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Database: UniProt
Entry: B0WK88_CULQU
LinkDB: B0WK88_CULQU
Original site: B0WK88_CULQU 
ID   B0WK88_CULQU            Unreviewed;       913 AA.
AC   B0WK88;
DT   08-APR-2008, integrated into UniProtKB/TrEMBL.
DT   08-APR-2008, sequence version 1.
DT   30-AUG-2017, entry version 63.
DE   SubName: Full=Transient receptor potential cation channel protein painless {ECO:0000313|EMBL:EDS29662.1, ECO:0000313|VectorBase:CPIJ006747-PA};
GN   Name=6039520 {ECO:0000313|VectorBase:CPIJ006747-PA};
GN   ORFNames=CpipJ_CPIJ006747 {ECO:0000313|EMBL:EDS29662.1};
OS   Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Culicinae; Culicini; Culex; Culex.
OX   NCBI_TaxID=7176 {ECO:0000313|Proteomes:UP000002320};
RN   [1] {ECO:0000313|Proteomes:UP000002320}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHB {ECO:0000313|Proteomes:UP000002320};
RG   The Broad Institute Genome Sequencing Platform;
RA   Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.D.,
RA   Hannick L.I., Megy K., O'Leary S.B., Pearson M., Haas B.J.,
RA   Mauceli E., Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L.,
RA   Amedeo P., Antoine C.H., Arensburger P., Bidwell S.L., Crawford M.,
RA   Camaro F., Devon K., Engels R., Hammond M., Howarth C., Koehrsen M.,
RA   Lawson D., Montgomery P., Nene V., Nusbaum C., Puiu D.,
RA   Romero-Severson J., Severson D.W., Shumway M., Sisk P., Stolte C.,
RA   Zeng Q., Eisenstadt E., Fraser-Liggett C.M., Strausberg R.,
RA   Galagan J., Birren B., Collins F.H.;
RT   "Annotation of Culex pipiens quinquefasciatus.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EDS29662.1, ECO:0000313|VectorBase:CPIJ006747-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHB {ECO:0000313|EMBL:EDS29662.1,
RC   ECO:0000313|VectorBase:CPIJ006747-PA};
RG   The Broad Institute Genome Sequencing Platform;
RA   Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA   Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA   Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA   Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA   Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA   Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA   Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA   Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT   "Annotation of Culex pipiens quinquefasciatus.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|VectorBase:CPIJ006747-PA}
RP   IDENTIFICATION.
RC   STRAIN=JHB {ECO:0000313|VectorBase:CPIJ006747-PA};
RG   VectorBase;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
CC       {ECO:0000256|SAAS:SAAS00788929}.
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DR   EMBL; DS231968; EDS29662.1; -; Genomic_DNA.
DR   RefSeq; XP_001849122.1; XM_001849070.1.
DR   ProteinModelPortal; B0WK88; -.
DR   STRING; 7176.CPIJ006747-PA; -.
DR   EnsemblMetazoa; CPIJ006747-RA; CPIJ006747-PA; CPIJ006747.
DR   GeneID; 6039520; -.
DR   KEGG; cqu:CpipJ_CPIJ006747; -.
DR   VectorBase; CPIJ006747-RA; CPIJ006747-PA; CPIJ006747.
DR   eggNOG; KOG0510; Eukaryota.
DR   eggNOG; COG0666; LUCA.
DR   HOGENOM; HOG000045873; -.
DR   InParanoid; B0WK88; -.
DR   OMA; KELPICE; -.
DR   OrthoDB; EOG091G025V; -.
DR   PhylomeDB; B0WK88; -.
DR   Proteomes; UP000002320; Partially assembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005216; F:ion channel activity; IEA:InterPro.
DR   CDD; cd00204; ANK; 2.
DR   Gene3D; 1.25.40.20; -; 2.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   SMART; SM00248; ANK; 5.
DR   SUPFAM; SSF48403; SSF48403; 3.
DR   PROSITE; PS50297; ANK_REP_REGION; 2.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|SAAS:SAAS00844120};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002320};
KW   Ion channel {ECO:0000256|SAAS:SAAS00816195};
KW   Ion transport {ECO:0000256|SAAS:SAAS00816776};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:EDS29662.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|SAAS:SAAS00816535}.
FT   TRANSMEM    500    520       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    594    617       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    637    655       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    713    733       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       15    163       ANK_REP_REGION. {ECO:0000259|PROSITE:
FT                                PS50297}.
FT   DOMAIN      356    402       ANK_REP_REGION. {ECO:0000259|PROSITE:
FT                                PS50297}.
SQ   SEQUENCE   913 AA;  102586 MW;  5FA88260325DE128 CRC64;
     MNNNTANFPL LCIADPQHAL AASLAERNLK HFQLALNLGA DPNRRDSSSS NQSVFEHACQ
     SAGCSSFIVE CLKHHADVQQ PNADGRYPIH HAAASLDVEN IRALLDHSET IGLDVQYQQR
     TALHLLFESI NDGNWRAVFG CVQLLIDRGA NVNVPNEDNR SALGVFVRDS RRKVGTELWR
     EEVVRYCLKA GWVDVDSFRR GELRKQIGEL FPGVSIPVYV MEANLNALLA AVKSRNEGKF
     DLVLAQYRDK VDEATRRGDF GVLLEETVLT GRVSFVEKVL SEDFVFEGDS GVTRLLETCC
     NRGFPDLLKF LLSKCGQKED QVRQINASPL LSQTIREMNI QKDNRKCPFF KCFNILLEDG
     RVEIDKVDEK GFSALHYAVK YKVDAAVELL LQCSAYIGTL NMFKELPICE MDPDALEGYL
     DSCITTNEKR PGDDDYEISI DFSCLVPPTY KKNFSEKKQP PPIDEMLPIV YMSNSNDLKH
     LLKHPVISSY VLIKWLRLSI YFYVNLLVCT VFFASFTGYV VGCYGQDNVT RWLKETLRCV
     SLLGATYMLL RELGQMILHS KTYFRSLENW MELSLIALSY TVLLKEFQSE TRQIISAIVI
     LLSAVEFTLL VGTLPVLSIS THMVMLKTVS KNFLKSLVLY SIILISFAFC FYTLFNVNNA
     RSAKDGSGGD AEGESDDEKF NGFSGIQMAL LKTFVMLTGE FEAANIKFQN NGLSYIIFLL
     FLFFVAIVIF NLMNGLAVSD TAAIKAEAEL IGLSQKVDVI SKYENAIKAK STGVFTNLIF
     SIFRSNFLHL FPEYLPCSQV IVKPNQSNAI YIPKPLKPSE TESVIDVETQ SHIELMAPGS
     RGQEQFKLTI GCCILPSFSR MDGKIMKYAK EIIHTKSRKG ATPAGMVPLE QRMIQLERRL
     DLILQKLNIA SAS
//
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