBA00010701, ECO:0000256|PIRNR:PIRNR000862}.
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DR   EMBL; DS231848; EDS36638.1; -; Genomic_DNA.
DR   RefSeq; XP_001844298.1; XM_001844246.1.
DR   AlphaFoldDB; B0W6G4; -.
DR   STRING; 7176.B0W6G4; -.
DR   ESTHER; culqu-b0w6g4; Acidic_Lipase.
DR   EnsemblMetazoa; CPIJ002715-RA; CPIJ002715-PA; CPIJ002715.
DR   GeneID; 6033909; -.
DR   KEGG; cqu:CpipJ_CPIJ002715; -.
DR   VEuPathDB; VectorBase:CPIJ002715; -.
DR   VEuPathDB; VectorBase:CQUJHB010154; -.
DR   eggNOG; KOG2624; Eukaryota.
DR   HOGENOM; CLU_010974_0_3_1; -.
DR   InParanoid; B0W6G4; -.
DR   OMA; LCVFINR; -.
DR   OrthoDB; 3259424at2759; -.
DR   Proteomes; UP000002320; Unassembled WGS sequence.
DR   GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR006693; AB_hydrolase_lipase.
DR   InterPro; IPR025483; Lipase_euk.
DR   PANTHER; PTHR11005:SF100; LIPASE-RELATED; 1.
DR   PANTHER; PTHR11005; LYSOSOMAL ACID LIPASE-RELATED; 1.
DR   Pfam; PF04083; Abhydro_lipase; 1.
DR   PIRSF; PIRSF000862; Steryl_ester_lip; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR000862};
KW   Lipid degradation {ECO:0000256|PIRNR:PIRNR000862};
KW   Lipid metabolism {ECO:0000256|PIRNR:PIRNR000862};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..386
FT                   /note="Lipase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5011407537"
FT   DOMAIN          20..75
FT                   /note="Partial AB-hydrolase lipase"
FT                   /evidence="ECO:0000259|Pfam:PF04083"
FT   ACT_SITE        153
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000862-1"
FT   ACT_SITE        327
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000862-1"
FT   ACT_SITE        358
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000862-1"
SQ   SEQUENCE   386 AA;  42796 MW;  5248F8CC80421CAE CRC64;
     MILLRILLVV FCIGTTFATV DLISAEGYTV EQHETVTSDG YVLTMFRIPG TPGNSSRPVV
     FLQHGLLCSS TDWLVLGAGH SLAYLFADAG YDVWLGNARG NTHSRRHVAL DPARDETFWD
     FSWHQIGLYD LPAMVDYALQ VTGESALHYV GHSQGTTAFF VMTSLRPEYN GKIRSMQALA
     PVAFMGHLQS PFLRVLAPFV DQIEWITGML GANEFLPSNS MLALGGQKFC QDTSPVVELC
     ANTLFLIGGF NSAQLNRSSL PVILANTPAG ASVKQLVHYA HNINSGSFRQ FDYGWALNLV
     RYGSILPPKY PLDRVTAPVL LHYGENDWLA AISDVHLLAR ELGNLVAILP VSDRKWNHLD
     FTYAVDAKIR LYEKVIDIVE QYENLT
//