ID   B0WFH3_CULQU            Unreviewed;       446 AA.
AC   B0WFH3;
DT   08-APR-2008, integrated into UniProtKB/TrEMBL.
DT   08-APR-2008, sequence version 1.
DT   27-MAR-2024, entry version 77.
DE   SubName: Full=Methionine synthase reductase, mitochondrial {ECO:0000313|EMBL:EDS26241.1};
GN   Name=6037559 {ECO:0000313|EnsemblMetazoa:CPIJ006043-PA};
GN   ORFNames=CpipJ_CPIJ006043 {ECO:0000313|EMBL:EDS26241.1};
OS   Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Culicini; Culex; Culex.
OX   NCBI_TaxID=7176;
RN   [1] {ECO:0000313|EMBL:EDS26241.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHB {ECO:0000313|EMBL:EDS26241.1};
RG   The Broad Institute Genome Sequencing Platform;
RA   Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA   Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA   Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA   Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA   Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA   Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA   Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA   Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT   "Annotation of Culex pipiens quinquefasciatus.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:CPIJ006043-PA}
RP   IDENTIFICATION.
RC   STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ006043-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
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DR   EMBL; DS231918; EDS26241.1; -; Genomic_DNA.
DR   RefSeq; XP_001847457.1; XM_001847405.1.
DR   AlphaFoldDB; B0WFH3; -.
DR   STRING; 7176.B0WFH3; -.
DR   EnsemblMetazoa; CPIJ006043-RA; CPIJ006043-PA; CPIJ006043.
DR   GeneID; 6037559; -.
DR   KEGG; cqu:CpipJ_CPIJ006043; -.
DR   VEuPathDB; VectorBase:CPIJ006043; -.
DR   VEuPathDB; VectorBase:CQUJHB002401; -.
DR   eggNOG; KOG1158; Eukaryota.
DR   HOGENOM; CLU_001570_17_0_1; -.
DR   InParanoid; B0WFH3; -.
DR   OMA; DHYKVEI; -.
DR   OrthoDB; 276396at2759; -.
DR   Proteomes; UP000002320; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   CDD; cd06203; methionine_synthase_red; 1.
DR   Gene3D; 3.40.50.80; Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module; 1.
DR   Gene3D; 2.40.30.10; Translation factors; 1.
DR   InterPro; IPR003097; CysJ-like_FAD-binding.
DR   InterPro; IPR017927; FAD-bd_FR_type.
DR   InterPro; IPR001709; Flavoprot_Pyr_Nucl_cyt_Rdtase.
DR   InterPro; IPR039261; FNR_nucleotide-bd.
DR   InterPro; IPR023173; NADPH_Cyt_P450_Rdtase_alpha.
DR   InterPro; IPR001433; OxRdtase_FAD/NAD-bd.
DR   InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR   PANTHER; PTHR19384:SF84; METHIONINE SYNTHASE REDUCTASE; 1.
DR   PANTHER; PTHR19384; NITRIC OXIDE SYNTHASE-RELATED; 1.
DR   Pfam; PF00667; FAD_binding_1; 1.
DR   Pfam; PF00175; NAD_binding_1; 1.
DR   PRINTS; PR00371; FPNCR.
DR   SUPFAM; SSF52343; Ferredoxin reductase-like, C-terminal NADP-linked domain; 1.
DR   SUPFAM; SSF63380; Riboflavin synthase domain-like; 1.
DR   PROSITE; PS51384; FAD_FR; 1.
PE   4: Predicted;
KW   FAD {ECO:0000256|ARBA:ARBA00022827};
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002320}.
FT   DOMAIN          53..288
FT                   /note="FAD-binding FR-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51384"
SQ   SEQUENCE   446 AA;  50420 MW;  708827B1D39D7350 CRC64;
     MLDLADLVEK YGEILTIPPA PVKFIKLVDA ESDEEQPNNY HLQSSCIQPF CATRVFQYKI
     SNHKIIAQGE DIKTVYDVVL TTASEVDYRW TPGDTVGILT RNSDEDVDSL VDHLELQSIQ
     HKLYRVEVDP ATKKKGAKVP VYIPKLVPLR KLFAECLDLK SIPKKLFIRA LLDFTEDDAE
     KRLLSVLCSK DSSAFDDVVL KTGMSFLTLL QNVPRCKPPV SVLIEHLPRL MPRPYSIANA
     HGEGGKVRIL FSISEACPGL TTSFLRSCCD TNDPVFLYFR STTHFSYKED DLLKDIVMIG
     VGTGIAPYLG ILEHRRNSKE AGSLGKAWLF AGFRHEETSY LCRDELSRCL KDNILNDLSV
     AFSRDPNAHC RYVQDQLEAN KERLGRTLCD SDGKLYVCGD GKMMLPQVEE KIGKILADVL
     CISDEQVKAL IKEWKTKHKY IEDVWL
//