ID B0W8F7_CULQU Unreviewed; 397 AA.
AC B0W8F7;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 93.
DE RecName: Full=Alanine--glyoxylate aminotransferase {ECO:0000256|PIRNR:PIRNR000524};
DE EC=2.6.1.44 {ECO:0000256|PIRNR:PIRNR000524};
GN Name=6034710 {ECO:0000313|EnsemblMetazoa:CPIJ002835-PA};
GN ORFNames=CpipJ_CPIJ002835 {ECO:0000313|EMBL:EDS38886.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS38886.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS38886.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ002835-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ002835-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glyoxylate + L-alanine = glycine + pyruvate;
CC Xref=Rhea:RHEA:24248, ChEBI:CHEBI:15361, ChEBI:CHEBI:36655,
CC ChEBI:CHEBI:57305, ChEBI:CHEBI:57972; EC=2.6.1.44;
CC Evidence={ECO:0000256|PIRNR:PIRNR000524};
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|PIRNR:PIRNR000524, ECO:0000256|PIRSR:PIRSR000524-50};
CC -!- SIMILARITY: Belongs to the class-V pyridoxal-phosphate-dependent
CC aminotransferase family. {ECO:0000256|ARBA:ARBA00009236,
CC ECO:0000256|PIRNR:PIRNR000524}.
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DR EMBL; DS231858; EDS38886.1; -; Genomic_DNA.
DR RefSeq; XP_001844991.1; XM_001844939.1.
DR AlphaFoldDB; B0W8F7; -.
DR STRING; 7176.B0W8F7; -.
DR EnsemblMetazoa; CPIJ002835-RA; CPIJ002835-PA; CPIJ002835.
DR KEGG; cqu:CpipJ_CPIJ002835; -.
DR VEuPathDB; VectorBase:CPIJ002835; -.
DR VEuPathDB; VectorBase:CQUJHB008569; -.
DR eggNOG; KOG2862; Eukaryota.
DR HOGENOM; CLU_027686_0_0_1; -.
DR InParanoid; B0W8F7; -.
DR OMA; NHTGPRA; -.
DR OrthoDB; 1010571at2759; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0008453; F:alanine-glyoxylate transaminase activity; IEA:UniProtKB-EC.
DR CDD; cd06451; AGAT_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR000192; Aminotrans_V_dom.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR InterPro; IPR024169; SP_NH2Trfase/AEP_transaminase.
DR PANTHER; PTHR21152:SF39; ALANINE--GLYOXYLATE AMINOTRANSFERASE; 1.
DR PANTHER; PTHR21152; AMINOTRANSFERASE CLASS V; 1.
DR Pfam; PF00266; Aminotran_5; 1.
DR PIRSF; PIRSF000524; SPT; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 3: Inferred from homology;
KW Aminotransferase {ECO:0000313|EMBL:EDS38886.1};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRNR:PIRNR000524}; Pyruvate {ECO:0000313|EMBL:EDS38886.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW Transferase {ECO:0000313|EMBL:EDS38886.1}.
FT DOMAIN 37..334
FT /note="Aminotransferase class V"
FT /evidence="ECO:0000259|Pfam:PF00266"
FT BINDING 354
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000524-1"
FT MOD_RES 205
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR000524-50"
SQ SEQUENCE 397 AA; 44584 MW; AA244C682D49630C CRC64;
MDTITPPVSL LKPMNIPEKI MMGPGPSNCS KRVLTALTNT SLSNFHAELF QVIDEVKDGI
RYVFQTRNRT TMCISGSAHA AMEALLCNLL EEGERVLIAV NGIWAERAVE MATRYGADVR
ILEGPDDKPF PLADLKKAIE QHKPKCLFVT HGDSSSGLLQ PLEELGRVCH ENDCLLLVDA
VASLCGVPFY MDKWEIDGVY TGSQKVLGAP PGITPISISD KALAAIRARK TKSKVFYWDL
LLLGNYWGCY DEQKMYHHTV SSNLIFALRE ALAQIVEEGL DAQIQRRQEC ARALYRGLSE
MGLEIFIKNP KHRLSTVTGI MIPEGVTWWK VSQYAMKNLE IQGGLGPTWE KAWRVGIMGE
CSTLQKVNYY LFAFRESLKA THPEYEFVEL KHQNGYH
//
