ID B0W6Z7_CULQU Unreviewed; 1046 AA.
AC B0W6Z7;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE RecName: Full=Transcription elongation factor SPT5 {ECO:0000256|ARBA:ARBA00020181, ECO:0000256|PIRNR:PIRNR036945};
GN ORFNames=CpipJ_CPIJ003095 {ECO:0000313|EMBL:EDS37271.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS37271.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS37271.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR036945}.
CC -!- SIMILARITY: Belongs to the SPT5 family. {ECO:0000256|ARBA:ARBA00006956,
CC ECO:0000256|PIRNR:PIRNR036945}.
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DR EMBL; DS231851; EDS37271.1; -; Genomic_DNA.
DR RefSeq; XP_001844481.1; XM_001844429.1.
DR AlphaFoldDB; B0W6Z7; -.
DR STRING; 7176.B0W6Z7; -.
DR GeneID; 6034112; -.
DR KEGG; cqu:CpipJ_CPIJ003095; -.
DR VEuPathDB; VectorBase:CPIJ003095; -.
DR VEuPathDB; VectorBase:CQUJHB005192; -.
DR eggNOG; KOG1999; Eukaryota.
DR HOGENOM; CLU_003537_0_0_1; -.
DR InParanoid; B0W6Z7; -.
DR OMA; PYPVGYM; -.
DR OrthoDB; 24955at2759; -.
DR PhylomeDB; B0W6Z7; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0032784; P:regulation of DNA-templated transcription elongation; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR GO; GO:0140673; P:transcription elongation-coupled chromatin remodeling; IEA:InterPro.
DR CDD; cd06081; KOW_Spt5_1; 1.
DR CDD; cd06082; KOW_Spt5_2; 1.
DR CDD; cd06083; KOW_Spt5_3; 1.
DR CDD; cd06084; KOW_Spt5_4; 1.
DR CDD; cd06085; KOW_Spt5_5; 1.
DR CDD; cd06086; KOW_Spt5_6; 1.
DR CDD; cd09888; NGN_Euk; 1.
DR Gene3D; 2.30.30.30; -; 3.
DR Gene3D; 3.30.70.940; NusG, N-terminal domain; 1.
DR InterPro; IPR005824; KOW.
DR InterPro; IPR041973; KOW_Spt5_1.
DR InterPro; IPR041975; KOW_Spt5_2.
DR InterPro; IPR041976; KOW_Spt5_3.
DR InterPro; IPR041977; KOW_Spt5_4.
DR InterPro; IPR041978; KOW_Spt5_5.
DR InterPro; IPR041980; KOW_Spt5_6.
DR InterPro; IPR005100; NGN-domain.
DR InterPro; IPR006645; NGN-like_dom.
DR InterPro; IPR036735; NGN_dom_sf.
DR InterPro; IPR039385; NGN_Euk.
DR InterPro; IPR014722; Rib_uL2_dom2.
DR InterPro; IPR039659; SPT5.
DR InterPro; IPR024945; Spt5_C_dom.
DR InterPro; IPR022581; Spt5_N.
DR InterPro; IPR017071; TF_Spt5_eukaryote.
DR InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR PANTHER; PTHR11125; SUPPRESSOR OF TY 5; 1.
DR PANTHER; PTHR11125:SF7; TRANSCRIPTION ELONGATION FACTOR SPT5; 1.
DR Pfam; PF00467; KOW; 1.
DR Pfam; PF03439; Spt5-NGN; 1.
DR Pfam; PF11942; Spt5_N; 1.
DR PIRSF; PIRSF036945; Spt5; 1.
DR SMART; SM01104; CTD; 1.
DR SMART; SM00739; KOW; 5.
DR SMART; SM00738; NGN; 1.
DR SUPFAM; SSF50104; Translation proteins SH3-like domain; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR036945};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR036945}.
FT DOMAIN 179..270
FT /note="NusG-like N-terminal"
FT /evidence="ECO:0000259|SMART:SM00738"
FT DOMAIN 275..302
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 426..453
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 478..505
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 600..627
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 708..735
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 783..897
FT /note="Spt5 C-terminal"
FT /evidence="ECO:0000259|SMART:SM01104"
FT REGION 1..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 325..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 679..707
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 760..930
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..39
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..64
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..101
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 762..821
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 859..887
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 897..911
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1046 AA; 116028 MW; 436724F73B7D5B89 CRC64;
MTLDSGGSAR SRSGSGSRSG SDVEQIRMKK KRKISAGSDE EDAEEEQEPE GEDLDSEEIE
DDEDDDRRGG RKKKKKERFG GFIIDEAEVD DEVDEDDEWE EGAQDIGIVP NEVEEFGQTA
REIENRRRGT NLWDNKEDEI EEYLRKKYAD ESGRKHFGDG GEEMTDEIDQ QRRLPGIKDP
NLWMVKCRIG EEKATVLLLM RKFLTYSNTD EPLQIKSVVA PEGVKGYVYI EAYKQTHVKA
AITNVGNLRM GIWKQEMVPI KEMTDILKVV KEQTGLKPKQ WVRLKRGIYK DDIAQVDYVD
LAQNQVHLKL LPRIDYTRLR GALRTTSSEN DENKKKKKRR PAAKPFDPEA IRAIGGEVTS
DGDFLIFEGN RYSRKGFLYK NFTMSAILAE GVKPTLAELE RFEEQPEEIN IELAVSSKED
TNSTHTFSMG DNVEVCVGDL ENLQAKIIAI DGALITVMPK HEDLKDPLIF KASELRKYFK
TGDHAKVLAG RYEGETGLIV RVEPQRIVLV SDLTMHELEV LPRDLQLCSD MATGVDSLGQ
YQWGDLVQLD AQTVGVIVRL ERENFHVLGM HGKVMECKPT ALQKRRENRN TIALDSDQNQ
IRRRDIVKVM EGPHAGRDGE IKHLYRNLAF LHSRMYTENG GIFVCKTRHL QLAGGNKTQG
NALMPMGQFG FMSPRIHSPM HPSGGRGGAR GGGRGGGRGG ANRVSRDKEI LGKSIKITGG
PYKGAVGIVK DATESTARVE LHSSCQTISV DRNHIAVVGS TPKEGSVSSY IRTPSRTPSG
SYGAQTPVYS GSKTPLHGSQ TPSYDVGNRT PYGSMTPSHD GSMTPRHGAW DPAVTNTPAR
SNDFDFNMEE PSPSPGYNPS TPGYQINTPF APHTPGNMFN TENYSPYQPS PSPSPSPYQV
NYMGTPSPSG YSPATPGAPQ SPYNPQTPGA SLDSQFGEWC TTDIEVEIRN HDDSDLAGQT
GFIRTVTSGA CSVFLPEEDR VVTVLSNNLE PVVPTVAGDR FKVIFGDERE TLGEFLSLSS
NKEAIVSING KKKLLPLNYL CKVKLD
//
