ID B0WJ26_CULQU Unreviewed; 978 AA.
AC B0WJ26;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 24-JAN-2024, entry version 98.
DE RecName: Full=Atrial natriuretic peptide-converting enzyme {ECO:0008006|Google:ProtNLM};
GN Name=6039031 {ECO:0000313|EnsemblMetazoa:CPIJ007155-PA};
GN ORFNames=CpipJ_CPIJ007155 {ECO:0000313|EMBL:EDS28905.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS28905.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS28905.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ007155-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ007155-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the peptidase S1 family. CLIP subfamily.
CC {ECO:0000256|ARBA:ARBA00024195}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR EMBL; DS231955; EDS28905.1; -; Genomic_DNA.
DR RefSeq; XP_001848710.1; XM_001848658.1.
DR AlphaFoldDB; B0WJ26; -.
DR STRING; 7176.B0WJ26; -.
DR EnsemblMetazoa; CPIJ007155-RA; CPIJ007155-PA; CPIJ007155.
DR KEGG; cqu:CpipJ_CPIJ007155; -.
DR VEuPathDB; VectorBase:CPIJ007155; -.
DR VEuPathDB; VectorBase:CQUJHB003789; -.
DR eggNOG; KOG3577; Eukaryota.
DR eggNOG; KOG3627; Eukaryota.
DR HOGENOM; CLU_006842_19_1_1; -.
DR InParanoid; B0WJ26; -.
DR OMA; WHVALFK; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd07066; CRD_FZ; 1.
DR CDD; cd00112; LDLa; 2.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR000082; SEA_dom.
DR InterPro; IPR036364; SEA_dom_sf.
DR InterPro; IPR001254; Trypsin_dom.
DR PANTHER; PTHR24258:SF146; -; 1.
DR PANTHER; PTHR24258; SERINE PROTEASE-RELATED; 1.
DR Pfam; PF01392; Fz; 1.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR Pfam; PF01390; SEA; 1.
DR Pfam; PF00089; Trypsin; 2.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00063; FRI; 1.
DR SMART; SM00192; LDLa; 2.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 1.
DR SUPFAM; SSF82671; SEA domain; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50068; LDLRA_2; 1.
DR PROSITE; PS50024; SEA; 1.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 137..162
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 168..289
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
FT DOMAIN 317..443
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 630..975
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT REGION 1..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 748..792
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..28
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..62
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..110
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 322..383
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 330..376
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 492..507
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 978 AA; 109366 MW; ED7C4C8EBAD14814 CRC64;
MKSSKYPESD DNDSLPPPPP PEDDPYFDDL SPPPGLNHLN HLDTLPQTTT IPAGTTATGM
SPEKSRKQHR SSSDAKHHHR NGGNGLHHKG SNGAGHHHHH HHHHHRHSKS SRADSVLSSD
SDIRFTRRKL GDNQKCGCAL IAGFLLILLF AGVIVYVGYT YLRPEPLPDR IFRARLRVVD
GDHWTPELAD QSTLRFQHKS RDYRERINLI MRRSDLREPY EGSEILALDG NEGEDLTLHF
AMYFDPYAEL VSAADLHSIM MEEITSDSPR FFRNLTIDPS SLIIKEVLGQ FDDIPGTSSS
PLGGKDDVVS EVVTTMRPPR KCEPLRLNYC RSVGYNMTTY PNFFGHNSVE EVEADLISFR
ELVDAECFRQ AFDFICRLLQ PPCEYRRIEE PTAGKVCRQY CQAFWAGCGD RLPERFRRFM
DCERFPESTG IQSCHSRPGC SGELQSNALS SRMCDGVADC PDLSDENTCT FCAYGAIYCG
RGRVCYARNA RCDGKIDCPD GADEKDCLSI SPQVTHLTFP PPIVPHRPRF YSEGYAVFSE
KGTTGKLCSV GMESNEYVRN TVAESLCKAL GFERVDFSEI RNDTEPNTSY VRVLDPRASE
ISFVRTTCQS KQSLYVSCGQ LECGVQSALP NGGNVGLSKM AAPGDWPWLV ALFRADTHVC
DGTLVSSDWV LTTESCFQGQ AKATWYAIFG AVRLTSNAPW TQRRRIIGMV KSPVEGSTAA
LVRLENPVIY SDFVRPICLP DIPLKETIDR SDNVTPTPHA EKFSKSRSKK RIKENRQYFE
TPGDDETASS DEYSDVTESS KFSVNEFTAE FADEGSQIPK AEAVGAVSGT RNPYPLPENS
PQTNNYISPS NYIGHSFTPP KAKQTVWTNC NTLGWSRQRD HLQRVQLKIS DMKPCENISI
ATVNSMCTEA AYHKQDCSEE EFAGSPVVCL LPAERKWALV GVASWRIACA PNGIERPRMY
DKITSNTQWL RETIAATV
//
