ID B0WJU0_CULQU Unreviewed; 857 AA.
AC B0WJU0;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 24-JAN-2024, entry version 98.
DE RecName: Full=RBR-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012251};
DE EC=2.3.2.31 {ECO:0000256|ARBA:ARBA00012251};
GN Name=6039352 {ECO:0000313|EnsemblMetazoa:CPIJ007284-PA};
GN ORFNames=CpipJ_CPIJ007284 {ECO:0000313|EMBL:EDS29458.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS29458.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS29458.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ007284-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ007284-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.;
CC EC=2.3.2.31; Evidence={ECO:0000256|ARBA:ARBA00001798};
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DR EMBL; DS231964; EDS29458.1; -; Genomic_DNA.
DR RefSeq; XP_001848975.1; XM_001848923.1.
DR AlphaFoldDB; B0WJU0; -.
DR STRING; 7176.B0WJU0; -.
DR EnsemblMetazoa; CPIJ007284-RA; CPIJ007284-PA; CPIJ007284.
DR KEGG; cqu:CpipJ_CPIJ007284; -.
DR VEuPathDB; VectorBase:CPIJ007284; -.
DR VEuPathDB; VectorBase:CQUJHB000970; -.
DR eggNOG; KOG1815; Eukaryota.
DR HOGENOM; CLU_016793_2_0_1; -.
DR InParanoid; B0WJU0; -.
DR OMA; ENYLMIQ; -.
DR OrthoDB; 2943236at2759; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR CDD; cd20338; BRcat_RBR_RNF19; 1.
DR CDD; cd20355; Rcat_RBR_RNF19; 1.
DR Gene3D; 1.20.120.1750; -; 1.
DR Gene3D; 2.20.25.20; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR031127; E3_UB_ligase_RBR.
DR InterPro; IPR002867; IBR_dom.
DR InterPro; IPR044066; TRIAD_supradom.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR11685; RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR11685:SF427; RBR-TYPE E3 UBIQUITIN TRANSFERASE; 1.
DR Pfam; PF01485; IBR; 2.
DR SMART; SM00647; IBR; 2.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 3.
DR PROSITE; PS51873; TRIAD; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT TRANSMEM 362..395
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 415..446
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 133..352
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS51873"
FT DOMAIN 137..185
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 25..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 276..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 663..707
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 741..857
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..123
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 685..707
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 753..772
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 782..799
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 832..857
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 857 AA; 90303 MW; B2F1692B5720871E CRC64;
MRRTSRNSFN FDFSLRRLLL QGARAARGSP PLGQRLCDVE KGGGSGGGGS GSGGGGPSGS
KHHDKHGGSS SGSNKHNSDS TSQHSANSPG NLDRGTSTSK LTPNSHKSSS SLQSKSTAGS
GSAAGATAGA GKSPEECPLC YDTVPVGQEF YALLNCKHYA CRSCLENYLR IEISESRTDI
SCPQCPESMH PTDIQTLLKA SPAAITKYED FMVRRVLLAD PDSRWCPGPD CSYAVVATGC
ASCPRIRCER PGCDVQFCYH CKAEWHPDQT CDAARASRQS PTRAPSGSIS QDSHHKDDIK
PCPRCQVLIV KMDDGSCNHM VCAICGSEFC WLCMKEISDL HYLSPSGCTF WGKKPWSRKK
KLLWQLGTLV GAPLGIALVA GIAVPAMIIG IPVWVGRKIH TRYKTAGKHK RNFAVLGGVT
ASVIVSPVLA GLAVAIGVPI LLFYVYGVVP VSLCRAGCGE GTRFEFDEEE DNGSRNHDAT
SVDAVSRIGA TSIGEVSLSV ASGSHLGVSS QHSNFGVVTN PSTRESTTAL AGSITGHRLE
VQADISTSET ASAVTCVSEK SGNTLNDTAS TKALAGSILS YRAYQMASDS ACFSASEDGG
SSERVRFDSN VCYVIDGGGV ASSMAATATG AGKEGGPSTA TGGKKDTCDI WYTVPLDQDT
AADKASLGSG RSFRSSERSF RDDFDSTSLS SAHTNTGTAT TTSNSHHSHV AIAAATNPAV
AAAAATTSGS SKHQRMNAFG TRIPKLGSGP HQHRTLSMDS TTGSYNIPEN VSLEQEEQEE
QEQQQQQQQQ QQQSSPALSK VVGVAAEEEK EKVDNVAAPI VEPKSRRTHI LRNLFFAQSG
SPGNDGHQQQ QGDSSKT
//