GenomeNet

Database: UniProt
Entry: B0WJU0_CULQU
LinkDB: B0WJU0_CULQU
Original site: B0WJU0_CULQU 
ID   B0WJU0_CULQU            Unreviewed;       857 AA.
AC   B0WJU0;
DT   08-APR-2008, integrated into UniProtKB/TrEMBL.
DT   08-APR-2008, sequence version 1.
DT   24-JAN-2024, entry version 98.
DE   RecName: Full=RBR-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012251};
DE            EC=2.3.2.31 {ECO:0000256|ARBA:ARBA00012251};
GN   Name=6039352 {ECO:0000313|EnsemblMetazoa:CPIJ007284-PA};
GN   ORFNames=CpipJ_CPIJ007284 {ECO:0000313|EMBL:EDS29458.1};
OS   Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Culicini; Culex; Culex.
OX   NCBI_TaxID=7176;
RN   [1] {ECO:0000313|EMBL:EDS29458.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHB {ECO:0000313|EMBL:EDS29458.1};
RG   The Broad Institute Genome Sequencing Platform;
RA   Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA   Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA   Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA   Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA   Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA   Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA   Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA   Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT   "Annotation of Culex pipiens quinquefasciatus.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:CPIJ007284-PA}
RP   IDENTIFICATION.
RC   STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ007284-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine +
CC         [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC         cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.;
CC         EC=2.3.2.31; Evidence={ECO:0000256|ARBA:ARBA00001798};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DS231964; EDS29458.1; -; Genomic_DNA.
DR   RefSeq; XP_001848975.1; XM_001848923.1.
DR   AlphaFoldDB; B0WJU0; -.
DR   STRING; 7176.B0WJU0; -.
DR   EnsemblMetazoa; CPIJ007284-RA; CPIJ007284-PA; CPIJ007284.
DR   KEGG; cqu:CpipJ_CPIJ007284; -.
DR   VEuPathDB; VectorBase:CPIJ007284; -.
DR   VEuPathDB; VectorBase:CQUJHB000970; -.
DR   eggNOG; KOG1815; Eukaryota.
DR   HOGENOM; CLU_016793_2_0_1; -.
DR   InParanoid; B0WJU0; -.
DR   OMA; ENYLMIQ; -.
DR   OrthoDB; 2943236at2759; -.
DR   Proteomes; UP000002320; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR   CDD; cd20338; BRcat_RBR_RNF19; 1.
DR   CDD; cd20355; Rcat_RBR_RNF19; 1.
DR   Gene3D; 1.20.120.1750; -; 1.
DR   Gene3D; 2.20.25.20; -; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR031127; E3_UB_ligase_RBR.
DR   InterPro; IPR002867; IBR_dom.
DR   InterPro; IPR044066; TRIAD_supradom.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR11685; RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING; 1.
DR   PANTHER; PTHR11685:SF427; RBR-TYPE E3 UBIQUITIN TRANSFERASE; 1.
DR   Pfam; PF01485; IBR; 2.
DR   SMART; SM00647; IBR; 2.
DR   SMART; SM00184; RING; 1.
DR   SUPFAM; SSF57850; RING/U-box; 3.
DR   PROSITE; PS51873; TRIAD; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00175}.
FT   TRANSMEM        362..395
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        415..446
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          133..352
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51873"
FT   DOMAIN          137..185
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
FT   REGION          25..133
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          276..297
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          663..707
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          741..857
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        71..123
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        685..707
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        753..772
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        782..799
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        832..857
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   857 AA;  90303 MW;  B2F1692B5720871E CRC64;
     MRRTSRNSFN FDFSLRRLLL QGARAARGSP PLGQRLCDVE KGGGSGGGGS GSGGGGPSGS
     KHHDKHGGSS SGSNKHNSDS TSQHSANSPG NLDRGTSTSK LTPNSHKSSS SLQSKSTAGS
     GSAAGATAGA GKSPEECPLC YDTVPVGQEF YALLNCKHYA CRSCLENYLR IEISESRTDI
     SCPQCPESMH PTDIQTLLKA SPAAITKYED FMVRRVLLAD PDSRWCPGPD CSYAVVATGC
     ASCPRIRCER PGCDVQFCYH CKAEWHPDQT CDAARASRQS PTRAPSGSIS QDSHHKDDIK
     PCPRCQVLIV KMDDGSCNHM VCAICGSEFC WLCMKEISDL HYLSPSGCTF WGKKPWSRKK
     KLLWQLGTLV GAPLGIALVA GIAVPAMIIG IPVWVGRKIH TRYKTAGKHK RNFAVLGGVT
     ASVIVSPVLA GLAVAIGVPI LLFYVYGVVP VSLCRAGCGE GTRFEFDEEE DNGSRNHDAT
     SVDAVSRIGA TSIGEVSLSV ASGSHLGVSS QHSNFGVVTN PSTRESTTAL AGSITGHRLE
     VQADISTSET ASAVTCVSEK SGNTLNDTAS TKALAGSILS YRAYQMASDS ACFSASEDGG
     SSERVRFDSN VCYVIDGGGV ASSMAATATG AGKEGGPSTA TGGKKDTCDI WYTVPLDQDT
     AADKASLGSG RSFRSSERSF RDDFDSTSLS SAHTNTGTAT TTSNSHHSHV AIAAATNPAV
     AAAAATTSGS SKHQRMNAFG TRIPKLGSGP HQHRTLSMDS TTGSYNIPEN VSLEQEEQEE
     QEQQQQQQQQ QQQSSPALSK VVGVAAEEEK EKVDNVAAPI VEPKSRRTHI LRNLFFAQSG
     SPGNDGHQQQ QGDSSKT
//
DBGET integrated database retrieval system