ID B0WFQ0_CULQU Unreviewed; 457 AA.
AC B0WFQ0;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE SubName: Full=T-cell specific transcription factor, tcf {ECO:0000313|EMBL:EDS26394.1, ECO:0000313|EnsemblMetazoa:CPIJ005215-PA};
GN Name=6037647 {ECO:0000313|EnsemblMetazoa:CPIJ005215-PA};
GN ORFNames=CpipJ_CPIJ005215 {ECO:0000313|EMBL:EDS26394.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS26394.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS26394.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ005215-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ005215-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the TCF/LEF family.
CC {ECO:0000256|ARBA:ARBA00006569}.
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DR EMBL; DS231920; EDS26394.1; -; Genomic_DNA.
DR RefSeq; XP_001847534.1; XM_001847482.1.
DR AlphaFoldDB; B0WFQ0; -.
DR STRING; 7176.B0WFQ0; -.
DR EnsemblMetazoa; CPIJ005215-RA; CPIJ005215-PA; CPIJ005215.
DR KEGG; cqu:CpipJ_CPIJ005215; -.
DR VEuPathDB; VectorBase:CPIJ005215; -.
DR VEuPathDB; VectorBase:CQUJHB015505; -.
DR eggNOG; KOG3248; Eukaryota.
DR HOGENOM; CLU_013229_2_2_1; -.
DR InParanoid; B0WFQ0; -.
DR OMA; HSHNVLN; -.
DR OrthoDB; 5351131at2759; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd21996; HMG-box_TCF7-like; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR027397; Catenin-bd_sf.
DR InterPro; IPR013558; CTNNB1-bd_N.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR024940; TCF/LEF.
DR PANTHER; PTHR10373:SF38; PROTEIN PANGOLIN, ISOFORM J; 1.
DR PANTHER; PTHR10373; TRANSCRIPTION FACTOR 7 FAMILY MEMBER; 1.
DR Pfam; PF08347; CTNNB1_binding; 1.
DR Pfam; PF00505; HMG_box; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00267}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT DOMAIN 329..397
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 329..397
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 64..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 258..326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 404..425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..42
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 289..325
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 457 AA; 49671 MW; 55BCB300CA598C64 CRC64;
MPNTNENSHS GSTGDDLGST DEVKVFKDEG DREDEKASSE NLLEEKFNLI DLTESAENLV
KNSRQDLSPP FSSAGGGGGG SGGSSAGKLN SPDHSPGFMG YLPPYQYSSG TASAIQGSIS
KMGLSQFFCN EDPLSNPPPA HCGIIPYQLD SKALGLSARQ SLYSFSTSQY PYPILSSNML
PVPPSWHTPS MYSTAPSSFR NSYPSSLQIY TTLASDLYSR YQQSSSLLNS VHPAHQVLSQ
VKQEVASHDA LSHNYSVRQA HHHHLQSHQS SSSKSTDLPQ ELTLNRGYGR PATGSSAGSS
SGGSAASSGG GGTKKKLTSA QQANLKPHIK KPLNAFMLYM KEMRAKVVAE CTLKESAAIN
QILGRKWHSL TREEQSVYYD KARQERQLHM EMYPGWTARD NYGYGSKKKR KAKKKDTLGG
DGSASRRKKI CIRTDEADNY DGTRMSDEFM GSYGTVV
//
