ID B0WK73_CULQU Unreviewed; 1052 AA.
AC B0WK73;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 24-JAN-2024, entry version 75.
DE RecName: Full=Gamma-tubulin complex component {ECO:0000256|RuleBase:RU363050};
GN Name=6039504 {ECO:0000313|EnsemblMetazoa:CPIJ006732-PA};
GN ORFNames=CpipJ_CPIJ006732 {ECO:0000313|EMBL:EDS29647.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS29647.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS29647.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ006732-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ006732-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center {ECO:0000256|RuleBase:RU363050}.
CC -!- SIMILARITY: Belongs to the TUBGCP family.
CC {ECO:0000256|ARBA:ARBA00010337, ECO:0000256|RuleBase:RU363050}.
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DR EMBL; DS231968; EDS29647.1; -; Genomic_DNA.
DR RefSeq; XP_001849107.1; XM_001849055.1.
DR AlphaFoldDB; B0WK73; -.
DR STRING; 7176.B0WK73; -.
DR EnsemblMetazoa; CPIJ006732-RA; CPIJ006732-PA; CPIJ006732.
DR KEGG; cqu:CpipJ_CPIJ006732; -.
DR VEuPathDB; VectorBase:CPIJ006732; -.
DR VEuPathDB; VectorBase:CQUJHB006405; -.
DR eggNOG; KOG4344; Eukaryota.
DR HOGENOM; CLU_011574_0_0_1; -.
DR InParanoid; B0WK73; -.
DR OMA; RTNQFEV; -.
DR OrthoDB; 3678492at2759; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR GO; GO:0000922; C:spindle pole; IEA:InterPro.
DR GO; GO:0043015; F:gamma-tubulin binding; IEA:InterPro.
DR GO; GO:0007020; P:microtubule nucleation; IEA:InterPro.
DR CDD; cd22572; GCP5_NTD; 1.
DR Gene3D; 1.20.120.1900; Gamma-tubulin complex, C-terminal domain; 1.
DR InterPro; IPR007259; GCP.
DR InterPro; IPR040457; GCP_C.
DR InterPro; IPR042241; GCP_C_sf.
DR InterPro; IPR041470; GCP_N.
DR PANTHER; PTHR19302; GAMMA TUBULIN COMPLEX PROTEIN; 1.
DR PANTHER; PTHR19302:SF33; GAMMA-TUBULIN COMPLEX COMPONENT 5; 1.
DR Pfam; PF04130; GCP_C_terminal; 1.
DR Pfam; PF17681; GCP_N_terminal; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU363050};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW ECO:0000256|RuleBase:RU363050};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701, ECO:0000256|RuleBase:RU363050};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320}.
FT DOMAIN 291..511
FT /note="Gamma tubulin complex component protein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF17681"
FT DOMAIN 722..1006
FT /note="Gamma tubulin complex component C-terminal"
FT /evidence="ECO:0000259|Pfam:PF04130"
FT REGION 161..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..193
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1052 AA; 120747 MW; 3E06134A56DE4FB4 CRC64;
MSQAYEEREG YIQLLIPELI QQLTGFDETE ENFTLCHQFA VATIRNHRFL SVNSHEIRRR
ADGLMQNLRI SNLERVADQF RGLFEAFVVE PACADHYVHD IQWSVLLFLM TVAHNPVGAL
KERVRRGSPV AMLEAGSGSE VDAVEDDERR ELVEELREDD IEVGGGREVE DDSELSEWTD
SEGEEEGEGE QVVPEVVEES KVEAKEVVIY TRVESPKRDL GYESFDASGS EDWLKENVQS
NWWQNPKAKA EVNSSHEGAS FCDYWSQTIL KASHSFIKPD PVSTVSEYCL IREILWMFTN
PANCKFFRID DDQVWINPNV SLSSTTERGL HTFLLNFTEH MTIVYRLRNF CQKVANTSSK
PIPAPYSFEC YASGVRDFLK NLETTVVDLE KQAIAQQPDR IFTIITLFHD LEPQFQLLKN
LNDIHRYSVL DWTKFPAHIA VAHLLSGLFR SVKLSGNLAK SNLAFSLLLS TLKGYMNIID
MWWTEGRLDD WREEFLVEKT YSEADGTSVT GYRARLFSKC KKRSFYVSAA ISEVIETDAI
IQLLMHHSLE AGYTLNILSC LDRISDLRSG CAWEEGMLYV GFLERSWTCS TGPDVEEKVK
RCAFEARRRE TADTVSASKL QNLRNQIREI CDDELLMMAL DSSLQLACAD DDEEECQLPS
APSPNCLTNA HSLYTRLNSI SGQLMLPLEH VLFGAIKNLM ETKRQAANHF VTTIYKEEFL
VLHHLKNVRK VLLLEASDLM YYFYNDLFRR IEAGESWANP YLLTIQLNDI LASRFNDMTS
LFTIEIVPKH KAEPTTVLDA IDKLRILYDP GNDLSNMINE EAMASYNCLF RFLLKVKWAL
CTLESLRFPE CYKRRPPYEE PCVLDLNLKR LSMLKFWMIF SVQCIHSHLM THVLQSLGMQ
LDERLEAADN LNEMIAVHRS YIGTIYDHSF QTDDSKPFRE GVIRLLNLVH IVRDEWNSNV
LYVEMDARGD IEDNSMIGDF IANAQVGMLE TTYCKCHQQL AELLNREVYA KRKMHPQATS
HVPKSSSSNP PKRITLVLTN AIQTTNQPIR NC
//
