ID B0W7H6_CULQU Unreviewed; 686 AA.
AC B0W7H6;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 110.
DE SubName: Full=Mitochondrial solute carrier {ECO:0000313|EMBL:EDS38011.1, ECO:0000313|EnsemblMetazoa:CPIJ002591-PA};
GN Name=6034328 {ECO:0000313|EnsemblMetazoa:CPIJ002591-PA};
GN ORFNames=CpipJ_CPIJ002591 {ECO:0000313|EMBL:EDS38011.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS38011.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS38011.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ002591-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ002591-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- SUBUNIT: Homodimer (via N-terminus). {ECO:0000256|ARBA:ARBA00038674}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004448}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000256|ARBA:ARBA00006375}.
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DR EMBL; DS231854; EDS38011.1; -; Genomic_DNA.
DR RefSeq; XP_001844660.1; XM_001844608.1.
DR AlphaFoldDB; B0W7H6; -.
DR STRING; 7176.B0W7H6; -.
DR EnsemblMetazoa; CPIJ002591-RA; CPIJ002591-PA; CPIJ002591.
DR GeneID; 6034328; -.
DR KEGG; cqu:CpipJ_CPIJ002591; -.
DR VEuPathDB; VectorBase:CPIJ002591; -.
DR VEuPathDB; VectorBase:CQUJHB007867; -.
DR eggNOG; KOG0751; Eukaryota.
DR HOGENOM; CLU_014931_3_0_1; -.
DR InParanoid; B0W7H6; -.
DR OMA; GPDAIPF; -.
DR OrthoDB; 1220009at2759; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0043490; P:malate-aspartate shuttle; IEA:UniProt.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR PANTHER; PTHR45678:SF9; CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN ARALAR1; 1.
DR PANTHER; PTHR45678; MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED; 1.
DR Pfam; PF00036; EF-hand_1; 1.
DR Pfam; PF13202; EF-hand_5; 1.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SMART; SM00054; EFh; 3.
DR SUPFAM; SSF47473; EF-hand; 2.
DR SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 100..135
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 171..206
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REPEAT 335..426
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 434..518
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 526..614
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
SQ SEQUENCE 686 AA; 75550 MW; F45C6DF1A6B76FD4 CRC64;
MKALTLEQIL NLCGVVAYCQ ENPMQIKRAS TDKLREIFAR YATQQINGEL FMTSEEFVRG
FLGQSYNEES VKLLAGIADT SKDGLISFAE FQAFEGLLCT PDALYKTAFQ LFDRNGNGSV
TYSEFVDVFK KTDLHAKIPF KLDGPFIQLY FGKDRQRTIS YAEFSQFLHD FHEECALEAF
RMKDTSGSGF ISALDFQDIM VNVKRHLLTA EVKDNLVAVT EGHRVSFPYF MAFNSLLNNM
ELIKRIYLNA TAGSRTEPVT KDELLHSAQT MSQITPLEID ILYQLTGAVH QTGRLVYSDL
SSIAPEHYTK HITHRLAEIK AVESPADRSI FIQLLESTYR FTLGSVAGAV GATAVYPIDL
VKTRMQNQRT GSFIGEVAYR NSWDCCKKVI RHEGALGLYR GLVPQLMGVA PEKAIKLTVN
DLVRDKMTDK QGQIPRWAEV LAGGCAGGSQ VIFTNPLEIV KIRLQVAGEI AGGAKVRAWN
VVRELGLFGL YKGARACLLR DVPFSAIYFP MYAHVKAAFA DEQGYNHPLT LLAAGAIAGI
PAASLVTPAD VIKTRLQVVA RTGQTTYNGV MDAARKIMAE EGPRAFWKGT VARVFRSSPQ
FGVTLVTYEL LQRLLYVDFG GSRPAGSDVA HTGKPAELTK LNPDHIGGYQ AALPMLNGIE
TKFGLSLPRF ASTIKVPGAG QVPASS
//
