GenomeNet

Database: UniProt
Entry: B0WD49_CULQU
LinkDB: B0WD49_CULQU
Original site: B0WD49_CULQU 
ID   B0WD49_CULQU            Unreviewed;      1200 AA.
AC   B0WD49;
DT   08-APR-2008, integrated into UniProtKB/TrEMBL.
DT   08-APR-2008, sequence version 1.
DT   27-SEP-2017, entry version 66.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=6036601 {ECO:0000313|VectorBase:CPIJ004992-PA};
GN   ORFNames=CpipJ_CPIJ004992 {ECO:0000313|EMBL:EDS44184.1};
OS   Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Culicinae; Culicini; Culex; Culex.
OX   NCBI_TaxID=7176 {ECO:0000313|Proteomes:UP000002320};
RN   [1] {ECO:0000313|Proteomes:UP000002320}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHB {ECO:0000313|Proteomes:UP000002320};
RG   The Broad Institute Genome Sequencing Platform;
RA   Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.D.,
RA   Hannick L.I., Megy K., O'Leary S.B., Pearson M., Haas B.J.,
RA   Mauceli E., Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L.,
RA   Amedeo P., Antoine C.H., Arensburger P., Bidwell S.L., Crawford M.,
RA   Camaro F., Devon K., Engels R., Hammond M., Howarth C., Koehrsen M.,
RA   Lawson D., Montgomery P., Nene V., Nusbaum C., Puiu D.,
RA   Romero-Severson J., Severson D.W., Shumway M., Sisk P., Stolte C.,
RA   Zeng Q., Eisenstadt E., Fraser-Liggett C.M., Strausberg R.,
RA   Galagan J., Birren B., Collins F.H.;
RT   "Annotation of Culex pipiens quinquefasciatus.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EDS44184.1, ECO:0000313|VectorBase:CPIJ004992-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHB {ECO:0000313|EMBL:EDS44184.1,
RC   ECO:0000313|VectorBase:CPIJ004992-PA};
RG   The Broad Institute Genome Sequencing Platform;
RA   Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA   Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA   Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA   Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA   Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA   Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA   Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA   Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT   "Annotation of Culex pipiens quinquefasciatus.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|VectorBase:CPIJ004992-PA}
RP   IDENTIFICATION.
RC   STRAIN=JHB {ECO:0000313|VectorBase:CPIJ004992-PA};
RG   VectorBase;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; DS231893; EDS44184.1; -; Genomic_DNA.
DR   RefSeq; XP_001846633.1; XM_001846581.1.
DR   ProteinModelPortal; B0WD49; -.
DR   STRING; 7176.CPIJ004992-PA; -.
DR   EnsemblMetazoa; CPIJ004992-RA; CPIJ004992-PA; CPIJ004992.
DR   GeneID; 6036601; -.
DR   KEGG; cqu:CpipJ_CPIJ004992; -.
DR   VectorBase; CPIJ004992-RA; CPIJ004992-PA; CPIJ004992.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   HOGENOM; HOG000045209; -.
DR   InParanoid; B0WD49; -.
DR   KO; K21862; -.
DR   OMA; ICVESPK; -.
DR   OrthoDB; EOG091G01WJ; -.
DR   PhylomeDB; B0WD49; -.
DR   Proteomes; UP000002320; Partially assembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028820; Na_channel_60E.
DR   InterPro; IPR001696; Na_channel_asu.
DR   PANTHER; PTHR10037:SF257; PTHR10037:SF257; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 2.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002320};
KW   Ion channel {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000313|EMBL:EDS44184.1};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     87    108       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    114    136       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    168    194       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    286    310       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    372    392       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    398    419       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    431    450       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    473    501       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    569    593       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN       53    319       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      371    605       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      611    672       GPHH. {ECO:0000259|Pfam:PF16905}.
SQ   SEQUENCE   1200 AA;  135789 MW;  8A4EDBDD23351A23 CRC64;
     MIFVSRKKTT LVFFPAAAAA TPRCKCWDNC LKTDLGQRWY RFRQSTLQYV DTPAFEWFVL
     VLIFASSITL CFEDIHLDKN KRLKQILYWT NFVFCLIFVI EMLLKWVALG FTKYFSSFWT
     ILDFIIVFVS VFSLLIEENE NLKVLRSLRT LRALRPLRAI SRWQGMRIVV NALMYAIPSI
     FNVLLVCLVF WLIFSIMGVQ FFGGKFFKCV DEDGELLPIH IVNDKWQCFA QNYTWINSKI
     TFDHVGMGYL ALFQVATFEG WMEVMADAVD ARGVDLQPQR EANLYAYIYF VIFIVCGSFF
     TLNLFIGVII DNFNMLKKKY EGGVLEMFLT ESQKHYYTAM KKLGRKKPQK VIKRPINQFL
     AMFYDLSNSR RFEIAIFVLI FLNMLTMGIE HYDQPHAVFF VLEVSNAFFT TVFGLEAIVK
     IVGLRYHYFT VPWNVFDFLL VLASIFGILM EDIMIDLPIS PTLLRAAKGI RKLLFALVVS
     LPALFNIGAL LALITFIYAI IGMSLFGHVR QQGALDDMVN FETFGRSMQL LFRLMTSAGW
     NDVLESLMIQ PPDCNLAPDL SNGDCGHPLL AITYFTSFII ISYMIVINMY IAIILENFNQ
     AHQEEEIGIV EDDLEMFYIR WSKYDPHAGQ FIHFNQLSDF IASLDPPLGI PKPNTVALVS
     FNLPISKGNK IHCLDILHAL VKHVLGHVEE TDNFKQLQDQ MDQKFKKQFP TRKELEIVSS
     TRIWKRQEKA AKTIQTAWRE YLRLKKERER SPMSLEDENT QTSSPGGWQS KLSALNFLHL
     QVHRRGTATS SRASSRKSSR ASDASDLSEL AGPWLNLPLM LVSGTSDTAK DVKQMHANGQ
     ELKDSFEGKA GPRRRSFYNF PFFLGRQDAV EESNNSPQPQ KRPLKTSETD LSLPTSLDKT
     TPVASPTPPV KHKRATSFVK KKPPLERGFS AQSALRLNRN AAVADDTLSV STADVSILVT
     EPSPDVPTGP NLVKLPGGEA TLVHVLVHRE SEEYQSDVDE KDETKVKEPR DPSKASDIKI
     SPGTNVDYQI LGGCDEGPRP VVTICVESPK ESPDTPEQHQ LPSGGDTVIA MVDPEPIDVN
     LPRDTSNIFY DYEEPKEPKP AIIPPEVPPR AHVHPLQQQD LDKIEYDTAR MSSSTSSATS
     NCSSGSSTTS GADGDAPECP RKTGEDLRRY FLARPQPAGC VLSSTRVPVV AYRDTKTPTS
//
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