ID B0WM18_CULQU Unreviewed; 4655 AA.
AC B0WM18;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 104.
DE SubName: Full=Dynein heavy chain {ECO:0000313|EMBL:EDS30832.1, ECO:0000313|EnsemblMetazoa:CPIJ007950-PA};
GN Name=6040349 {ECO:0000313|EnsemblMetazoa:CPIJ007950-PA};
GN ORFNames=CpipJ_CPIJ007950 {ECO:0000313|EMBL:EDS30832.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS30832.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS30832.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ007950-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ007950-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; DS231993; EDS30832.1; -; Genomic_DNA.
DR RefSeq; XP_001849752.1; XM_001849700.1.
DR STRING; 7176.B0WM18; -.
DR EnsemblMetazoa; CPIJ007950-RA; CPIJ007950-PA; CPIJ007950.
DR GeneID; 6040349; -.
DR KEGG; cqu:CpipJ_CPIJ007950; -.
DR VEuPathDB; VectorBase:CPIJ007950; -.
DR VEuPathDB; VectorBase:CQUJHB015696; -.
DR eggNOG; KOG3595; Eukaryota.
DR HOGENOM; CLU_000038_7_0_1; -.
DR InParanoid; B0WM18; -.
DR OMA; NERQMTR; -.
DR OrthoDB; 312195at2759; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 2.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 2.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 1.20.920.60; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46532:SF4; DYNEIN HEAVY CHAIN 8, AXONEMAL-LIKE PROTEIN; 1.
DR PANTHER; PTHR46532; MALE FERTILITY FACTOR KL5; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320}.
FT DOMAIN 1900..2051
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2214..2365
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2583..2733
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2925..3091
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 546..573
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1967..1994
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3204..3273
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3399..3468
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4655 AA; 531742 MW; AD9D87F14AF5243E CRC64;
MGDSLEATVG SSMGSDPPPS VVVDAESVAI MDYDGFTNYI RKAVTILLPE EDVVPVPLNA
ALDEPDNQEC IRKFLADPQT QALYIQRSCF KDDENEETEK EEKYTEYYIS NDVHFTNQRM
ASLVCIKRGA VIEADKSIHS QLRLINFSEG SPYETLHSFI SKTLAPYFKS YVKESGRADR
DGDKMAPSVE KKLAELEMGL LHLQQNIDIP EVTLNINSTV IQVVKKCADE GRKAKITDFG
DRVEDSTFLN TLQNGVNRWI KEIQKVTKLD RDPSSGTALQ EISFWLNLER ALHRIQEKRE
SPEVALTLNI LKHGKRFHAT VSFDTDTGLK QTLAMVADYN PLMKDFPIND LLSATELDKI
RQAVQCIFNH LRKIRSTKYP IQRCLRLIEA ISRDLSQQLL KVLGTRRLMH IPFDEFERVM
NQCFEVFSCW DDEYDKLQGI LRDIVKKKRD EHIKMVWRIA PAHKKLQQRM EHMRKFRRQH
EQLRTVIVRV LRPARQPAGS SDAGNGTDPK QPYSLDSADA NAIEEVNLAY ENVKEIECLD
ISKEGSEAWD AAIKRYEERI DRVETRITAH LRDQLGTAKN ANEMFRIFSR FNALFVRPHI
RGAIREYQTQ LIQRVKDDIE ALHEKFKVQY PQSKDCRLSV VRDLPPVAGS IIWARQIDNQ
LTMYLKRVED VLGKGWESHI DGQKLKADGD SFRAKLSTAE VFQEWARKVQ ERNTGITGRI
FLIESTRSRT GRGNTLKLRV NFLPEIITLY KEVRNLKSLG FRVPLAIVNK AHQANQLYPF
AISLIESVRT YERTLEKIED RASIIPLVAG LRKEVLALVS EGIALVWESY KLDPYVQRLS
ENVTSFQEKV EDLLVVEEQL DVDVRSLETC PYSAATFADI LSKIQHAVDD LSLKQYSNLH
VWVARLDEEV EKKLAARLQA GIQAWTDALT GNKKEVDLSM DTDAPAQPTI KPGGDPQIQR
AIHEIRITNQ QMYLYPSIEE ARFQIMQQLF AWEAIVTSQT RLQSSRYQVG LDKPVSQTYR
NLLTKLPGGS DPLEGSYGAI ENQISEVRNY VDEWLRYQSL WDLQADTLYG RLGEDINLWI
KCLNDIKKSR TTFDTSDTRR AYGPIVIDYA KVQAKVTLKY DSWHKEALSK FGQLLGNEMS
TFHTKVSKSR SDLEQQSIEA ASTSDAVCFI TYVQSLKKEM LVWDKQVEVY REAQRILERQ
RFQFPNNWLH VDNIEGEWSA FNEIMKRKDS AIQTQVASLQ AKIVAEDKAV ESRTVDFLND
WEKNKPTGGR TRPDDALQQL HIFETKFSRL KEERDNVAKA KEALELQESA IPNNSTERMS
VVLEELQDLR GVWSELSKIW TQIDETREKP WLSVQPRKLR QSLEAMMNQL KELPARLRMY
ESYEYVKKLI QSYIKVNMMI VELKSDALKE RHWKQLTKQL RVSWVLSDLT LGQVWDVNLL
KNESIVKDII LVAQGEMALE EFLKQVRESW QNYELDLINY QNKCRIIRGW DDLFNKVKEH
INSVAAMKLS PYYKVFEEEA LTWEEKLNRI NSLFDVWIDV QRRWVYLEGI FSGSADIKTL
LPVETSRFQS ISSEFLGLMK KVAKSPKVMD VLNIPAVQRS LERLADLLGK IQKALGEYLE
RERTSFPRFY FVGDEDLLEI IGNSKNVARL QKHFKKMFAG VASILLNEDN TVILGIASRE
GEEVKFIKPV STIDHPKINE WLTLVEKEMR FTLASYLAQA VQDIKQFKDE IDPQKYMEWC
DKYQAQIVVL AAQILWSEDV EAALQQATDS PSNKSPLNRV LSTVEATLNV LADSVLQEQP
ALRRKKLEHL INEFVHKRTV TRRLIAHGVS NPKSFHWLCE MRFYFDPRQT EVLQQLTIHM
ANARFYYGFE YLGVQDRLVQ TPLTDRCYLT MTQALEARLG GSPFGPAGTG KTESVKALGN
QLGRFVLVFN CDETFDFQAM GRIFVGLCQV GAWGCFDEFN RLEERMLSAV SQQIQTIQEA
LKSLQDSLKD AQSITVELVG KQVRVSTDMA IFITMNPGYA GRSNLPDNLK KLFRSLAMTT
PDRQLIAEVM LFSQGFRTAE KLACKIVPFF KLCDEQLSNQ SHYDFGLRAL KSVLVSAGNV
KRDRIMRIKE LMKQRGEENI DEASIAENLP EQEILIQSVC ETMVPKLVAE DIPLLFSLLS
DVFPNVGYTR AEMKGLKDEI RKVCAEEFLV CGEGEEQGGA WMEKVLQLYQ ISNLNHGLMM
VGPSGSGKST AWRVLLKSLE RFEGTEGVAH VIDPKAISKE ALYGVLDPNT REWTDGLFTH
ILRKIIDNVR GEINKRQWII FDGDVDPEWV ENLNSVLDDN KLLTLPNGER LSLPPNVRIM
FEVQDLKYAT LATVSRCGMV WFSEDVLSTE MIFENYMARI KNIPLEDGEE ESFTTSKASD
KEDELTPALQ TQREIASLLQ PYFTSDGLVV RCLEYAMGQE HIMDFTRLRA LSSLFSMLNQ
GARNVLNFNQ QHPDFPVPPE QLEQYIPKLL IYSLLWSFAG DAKLKVRSDL GDFLRSVTTV
TLPAQSGSPI IDYEVNIQGD WVPWSNKVPV IEVETHKVAA PDVVVPTLDT VRHESLLYTW
LAEHKPLVLC GPPGSGKTMT LFSALRALPD MEVVGLNFSS ATTPELLLKT FDHYCEYRKT
PNGVVLAPVQ LGKWLVLFCD EINLPDMDSY GTQRVISFLR QLVEHKGFYR AGDQSWVSLE
RIQFVGACNP PTDPGRKPLS HRFLRHVPII YVDYPGETSL KQIYGTFSRA MLRLMPSLRG
YAEPLTNAMV EFYLSSQDRF TQDMQPHYVY SPREMTRWVR GICEAIRPLD NLAVEGLVRL
WAHEALRLFQ DRLVEESERR WTNENIDLVA MKHFPSVDRE KALERPILYS NWLSKDYMPV
NRAELRDYVK ARLKVFYEEE LDVPLVLFDE VLEHVLRIDR IFRQPQGHLL LIGVSGAGKT
TLSRFVAWMN GLSIFQIKVH NKYTSEDFDE DLRCVLRRSG CKDEKIAFIL DESNVLDSGF
LERMNTLLAN GEVPGLFEGD EYTTLMTQCK EGAQREGLML DSSDELYKWF TQQVMRNLHV
VFTMNPSTDG LKDRAATSPA LFNRCVLNWF GDWSDSALFQ VGKEFTTRVD LDKPTWSAPD
FFPAACPLIN NTPSHRDAVI NGCVYVHQTL HKANGRLAKR GGRTMAITPR HYLDFIHHFV
KLYSEKRSDL EEQQLHLNVG LNKIAETVEQ VEEMQKSLAV KSQELHSKNE AANAKLKQMF
KDQQEAEKKK VQSQEIQQQL AEQTIKIEEK RKDVMADLAQ VEPAVIDAQA AVKSIKKQHL
VEVRSMANPP AVVKLALESI CLLLGENASD WKSIRAVIMR ENFINSIVSN FSTEDITDDV
REKMKSRYLS NPDYNFEKVN RASMACGPMV KWAIAQVEYA DMLKRVEPLR DELDSLERRA
DTNIKHGQEV KELITQLEQS IASYKEEYAQ LISQAQAIKT DLENVQAKVD RSIALLKSLV
IERERWEATS ETFRSQMSTI IGDVLLSAAF IAYGGYFDQH YRSNLFSTWC QHLQAANIQF
RADIARTEYL SNPDERLRWQ ANALPTDDLC TENAIMLKRF NRYPLIIDPS GQATEFIMNE
FKDKKITKTS FLDDSFRKNL ESALRFGNPL LVQDVENYDP ILNPVLNREL RRTGGRVLIT
LGDQDIDLSP SFVIFLSTRD PTVEFPPDIC SRVTFVNFTV TRSSLQSQCL NQVLKAERPD
IDEKRSDLLK LQGEFHLRLR QLEKSLLQAL NDAKGKILDD DSVITTLETL KKEAADIGQK
VEETDKVIGE IETVSQQYLS LSQACSNIYF TMDSLNQVHF LYQYSLKMFL DIFSTVLHNN
PKLDGKTDHT ARLSIITSDL YTVCYDRVAR GMLHADRLTF AILLCRIHLK GTNEANLDQE
FSFFLRNKEG LVSSAHHVDG VSAEQLESVT RLANRLPIFR KLLDKIQSMP ELSAWLQQGS
PEQNVPQLWD ESKALSPVSS SMHQLLLIQA FRPDRVIAAA HLFVSTVLGE HFMPNAEKEL
DFTACVEKEI ASNTPALLCS VTGYDASSRV DDLAAELNKQ ISSIAIGSAE GFNQAERAIN
MACKTGRWVL LKNVHLAPQW LVQLEKKLHS LQPHSGFRLF LTMEINPKVP VNLLRAGRIF
VYEPPPGIRA NLLRTFSTVP AARMMKPPSE RARLYFLLSW FHAIVQERLR YVPLGWAKKY
EFNESDLRVA CDTLDTWIDA TAMGRTNLPP EKVPWDALVT LLSQSIYGGK IDNDFDQRLL
SSFLSKLFTA HSFEAEFALV ANVDGVAGGP NGQRHITMPD GTRRDHFLKW IEALADRQTP
SWLGLPNNAE KVLLTTRGTD LISKLLKMQQ LEDDDELAYS NDESLDAVQT RQEDGRPSWM
KTLHNSALTW LELLPKQLAT LRRTVENIKD PLYRYFEREV SSGAKLLQTV VSDLQDVVFI
CQGEKKQTNY HRTMLSELVR GILPAGWRRY TVPVGCTVIQ WVTDFSQRVQ QLQKVSTLVS
QAGAKELQSF PVWLGGLFNP EAYITATRQC VAQANSWSLE ELTLNVTITE NGSDGFDNLK
DSSFGISGLK LQGAQCKNNQ LLLTSAIMTE LPLTLLKWTR IDAEGARPTK LTLPVYLNST
RTELLFTVDM TVAPGQDPHS FYERGVAVLS STALN
//
